Comorbidities as risk factors for migraine onset: A systematic review and three‐level meta‐analysis

European Journal of Neurology, Journal Year: 2025, Volume and Issue: 32(3)

Published: March 1, 2025

Migraine is a debilitating neurological disease with multifaceted pathophysiology. Pre-existing comorbidities may influence the risk of developing migraine. This review and meta-analysis aim to present comprehensive overview known predisposing individuals new migraine onset, thereby improving our understanding respective diseases' interactions. A systematic search PubMed EMBASE identified studies on pre-existing as factors for onset. We performed three-level meta-analyses employing restricted maximum likelihood estimation calculate pooled ratios (pRR). Subgroup sensitivity analyses were conducted assess robustness data. Risk bias (RoB) was assessed Quality in Prognostic Studies Tool. pre-registered Prospero (CRD42024501140). From total 17,330 records, we 38 studies, encompassing 124 effect sizes from 58 exposures. Most (n = 28, 74%) had low RoB. Heterogeneity high (>90%), primarily due within-study differences (>50%), not significantly impacted by moderator tests or exclusion outliers. found increased risks onset associated prior atopic conditions [pRR 1.53 (1.15, 2.03)], psychiatric psychological disorders 2.63 (1.79, 3.85)], sleep 1.89 (1.26, 2.85)], cardiovascular 1.72 (1.07, 2.76)]. atopic, psychiatric, sleep, are likely shared genetic predisposition mediating like stress inflammation. Future research should focus these associations advance targeted prevention treatment strategies.

Language: Английский

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Treating episodic migraine with precision: the evolving landscape of targeted therapies driven by insights in disease biology

Expert Opinion on Biological Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 20, 2025

Migraine is a disabling neurological disorder with complex neurobiology. It appears as cyclic of sensory processing, affecting multiple systems beyond nociception. Overlapping mechanisms, including dysfunctional processing input from brain structures are involved in the generation attacks. This review provides comprehensive synthesis on migraine neurobiology, which was additionally informed by search research databases (PubMed, ClinicalTrials.gov). Findings most recent literature integrated pathophysiological framework. By combining mechanistic insights and clinical trial data, this highlights trajectory precision medicine treatment, offering perspective near future targeted individualized therapeutic strategies. Recent advances neurobiology offer potential solutions to longstanding challenges. While CGRP therapies have shown promise addressing specific pathophysiology suggests that combination targeting pathways could be beneficial prevention. The growing diversity treatment options presents challenges therapy selection, underscoring need for predictive biomarkers. These innovations can optimize strategies improve patient outcomes. As field progresses, personalized, multimodal approaches poised become standard care, significantly advancing area.

Language: Английский

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An analysis of the burden of migraine and tension-type headache across the global, China, the United States, India and Japan

Frontiers in Pain Research, Journal Year: 2025, Volume and Issue: 6

Published: Feb. 3, 2025

Background Recurrent headaches in headache disorders adversely impact quality of life and job. Migraines tension-type TTH) are the most common primary a prominent cause disability globally. However, few research compare illness burden China, India, United States (US), Japan. Methods Global Chinese, US, Indian, Japanese migraine TTH incidence, prevalence, disability-adjusted years were taken from GBD database for 1990–2021. The data is studied utilizing decomposition analysis, health inequality research, joinpoint regression model, Bayesian Average Annual Percentage Change (BAPC) model. Results study found that mostly affects women aged 15–49, while evenly distributed across gender age. worldwide average annual percentage change (AAPC) disease-adjusted (DALYs) 1990 to 2021 was 0.0357, statistically significant trend ( p < 0.001), as determined using analysis. China exhibited quickest rise incidence well age-standardized rate (ASR) DALYs, four nations analyzed. US had highest value these indicators. Forecasting models reveal without policy action, prevalence will grow but would stay unchanged. Decomposition showed population expansion major migraines TTH, which be slightly alleviated by aging. Health disparities economic growth areas lessened between 2021, according report. Conclusion Globally have increased since 1990. becoming more young middle-aged women, so treatment professionals should invest patient education raise awareness improve self-management reduce disease medical costs.

Language: Английский

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Menopause, Perimenopause, and Migraine: Understanding the Intersections and Implications for Treatment

Neurology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Migraine affects women three times more often than it does men, and various mechanisms may explain this incidence, including the key role of female sex hormones. Fluctuations in levels these hormones their feedback control regulate menstrual cycle, pregnancy, puerperium, perimenopause, menopause. They can influence occurrence severity migraine throughout reproductive period. Of particular importance seems to be perimenopausal period, which is associated with an increase migraine, especially considered disabling less amenable treatment non-menstrual attacks. This article reviews available evidence documenting relationship between menopause, diagnostic considerations attempt determine management periods a woman's life. Special considerations, future directions, unmet needs for menopausal are also discussed.

