Fatty acid binding proteins and their involvement in anxiety and mood disorders DOI Creative Commons
Matthew Jones, Taygun C. Uzuneser, Steven R. Laviolette

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106952 - 106952

Published: May 1, 2025

Anxiety and mood disorders represent the most prevalent neuropsychiatric conditions. Nevertheless, current pharmacotherapies often have a host of adverse side effects. Emerging evidence suggests modulation lipid signaling pathways - particularly those involved in endocannabinoid (eCB) system, may offer promising new targets for treatment anxiety depression. Polyunsaturated fatty acids (PUFA) their metabolic derivatives, including eCB ligands, garnered significant attention roles disease mechanisms. Intracellular transportation these lipids is facilitated by acid binding proteins (FABP), which are increasingly recognized as key regulators signaling. Accumulating indicates that FABPs impact development mediating PUFAs ligands. In this review, we investigate role two major categories conditions clinical We begin examining several neuropathophysiological mechanisms through can conditions, focusing on chaperones. These include trafficking well oleoylethanolamide palmitoylethanolamide; inflammatory responses PUFA transport PPAR activation; regulation availability to support neurogenesis; influence stress-related pathways, NMDA receptor activation hypothalamic-pituitary-adrenal axis; facilitation dopamine localization. Next, discuss preclinical linking FABP function anxiety- depression-related behaviours. Finally, propose pharmacologically targeting FABP-mediated holds considerable potential novel therapeutic strategy addressing symptoms associated with disorders.

Language: Английский

Safety Evaluation of Fermented and Nonfermented Moringa oleifera Seeds in Healthy Albino Rats: Biochemical, Haematological, and Histological Studies DOI Creative Commons
Foluso Olutope Adetuyi, Emmanuel Sina Akintimehin, Kayode Olayele Karigidi

et al.

International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Fermentation preserves and enhances food properties, but consuming locally fermented foods can cause health issues like flatulence, gastrointestinal disorders, kidney stones, sometimes death. This study evaluated the biochemical, haematological, histological effects of supplementing diets with Moringa oleifera seed (FMS) nonfermented (NFMS) in healthy albino rats. Male rats were fed containing 10%, 20%, 30% FMS NFMS for 14 days. No significant changes observed body weight or organ/body ratios. However, platelet count increased significantly (p < 0.05) at higher supplementation levels, suggesting enhanced haemostatic activity. While haematological parameters remained stable, 20% urea creatinine indicating potential renal stress. Histological analysis showed mild alterations more pronounced NFMS-fed mitigated antinutrient effects, enhancing safety. are safe up to inclusion, applications human nutrition functional development.

Language: Английский

Citations

0
Melatonin-Mediated Protection against Sepsis-Induced Organ Dysfunction DOI
Hilal Üstündağ, Songül Doğanay

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Sepsis-induced organ dysfunction represents a critical challenge in intensive care medicine, characterized by complex pathophysiological mechanisms that can lead to multiple failure and death. This review examines the fundamental underlying sepsis-induced explores therapeutic potential of melatonin, multifaceted molecule with potent antioxidant anti-inflammatory properties. We analyzed pathways involved damage during sepsis, including inflammatory cascades, oxidative stress, mitochondrial dysfunction, endothelial injury. Special attention is given melatonin’s protective effects on various systems, cardiac, pulmonary, renal, hepatic, central nervous system function sepsis. Recent evidence suggests ability modulate these pathways, combined its excellent safety profile, makes it promising agent sepsis management. Understanding applications may provide new strategies for improving outcomes septic patients.

Language: Английский

Citations

0
Advances in pediatric sepsis biomarkers - what have we learnt so far? DOI
Wen‐Yu Su,

Miao Fan,

Wei Shen

et al.

Expert Review of Molecular Diagnostics, Journal Year: 2025, Volume and Issue: 25(5), P. 183 - 198

Published: April 30, 2025

Sepsis is a systemic immune dysregulation syndrome triggered by secondary infection in the host, with diagnosis based on updated Phoenix criteria and characterized multi-organ failure as its core pathological manifestation. It significant global health challenge due to increasing incidence high mortality rates. Recent advancements biomarker research provide promising tools for improving early timely intervention, essential better patient outcomes. This review examines latest developments pediatric sepsis biomarkers, categorized inflammation, metabolism, organ damage, non-coding RNAs (miRNAs, LncRNAs). We discuss each category, highlighting integration of diverse biomarkers advanced technologies enhance diagnostics, personalize therapy, improve stratification. Given limited specificity sensitivity current markers like CRP PCT, multicenter studies are crucial validating new developing comprehensive panel that combine multiple diagnostic indicators. also important consider variability host responses different pathogens when identifying host-pathogen interactions. To advance personalized medicine, future may prioritize identification specific sepsis, tailored pathogens.

Language: Английский

Citations

0
NINJ1 impairs the anti-inflammatory function of hUC-MSCs with synergistic IFN-γ and TNF-α stimulation DOI Creative Commons

Hu Wang,

Guomei Yang,

Luoquan Ao

et al.

Chinese Journal of Traumatology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Fatty acid binding proteins and their involvement in anxiety and mood disorders DOI Creative Commons
Matthew Jones, Taygun C. Uzuneser, Steven R. Laviolette

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106952 - 106952

Published: May 1, 2025

Anxiety and mood disorders represent the most prevalent neuropsychiatric conditions. Nevertheless, current pharmacotherapies often have a host of adverse side effects. Emerging evidence suggests modulation lipid signaling pathways - particularly those involved in endocannabinoid (eCB) system, may offer promising new targets for treatment anxiety depression. Polyunsaturated fatty acids (PUFA) their metabolic derivatives, including eCB ligands, garnered significant attention roles disease mechanisms. Intracellular transportation these lipids is facilitated by acid binding proteins (FABP), which are increasingly recognized as key regulators signaling. Accumulating indicates that FABPs impact development mediating PUFAs ligands. In this review, we investigate role two major categories conditions clinical We begin examining several neuropathophysiological mechanisms through can conditions, focusing on chaperones. These include trafficking well oleoylethanolamide palmitoylethanolamide; inflammatory responses PUFA transport PPAR activation; regulation availability to support neurogenesis; influence stress-related pathways, NMDA receptor activation hypothalamic-pituitary-adrenal axis; facilitation dopamine localization. Next, discuss preclinical linking FABP function anxiety- depression-related behaviours. Finally, propose pharmacologically targeting FABP-mediated holds considerable potential novel therapeutic strategy addressing symptoms associated with disorders.

Language: Английский

Citations

0