Assessment of the dalargin effect on the level of vitamin D and melatonin in blood serum in patients with malignant bone tumors and polymorbidity DOI Creative Commons
O.V. Drobotun,

N. Kolotilov,

V.F. Konovalenko

et al.

PAIN JOINTS SPINE, Journal Year: 2024, Volume and Issue: 14(1), P. 36 - 41

Published: April 30, 2024

Background. Involved in many cascades of biological regulatory reactions, calcium, vitamin D and melatonin create a single metabolic pattern, maintaining the dynamic balance bone tissue homeostasis. Nevertheless, these molecules, as structural functional elements tissue, play crucial role various cellular processes associated with oncogenesis tumor progression. Synthetic peptide dalargin has wound healing, reparative, anti-inflammatory, antioxidant, immunomodulatory, anticarcinogenic, antitumor, antimetastatic effects. The purpose study was to investigate synthetic neuropeptide influence on dynamics blood serum le­vels part treatment algorithm patients malignant tumors lower extremities pelvis polymorbidity endoprosthetics. Materials methods. inclu­ded control (first) group main (second) clinical observation lesions. content measured by enzyme immunoassay using reagent kits (No. RE54021) from IBL-Hamburg GmbH (Germany). Serum levels 25-hydroxycalciferol (25(OH)D) were determined immunochemiluminescent method an ARCHITECT 25-OH Vitamin Controls automatic analyzer. Results. In who received dalargin, more pronounced positive established normalization 25(ОН)D levels, there no exacerbation concomitant diseases. contrast data did not receive where it used, relapses or metastases du­ring 14 months. A comparison 6–7 months 12–14 after shows tendency recovery indicators only additionally treated (p < 0.01). Conclusions. showed possibility increase effectiveness primary burden influencing serum.

Language: Английский

Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism DOI
Yueqi Chen, Chuan Yang,

Zihan Deng

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(3)

Published: April 1, 2024

Abstract Osteoporosis (OP) is a severe global health issue that has significant implications for productivity and human lifespan. Gut microbiota dysbiosis been demonstrated to be closely associated with OP progression. Melatonin (MLT) an important endogenous hormone modulates bone metabolism, maintains homeostasis, improves Multiple studies indicated MLT participates in the regulation of intestinal gut barrier function. However, promising effects microbiota‐derived remain unclear. Here, we found resulted tryptophan disorder decreased production MLT, while administration could mitigate OP‐related clinical symptoms reverse dysbiosis, including diversity microbiota, relative abundance many probiotics such as Allobaculum Parasutterella , metabolic function flora amino acid nucleotide energy metabolism. Notably, significantly increased short‐chain fatty acids trimethylamine N‐oxide‐related metabolites. Importantly, modulate dynamic balance M1/M2 macrophages, reduce serum levels pro‐inflammatory cytokines, restore gut‐barrier Taken together, our results highlighted roles microbially derived progression via “gut‐bone” axis SCFA which may provide novel insight into development drug treating OP.

Language: Английский

Citations

10
Non-diabetic elderly populations: the MHR as a protective factor against bone abnormalities DOI Creative Commons
Xiang Li,

Manli Yan,

Jiali Ji

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Objectives In China, osteoporosis has become a major health concern among elderly population, imposing significant burden on the country’s social and economic systems. The monocyte to high-density lipoprotein ratio (MHR) been currently recommended as novel marker of inflammation oxidative stress associated with in type 2 diabetes mellitus (T2DM). However, its reliability non-diabetic populations remains unclear. present study was evaluate association between MHR population. Methods clinical data 240 subjects (115 group 125 normal bone group) were retrospectively analyzed all statistical analyses performed by using SPSS 26.0. Results Differences age, neutrophils, lymphocytes, monocytes, MHR, uric acid, creatinine, triglycerides,and cholesterol found be statistically two groups. A binary logistic regression model conducted including UA Cr variables. results showed that age an independent risk factor protective for abnormality ROC analysis area under curve predictive effect their combined test 0.623, 0.728 0.761, respectively; correlation positively correlated lumbar hip BMD, negatively femoral neck ratio, intertrochanteric stem showing differences (P&lt;0.05). Conclusions For population: is against abnormalities significantly higher than abnormal group.

Language: Английский

Citations

2
Melatonin Regulates Osteoblast Differentiation through the m6A Reader hnRNPA2B1 under Simulated Microgravity DOI Creative Commons
Quan Sun, Liqun Xu,

Zebing Hu

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 9624 - 9638

Published: Sept. 1, 2024

Recent studies have confirmed that melatonin and N6-methyladenosine (m6A) modification can influence bone cell differentiation formation. Melatonin also regulate a variety of biological processes through m6A modification. Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) serves as reader In this study, we used the hindlimb unloading model an animal loss induced by simulated microgravity 2D clinorotation to simulate environment for cells on ground. We found hnRNPA2B1 was downregulated both in vitro vivo during microgravity. Further investigations showed could promote osteoblast overexpression attenuated suppression discovered expression under Moreover, promotion partially dependent hnRNPA2B1. Therefore, research revealed, first time, role melatonin/hnRNPA2B1 axis Targeting may be potential protective strategy against microgravity-induced osteoporosis.

Language: Английский

Citations

2
Mitochondria in skeletal system-related diseases DOI Open Access

Liang Pei,

Zizhen Yao, Liang Dong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117505 - 117505

Published: Nov. 4, 2024

Language: Английский

Citations

1
Assessment of the dalargin effect on the level of vitamin D and melatonin in blood serum in patients with malignant bone tumors and polymorbidity DOI Creative Commons
O.V. Drobotun,

N. Kolotilov,

V.F. Konovalenko

et al.

PAIN JOINTS SPINE, Journal Year: 2024, Volume and Issue: 14(1), P. 36 - 41

Published: April 30, 2024

Background. Involved in many cascades of biological regulatory reactions, calcium, vitamin D and melatonin create a single metabolic pattern, maintaining the dynamic balance bone tissue homeostasis. Nevertheless, these molecules, as structural functional elements tissue, play crucial role various cellular processes associated with oncogenesis tumor progression. Synthetic peptide dalargin has wound healing, reparative, anti-inflammatory, antioxidant, immunomodulatory, anticarcinogenic, antitumor, antimetastatic effects. The purpose study was to investigate synthetic neuropeptide influence on dynamics blood serum le­vels part treatment algorithm patients malignant tumors lower extremities pelvis polymorbidity endoprosthetics. Materials methods. inclu­ded control (first) group main (second) clinical observation lesions. content measured by enzyme immunoassay using reagent kits (No. RE54021) from IBL-Hamburg GmbH (Germany). Serum levels 25-hydroxycalciferol (25(OH)D) were determined immunochemiluminescent method an ARCHITECT 25-OH Vitamin Controls automatic analyzer. Results. In who received dalargin, more pronounced positive established normalization 25(ОН)D levels, there no exacerbation concomitant diseases. contrast data did not receive where it used, relapses or metastases du­ring 14 months. A comparison 6–7 months 12–14 after shows tendency recovery indicators only additionally treated (p < 0.01). Conclusions. showed possibility increase effectiveness primary burden influencing serum.

Language: Английский

Citations

0