Language: Английский

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Migraine with and without aura—two distinct entities? A narrative review

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 14, 2025

Language: Английский

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Susceptibility Weighted Imaging as a Biomarker for Cortical Spreading Depression

Clinical and Translational Neuroscience, Journal Year: 2025, Volume and Issue: 9(1), P. 3 - 3

Published: Jan. 20, 2025

Introduction: Cortical spreading depression (CSD) is thought to be the pathophysiologic correlate of migraine aura. In experimental animals, CSD was shown cause an increase in oxyhemoglobin. Susceptibility weighted imaging (SWI) on magnetic resonance (MRI) depicts cerebral veins according their concentration The aim this study assess whether distribution SWI changes people with aura resembles clinical presentation, a focus topology. Methods: retrospective single-center study, patients were included if they (i) had acute focal neurological symptoms beginning visual symptoms, (ii) underwent head MRI including within eight hours symptom onset, (iii) showed dilated veins, and (iv) discharge diagnosis Eleven predefined regions interest (ROIs) assessed for prominent (PFVs) SWI. We determined correlated topography ROIs PFVs. Results: found posterior anterior gradient during when present. Conclusion: might able detect traces CSD. areas corresponds anatomically canonical succession

Language: Английский

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fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura

Neurology International, Journal Year: 2025, Volume and Issue: 17(2), P. 15 - 15

Published: Jan. 21, 2025

Migraine with aura (MwA) is a common and severely disabling neurological disorder, characterised by transient yet recurrent visual disturbances, including scintillating scotomas, flickering photopsias, complex geometric patterns. These episodic phenomena significantly compromise daily functioning, productivity, overall quality of life. Despite extensive research, the underlying pathophysiological mechanisms remain only partially understood. Cortical spreading depression (CSD), propagating wave neuronal glial depolarisation, has been identified as central process in MwA. This phenomenon triggered ion channel dysfunction, leading to elevated intracellular calcium levels excessive glutamate release, which contribute widespread cortical hyperexcitability. Genetic studies, particularly involving CACNA gene family, further implicate dysregulation channels pathogenesis Recent advances neuroimaging, functional magnetic resonance imaging (fMRI), have provided critical insights into neurophysiology results support role CSD basic mechanism behind MwA imply that dysfunction endures beyond brief episodes, possibly due chronic or The cortex patients exhibits activation patterns comparison other neuroimaging supporting possibility it disease-specific biomarker. Its distinctive sensory cognitive characteristics are influenced interplay cortical, vascular, genetic factors, demonstrating multifactorial nature We now know much more about pathophysiology thanks combination molecular research sophisticated techniques like arterial spin labelling (ASL) fMRI. review aims synthesize current knowledge analyse neurophysiological targets, providing foundation for developing targeted therapies modulate excitability, restore neural network stability, alleviate burden migraine aura. most important impactful our field focus this review, highlights developments their contributions treatment

Language: Английский

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Fitness-to-work considerations in the paradigmatic pain condition of headache disorder

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 31, 2025

Headache disorders are common, including in the working population. Clinicians caring for patients with headache need to be aware of work-related factors as potential causes or triggers disorders, and consider impact on fitness-to-work, especially safety-sensitive decision-critical roles. Such fitness-to-work determination should include individualized consideration nature disorder itself, pattern headache, sleep deprivation it relates fitness do shiftwork, medication substance side effects, implications associated medical psychiatric conditions, symptom feigning malingering secondary gain. As clinicians often struggle determinations, a structured approach assessments conditions other pain would improve clarity increase quality care provided patients, benefits workplace safety policy this arena well.

Language: Английский

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Association between wine consumption and migraine: a systematic review and meta-analysis of cross-sectional

Alcohol and Alcoholism, Journal Year: 2025, Volume and Issue: 60(2)

Published: Jan. 19, 2025

It seems that diet is one of the main triggers migraine; most studied alcohol, and also, over years, red wine has been shown to trigger headaches. Therefore, this systematic review meta-analysis aims examine strength association between consumption migraine. In meta-analysis, a search MEDLINE (via PubMed), Scopus, Cochrane, Web Science databases was conducted assess migraine, covering baseline December 2023. Pooled Odds Ratio (p-OR) were calculated using DerSimonian Laird methods. This study previously registered in PROSPERO (CRD42024511115). The risk bias evaluated Quality Assessment Tool for Observational Cohort Cross-Sectional Studies. Five studies included review, only four them meta-analysis. Using method, p-OR effect on migraine 0.63 (95% CI 0.36-1.09). after assessment showed moderate bias. findings indicate there no conclusive evidence support an increased or decreased associated with consumption.

Language: Английский

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The burden of migraine in Mexico: a database analysis of migraine-related visits to emergency departments in Mexico’s ministry of health (MMoH) hospitals

Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Background The burden of migraine in Mexican Emergency Department (ED) settings remains understudied. This study aimed to determine the frequency migraine-related ED visits within Ministry Health's (MMoH) database and analyze their demographics treatment patterns.

Language: Английский

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