Therapeutic role of melatonin on acrylamide-induced neurotoxicity via reducing ER stress, inflammation, and apoptosis in a rat model

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 11, 2025

This study examined the antioxidant, anti-inflammatory, and neuroprotective effects of melatonin (MEL) against acrylamide (ACR)-induced neurotoxicity in Sprague-Dawley rats. The experimental groups included control, ACR, MEL10+ACR, MEL20+ACR, MEL20. MEL at doses 10 20 mg/kg, ACR 50 were administered intraperitoneally for 14 days. On 15th day, locomotor activity was assessed, brain tissues analyzed biochemically, molecularly, histopathologically. exposure decreased activity, increased malondialdehyde (MDA) reduced glutathione (GSH) levels, indicating oxidative stress, antioxidant enzyme activities (SOD, GPx, CAT). High-dose (MEL20+ACR) effectively lipid peroxidation restored activities. treatment also suppressed proinflammatory cytokines (TNF-α, IL-1β, IL-6) neuronal nitric oxide synthase (nNOS), demonstrating anti-inflammatory effects. Furthermore, mitigated ACR-induced by reducing acetylcholinesterase (AChE) monoamine oxidase (MAO) levels. ER stress markers (GRP78, ATF4, ATF6, sXBP1, CHOP) apoptotic (Bax, Caspase-3) elevated following but MEL. Additionally, increases 8-hydroxy-2-deoxyguanosine (8-OHdG) glial fibrillary acidic protein (GFAP), DNA damage astrocyte activation, respectively. These findings underscore potential to counteract through its comprehensive actions.

Language: Английский

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Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 398, P. 111104 - 111104

Published: June 19, 2024

Language: Английский

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Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113935 - 113935

Published: Jan. 5, 2025

Language: Английский

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LINC00626 drives tamoxifen resistance in breast cancer cells by interaction with UPF1

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 23, 2025

Although tamoxifen is commonly utilized as adjuvant therapy for Estrogen Receptor alpha (ERα)-positive breast cancer patients, approximately 30–50% of individuals treated with experience relapse. Therefore, it essential to investigate additional factors besides ERα that influence the estrogen response. In this study, cross-analysis databases were performed, and results revealed a significant association between LINC00626 signaling well increased expression levels gene in tamoxifen-resistant cells. novel ERα-regulated long non-coding RNA (lncRNA) has not yet been examined its potential contribution endocrine resistance. This study upregulation was associated poor overall survival patients. Additionally, found transcriptionally regulate expression, thereby promoting progression enhancing resistance cells via regulation UPF1 expression. Depletion restored sensitivity by activating PERK-ATF4-CHOP pathway UPF1. These findings support role therapeutic target combating

Language: Английский

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The structural and functional dynamics of BiP and Grp94: opportunities for therapeutic discovery

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Endoplasmic reticulum stress in the pathogenesis of chemotherapy‐induced mucositis: Physiological mechanisms and therapeutic implications

Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(8)

Published: June 14, 2024

Chemotherapy is a common and effective treatment for cancer, but these drugs are also associated with significant side effects affecting patients' well-being. One such debilitating effect mucositis, characterized by inflammation, ulcerations, altered physiological functions of the gastrointestinal (GI) tract's mucosal lining. Understanding mechanisms chemotherapy-induced intestinal mucositis (CIM) crucial developing preventive measures supportive care. Chemotherapeutics not only target cancer cells rapidly dividing in GI tract. These disrupt endoplasmic reticulum (ER) homeostasis, leading to ER-stress activation unfolded protein response (UPR) various epithelial cell types. The UPR triggers signaling pathways that exacerbate tissue inflammation damage, influence differentiation fate cells, compromise integrity barrier. factors contribute significantly development progression. In this review, we aim give an in-depth overview role its impact on function. This will provide valuable insights into underlying highlighting potential therapeutic interventions could improve treatment-outcomes quality life patients.

Language: Английский

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Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 212, P. 115386 - 115386

Published: July 4, 2024

Language: Английский

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Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519

Published: Sept. 1, 2024

Language: Английский

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Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

ABSTRACT The unfolded protein response (UPR) is a cell-autonomous stress aimed at restoring homeostasis due to the accumulation of misfolded proteins in endoplasmic reticulum (ER). Viruses often hijack host cell machinery, leading an ER. UPR immediate infected this stress, aiming restore normal function by halting translation, degrading proteins, and activating signaling pathways that increase production molecular chaperones. cell-non-autonomous involves spreading signals from initially stressed cells neighboring unstressed lack stressor. Though viruses are known modulators UPR, recent advancements have highlighted plays critical role elucidating how local infections cause systemic effects, thereby contributing disease symptoms progression. Additionally, utilizing devised novel strategies establish pro-viral state, promoting virus spread. This review discusses examples broadened understanding progression looking beyond non-autonomous processes mechanistic details inducers, spreaders, receivers signals.

Language: Английский

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A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 134 - 134

Published: Jan. 8, 2025

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies head and neck (HNSCC). HNSCC recognized as eighth commonly occurring cancer globally in men. It essential to distinguish between cancers arising regions due significant differences their etiologies, treatment approaches, prognoses. As Cancer Genome Atlas (TCGA) dataset available HNSCC, survival analysis prognosis OSCC patients based on TCGA for discovering gene expression-based prognostic biomarkers limited. To address this paucity, we aimed provide comprehensive evidence by recruiting studies that have reported new biomarkers/signatures establish a model predict patients. Using PubMed search, identified 34 been using least absolute shrinkage selection operator (LASSO)-based Cox regression analyses signature related different pathways from past 4 years. Our review was focused summarizing these signatures implications targeted therapy FDA-approved drugs. Furthermore, conducted an LASSO signatures. findings revealed 13 correlated greater number regulatory T cells (Tregs) protective with increased recurrence-free overall rates. Conversely, two displayed opposing trend cases OSCC. We will also explore how dysregulation impacts immune status, promoting tumor evasion or, conversely, enhancing surveillance. Overall, insight future anti-cancer therapies potential associated poor

Language: Английский

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