Elevated glucose levels increase vascular calcification risk by disrupting extracellular pyrophosphate metabolism DOI Creative Commons

Alicia Flores-Roco,

Belinda M Lago,

Ricardo Villa‐Bellosta

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 11, 2024

Vascular calcification is a major contributor to cardiovascular disease, especially diabetes, where it exacerbates morbidity and mortality. Although pyrophosphate recognized natural inhibitor of vascular calcification, there have been no prior studies examining its specific deficiency in diabetic conditions. This study the first analyze direct link between elevated glucose levels disruptions extracellular metabolism.

Language: Английский

The Potential Role of Advanced Glycation End Products in the Development of Kidney Disease DOI Open Access
Yibin Ma, Xinyu Wang, Shan Lin

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 758 - 758

Published: Feb. 21, 2025

Advanced glycation end products (AGEs) represent a class of toxic and irreversible compounds formed through non-enzymatic reactions between proteins or lipids carbonyl compounds. AGEs can arise endogenously under normal metabolic conditions in pathological states such as diabetes, kidney disease, inflammatory disorders. Additionally, they be obtained exogenously dietary intake, particularly from foods high fat sugar, well grilled processed items. accumulate various organs have been increasingly recognized significant contributors to the progression numerous diseases, disease. As plays crucial role AGE metabolism excretion, it is highly susceptible AGE-induced damage. In this review, we provide comprehensive discussion on onset including diabetic nephropathy, chronic acute injury. We explore potential biological mechanisms involved, accumulation, AGEs-RAGE axis, oxidative stress, inflammation, gut microbiota dysbiosis, DNA Furthermore, discuss recent findings characteristics vivo their pathogenic impact renal function. examine clinical significance early diagnosis, treatment, prognosis highlighting biomarkers therapeutic targets. By integrating advancements research, review aims new insights strategies for mitigating AGE-related damage improving disease management.

Language: Английский

Citations

1
Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review DOI Creative Commons
Xiaoli Liu,

Sailu Mao,

Yuxue Yuan

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Diabetic cognitive dysfunction is one of the important comorbidities and complications diabetes, which mainly manifested by loss learning ability memory, behavioural disorders, may even develop into dementia. While traditional anti-diabetic medications are effective in improving cognition long-term use these can be accompanied undesirable side effects. Therefore, there an urgent need to find safe alternative therapies. Accumulating evidence suggests that phytogenic bioactive peptides play role regulation diabetes. In this review, we explored relationship between diabetes mellitus dysfunction, potential underlying mechanisms plant-derived improve diabetic dysfunction. We found active alleviate impairment inhibiting key enzymes (e.g., α-glucosidase, α-amylase) blood glucose levels increase antioxidant activity, modulate inflammatory mediators, address intestinal dysbiosis. conclusion, show strong impairment.

Language: Английский

Citations

0
Causes, Diagnosis, Treatment, and Prognosis of Cardiac Fibrosis: A Systematic Review DOI Open Access

Hasan A BaniHani,

Lana H Khaled,

Nada M Al Sharaa

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Cardiac fibrosis, characterized by excessive extracellular matrix deposition, contributes to heart failure, arrhythmias, and myocardial dysfunction. Despite advances in understanding its mechanisms, targeted antifibrotic therapies remain limited. This review examines the causes, molecular diagnostic approaches, therapeutic strategies for cardiac fibrosis. A systematic of peer-reviewed studies was conducted, focusing on etiology, diagnosis, treatment, prognosis fibrosis with no specific timeframe. The condition is driven fibroblast activation, inflammatory pathways, mechanical stress, key contributing factors including ischemic disease, hypertension, diabetes, aging. Diagnostic tools such as magnetic resonance imaging T1 mapping biomarkers play a crucial role, natriuretic peptides offering both prognostic value. Galectin-3 has also shown promise marker. Current therapies, RAAS inhibitors beta-blockers, help prevent progression but do not reverse established Emerging plant-based compounds, gene therapy, fibroblast-targeting vaccines, stem cell reprogramming show potential preclinical studies. However, remains major driver disease progression, existing treatments Major gaps include lack validated agents challenges translating findings into clinical applications. Further research essential develop effective interventions.

Language: Английский

Citations

0
From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy DOI Creative Commons
Bin Liu, Qing Jin, Yi Sun

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.

Language: Английский

Citations

0
Diabetes mellitus, Obesity and Periodontitis – A three way interconnection DOI Creative Commons

V Pavithra,

Sri Chinthu KK,

Matthew D. Solomon

et al.

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100615 - 100615

Published: May 1, 2025

Language: Английский

Citations

0
Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats DOI
Neha Rani, Dharamvir Singh Arya

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Objective Advanced glycation end products/receptor for AGEs (AGE/RAGE) signaling has a well-established role in the etiology of diabetic-related cardiovascular disorders. The purpose study was to elucidate chrysin, peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, against ischemia/reperfusion (IR) injury diabetic rats and its functional interaction with AGE/RAGE pathway. Methods A single intraperitoneal injection streptozotocin (STZ, 70 mg/kg) administered induction diabetes. Rats having blood glucose levels more than 300 mg/dl following 72 hr STZ were classified as diabetic. PPAR-γ antagonist GW9662 (1 mg/kg, i.p.), chrysin (60 p.o.), or both 4 weeks. On 29th day, given ischemia 45 min then reperfusion 1 induce myocardial infarction (MI). Key findings Pretreatment significantly improved hemodynamic status, ventricular functions, cardiac markers myocardium. Increased PPAR-γ/Nrf2 decreased RAGE protein expressions linked this improvement. Chrysin pretreatment resulted upregulation endogenous antioxidants reduced TBARS levels. Moreover, inflammation apoptosis Conclusion co-activation by ameliorated IR-induced MI rats, possibly via modulating signaling.

Language: Английский

Citations

0
Untargeted Metabolite Profiling Reveals Acute Toxicity of Pentosidine on Adipose Tissue of Rats DOI Creative Commons
Chuanqin Hu,

Zhenzhen Shao,

Wei Wu

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(10), P. 539 - 539

Published: Oct. 9, 2024

: Pentosidine is an advanced glycation end product that commonly found in heat-processed foods. has been involved the occurrence and development of some chronic diseases. It was reported pentosidine exposure can impair function liver kidneys. Adipose tissue, as active endocrine organ, plays important role maintaining normal physiological cells. However, metabolic mechanism causes to induce toxicity adipose tissue remains unclear.

Language: Английский

Citations

0
Elevated glucose levels increase vascular calcification risk by disrupting extracellular pyrophosphate metabolism DOI Creative Commons

Alicia Flores-Roco,

Belinda M Lago,

Ricardo Villa‐Bellosta

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 11, 2024

Vascular calcification is a major contributor to cardiovascular disease, especially diabetes, where it exacerbates morbidity and mortality. Although pyrophosphate recognized natural inhibitor of vascular calcification, there have been no prior studies examining its specific deficiency in diabetic conditions. This study the first analyze direct link between elevated glucose levels disruptions extracellular metabolism.

Language: Английский

Citations

0