The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 743 - 743

Published: July 11, 2024

Background: Type 2 diabetes mellitus (T2DM) is becoming a major global health concern, especially in developing nations. The high prevalence of obesity and related cases are attributed to rapid economic progress, physical inactivity, the consumption high-calorie foods, changing lifestyles. Objectives: We investigated roles pro-inflammatory chemokines CCL1, 2, 4, 5 T2DM with varying levels Asir region Saudi Arabia. Materials Methods: In total, 170 confirmed subjects normal control group were enrolled. Demographic data, serum CCL-1, 5, biochemical indices assessed groups by standard procedures. Results: divided into four groups: A (normal body weight), B (overweight), C (obese), D (highly obese). observed that male female had similar mean concentrations 5. all showed significantly higher compared controls, regardless gender. severe obesity, rise was most significant. There progressive 4 increasing BMI. Serum CCL5 increased subject groups. increase more predominant normal-weight people, overweight obese subjects. Conclusions: Male blood three BMI supports idea dyslipidemia contribute chronic inflammation insulin resistance. selective pronounced BMI, degrees rather surprising. Further research needed determine if underexpression due some unexplained counterbalancing processes.

Language: Английский

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Nailfold capillary abnormalities as indicators of diabetic nephropathy progression: a cross-sectional study in type 2 diabetes

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Feb. 3, 2025

Background Type 2 diabetes mellitus (DM) leads to chronic hyperglycemia and microvascular complications, including diabetic nephropathy (DN). Nailfold videocapillaroscopy (NVC) is a non-invasive method for assessing the abnormalities may aid in early DN detection. This study investigates correlation between nailfold capillary type DM.

Language: Английский

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PRKD2 as a novel target for targeting the diabetes–osteoporosis nexus

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 8, 2025

Diabetes mellitus (DM) and osteoporosis (OP) co-morbidity (DMOP) pose major health challenges owing to their complex pathophysiological interactions. The aim of this study was identify validate key genes implicated in the pathogenesis both conditions. By employing Mfuzz time-series gene clustering method combined with transcriptome sequencing patient serum, we systematically delineated expression patterns during transition from a healthy state through DM DMOP. These findings were further validated using external datasets, series functional enrichment analyses, set immune cell infiltration studies conducted. Our analyses revealed distinct progression pattern normal DMOP, characterized by dynamic changes. Notably, PRKD2 emerged as significantly downregulated highlighting its crucial role disease pathogenesis. Further involvement signaling pathways, especially Wnt IL-18 which are critical for bone glucose metabolism. Validation cellular animal models confirmed apoptosis metabolism, emphasizing therapeutic potential. In conclusion, our establish pivotal molecule offering fresh insights into mechanisms affirming value target.

Language: Английский

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ZHX2 inhibits diabetes-induced liver injury and ferroptosis by epigenetic silence of YTHDF2

Nutrition and Diabetes, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of type 2 diabetes mellitus (DM). The transcription factor zinc fingers and homeoboxes (ZHX2) has been implicated in the pathogenesis chronic diseases, yet its precise role underlying mechanism DM-induced hepatic injury remain poorly elucidated. To investigate this, we used high-fat diet (HFD) streptozotocin (STZ) administration to create DM model mice, while high glucose (HG) exposure was simulate vitro. Through various experiments such as luciferase reporter assay, chromatin immunoprecipitation, RNA rescue experiments, aimed uncover mechanisms involving ZHX2. Our findings revealed that ZHX2 lower YTHDF2 higher livers mice HG-induced Huh7 cells. overexpression rescued injury. also reversed ferroptosis vivo Mechanistically, recognized m6A-modified mRNA promoted degradation. In turn, inhibited by binding promoter region. Knockdown led increased cells through activating YTHDF2-induced GPX4 SLC7A11 These highlight involvement ZHX2-YTHDF2-ferroptosis pathway suggest targeting this may hold therapeutic potential for improving injuries.

Language: Английский

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Identification of aldose reductase inhibitors from the flowers of Tussilago farfara using PCN-222 metal-organic framework-based immobilization-free affinity selection coupled with high-performance liquid chromatography

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1748, P. 465879 - 465879

Published: March 15, 2025

Language: Английский

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Study of the efficacy and the mechanism of action of lanreotide for the treatment of persistent diabetic macular edema

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

The current treatments for diabetic macular edema (DME) include laser, steroids or vascular endothelial growth factors inhibitors (antiVEGF). Some DME are resistant to these treatments, which can respond somatostatin such as lanreotide. These drugs appear influence the development of retinopathy (DR) and either through a direct antiVEGF effect inhibition hormone (GH), cell apoptosis anti-inflammatory effect. It was conducted study effects lanreotide in retinal pigment epithelial cultures clinical patients with conventional order better understand usefulness this drug. Lanreotide showed antiapoptotic significantly improved visual acuity. could be applied non-respondent other an alternative refractory patients.

Language: Английский

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Myiasis einer Wunde unter extremen Hitzebedingungen

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

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Electro‐ and Magneto‐Active Biomaterials for Diabetic Tissue Repair: Advantages and Applications

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance

Language: Английский

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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Predicting isolated impaired glucose tolerance without oral glucose tolerance test using machine learning in Chinese Han men

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

Isolated Impaired Glucose Tolerance (I-IGT) represents a specific prediabetic state that typically requires standardized oral glucose tolerance test (OGTT) for diagnosis. This study aims to predict status in Chinese Han men at fasting using machine learning (ML) models with demographic, anthropometric, and laboratory data. The population consisted of 1,117 aged 50-87 years. Baseline variables including age, plasma (FPG), high blood pressure (HBP), body mass index (BMI), waist hip ratio (WHR), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density (LDL-C) were collected from electronic medical records (EMRs) model training validation. Support Vector Machine (SVM), Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), K-Nearest Neighbors (KNN), Naive Bayes (NB), Adaptive Boosting (AdaBoost) Gradient Machines (GBM) tested performance comparison. Model was evaluated metrics accuracy, recall, F1 score, positive predictive value (PPV), negative (NPV), the area under receiver operating characteristic curve (AUC). Shapley Additive Explanations (SHAP) confusion matrix plots used interpretation. RF demonstrated best overall 96.7% recall 91.4%, score 95.7%, PPV 99.1%, NPV 95.6%. AUC values SVM, DT, RF, LR, KNN, NB, AdaBoost, GBM 0.97, 0.92, 0.96, 0.88, respectively. While showed strong performance, LR had highest AUC, indicating superior discriminatory power. FPG identified as most important predictor I-IGT, followed by HDL, TC, HBP, BMI, WHR. Individuals levels higher than 5.1 mmol/L more likely have I-IGT; this cut-off were: 89.35% 89.79% 85.22% 81.09% PPV, 94.38% NPV, 0.95 AUC. based on demographic clinical characteristics offer cost-effective method predicting I-IGT over 50, without need an OGTT. These could complement existing early diagnostic strategies, thereby enhancing detection prevention diabetes. Additionally, alone serve efficient screening tool identification settings.

Language: Английский

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