Development of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis

Molecular Immunology, Journal Year: 2025, Volume and Issue: 178, P. 1 - 11

Published: Jan. 6, 2025

Language: Английский

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NAT10 induces mitochondrial dysfunction in lung epithelial cells by acetylating HMGB1 to exacerbate Pseudomonas aeruginosa-induced acute lung injury

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107364 - 107364

Published: Feb. 1, 2025

Language: Английский

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Theabrownins improve burn-induced kidney injury by increasing the levels of guanidinoacetic acid and fumaric acid

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156609 - 156609

Published: March 7, 2025

Language: Английский

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NAT10 Regulates LPS-Induced Inflammation via Stabilization of N4-Acetylated PTX3 mRNA in Human Dental Pulp Stem Cells

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4325 - 4325

Published: May 2, 2025

Severe dental pulp inflammation can lead to tissue lysis and destruction, underscoring the necessity for effective treatment of pulpitis. N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification has recently emerged as a key regulator in inflammatory processes. However, whether NAT10 affects response human stem cells (hDPSCs) remains unelucidated. In this study, elevated expression was observed pulpitis tissues LPS-stimulated hDPSCs. Knockdown led reduced gene lower reactive oxygen species (ROS) production hDPSCs, while chemotactic migration macrophages also suppressed. Similar results were when hDPSCs treated with Remodelin, an inhibitor NAT10. Differentially expressed genes identified through RNA sequencing significantly enriched signaling pathways after depletion. Among differential genes, pentraxins 3 (PTX3) potential target due presence ac4C site its known ability regulate inflammation. The mRNA protein levels PTX3 NAT10-deficient cells, along decrease stability. Exogenous supplementation partially reversed inhibition induced by knockdown. Further evidence vivo revealed that Remodelin attenuated severity rats summary, these data indicated deficiency inhibited stability further hDPSC inflammation, might be therapeutic agent capping.

Language: Английский

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Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 283, P. 117152 - 117152

Published: Dec. 8, 2024

Language: Английский

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