Diabetes as a risk factor for MASH progression

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 217, P. 111846 - 111846

Published: Sept. 6, 2024

Language: Английский

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Bidirectional Association of Gut Microbiota-Derived Trimethylamine N-Oxide and its Precursors with Estimated Glomerular Filtration Rate: A Cross-Lagged Cohort Study

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

It is unclear whether Trimethylamine N-oxide (TMAO) and its precursors are bidirectionally associated with kidney dysfunction. This study aims to investigate increased TMAO linked decreased eGFR reduced elevated precursors. Our consists of participants creatinine, TMAO, (choline, carnitine, betaine) repeatedly measured from Fuxin Rural Cohort. We utilized cross-lagged panel models (CLPM) assess the potential bidirectional associations eGFR. Age-(≥60 <60 years) sex-specified interaction effects were examined using multi-group CLPMs. Bonferroni method was applied for multiple comparison. Of 1746 (mean age 59.4 ± 9.3 years, 584 (33%) male), inversely related after two years (Cross-Lagged Coefficient, 95% CI: -0.030, -0.058 -0.002, P=0.035), negatively carnitine (-0.138, -0.198 -0.078, P<0.001). Subgroup analysis showed significant between baseline in individuals aged 60 older (-0.061, -0.107 -0.014, P=0.011), (-0.093, -0.164 -0.022, P=0.010), those under (-0.153, -0.226 -0.079, P<0.001), females (-0.154, -0.229 Additionally, nominally choline (0.092, 0.017 0.167, P=0.017) males (0.114, 0.015 0.213, P=0.025). Deceased serum level may be choline. Conversely, function. provides novel evidence that managing healthy function helps keep at optimal levels, while maintaining low levels reduces risk disease.

Language: Английский

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Research Progress of Non-Alcoholic Fatty Liver Disease from the Perspective of Intestinal Flora

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 477 - 490

Published: Jan. 1, 2025

Language: Английский

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Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN

Journal of Diabetes, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 1, 2025

ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with complex pathogenesis. Methods Recent studies were reviewed to explore the role gut microbiota and its metabolites in DN development. Results Dysbiosis bacteria contributes pathological changes such as glomerular sclerosis renal tubule injury. Microbial are involved through immune inflammatory pathways. Conclusions Understanding relationship between microbiota, metabolites, may offer potential implications for diagnosis, prevention, treatment. Translating this knowledge into clinical practice presents challenges opportunities.

Language: Английский

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The Role of the Gut Microbiota in Heart Failure: Pathophysiological Insights and Future Perspectives

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 720 - 720

Published: April 14, 2025

The gut microbiota has emerged as a crucial player in cardiovascular diseases, including heart failure (HF). Recent studies have highlighted the bidirectional interaction between and heart, often referred to gut–heart axis. Dysbiosis, characterized by alterations microbial composition function, been linked systemic inflammation, metabolic disturbances, impaired homeostasis. This review explores mechanisms through which influences HF, metabolite production, inflammatory pathways, endothelial dysfunction, hormonal modulation, fluid retention, sodium absorption. potential therapeutic implications of modulation diet, probiotics, pharmacological interventions are also discussed. Understanding these could pave way for novel diagnostic strategies management HF. Future research should focus on longitudinal establish causality development personalized microbiota-based interventions.

Language: Английский

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Elevated Circulating Levels of Gut Microbe-Derived Trimethylamine N-Oxide Are Associated with Systemic Sclerosis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(19), P. 5984 - 5984

Published: Oct. 8, 2024

Alterations in fecal microbial communities patients with systemic sclerosis (SSc) are common, but the clinical significance of this observation is poorly understood. Gut production trimethylamine (TMA), and its conversion by host to

Language: Английский

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Gut microbiome and inflammation in cardiovascular drug response: trends in therapeutic success and commercial focus

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

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