FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis

Redox Biology, Journal Year: 2025, Volume and Issue: 83, P. 103647 - 103647

Published: May 1, 2025

Drug resistance in colorectal cancer (CRC) poses a major challenge for therapy and stands as the primary cause of cancer-related mortality. The N6-methyladenosine (m6A) modification has emerged pivotal regulator biology, yet precise m6A regulators that propel CRC progression chemoresistance remain elusive. Our study established significant correlation between regulatory gene expression profiles severity. Notably, based on knockout cellular mouse model created by CRISPR/Cas9-mediated genome engineering, we identified demethylase FTO orchestrator through regulation NUPR1, critical transcription factor involved iron homeostasis via LCN2 FTH1. Mechanistic revealed stabilized NUPR1 mRNA specifically targeting +451 site, thereby preventing YTHDF2-mediated degradation mRNA. Moreover, simultaneous dramatically enhanced efficacy chemotherapy cells. findings underscore potential modulating methylome to overcome highlight FTO-NUPR1 axis determinant pathobiology.

Language: Английский

Coenzyme Q10 and rikkunshito prevent age-related changes in mouse otolith morphology and function

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 102033 - 102033

Published: May 1, 2025

Language: Английский

The role of insulin-like growth factor-1 in lactation

Gene, Journal Year: 2025, Volume and Issue: 962, P. 149577 - 149577

Published: May 20, 2025

Language: Английский