Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1093 - 1093

Published: Feb. 29, 2024

Luteolin, a flavonoid, is mainly found in various vegetables and fruits, including carrots, cabbages, onions, parsley, apples, broccoli, peppers. Extensive research vivo vitro has been performed to explore its role disease prevention treatment. Moreover, this compound possesses the ability combat cancer by modulating cell-signaling pathways across types of cancer. The studies have confirmed that luteolin can inhibit cancer-cell survival proliferation, angiogenesis, invasion, metastasis, mTOR/PI3K/Akt, STAT3, Wnt/β-catenin, cell-cycle arrest, induce apoptosis. Further, scientific evidence describes plays vital up/down-regulation microRNAs (miRNAs) therapy. This review aims outline anti-cancer mechanisms molecular targets. However, knowledge gap remains regarding on safety efficacy clinical trials. Therefore, it essential conduct more based safety, efficacy, trials beneficial management,

Language: Английский

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Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 200 - 200

Published: Feb. 10, 2025

Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, extending shelf life. The effectiveness of PPs has different molecular biological reasons, predominantly linked to their hydroxyl groups electron delocalization, which interact with microbial cell membranes, proteins, organelles. These interactions may reduce the efficiency metabolic pathways, cause destructive damage membrane, or they harm proteins nucleic acids foodborne bacteria. Moreover, exhibit distinctive ability form complexes metal ions, further amplifying activity. This narrative review explores complex multifaceted between pathogens, underlying correlation chemical structures mechanisms action. Such insights shed light on potential innovative natural preservatives within systems, presenting an eco-friendly sustainable alternative synthetic additives.

Language: Английский

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Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1566 - 1566

Published: Aug. 13, 2022

(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses wide variety actions. EGCG acts as strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH oxidase, activates systems superoxide dismutase, catalase, or glutathione, and reduces abundant production nitric oxide metabolites by inducible synthase. ECGC also exerts potent anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, metabolic effects via modulation intracellular signaling cascades. Based on this knowledge, the use could be benefit in respiratory diseases with acute chronic inflammatory, oxidative, fibrotizing processes their pathogenesis. This article reviews current information biological those animal models has been administered, i.e., distress syndrome, infections, COVID-19, bronchial asthma, obstructive pulmonary disease, lung fibrosis, silicosis, cancer, hypertension, embolism, critically discusses effectiveness administration these disorders. For review, articles English language from PubMed database were used.

Language: Английский

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Chemico-biological aspects of (−)- epigallocatechin- 3 -gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(30), P. 10382 - 10411

Published: May 2, 2022

Natural products have been a bedrock for drug discovery decades. (−)-Epigallocatechin-3-gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from green tea. It key component believed to be responsible medicinal value Significant studies implemented in vitro, cellulo, and vivo models suggested its anti-oxidant, anti-cancer, anti-diabetic, anti-inflammatory, anti-microbial, neuroprotective activities etc. Despite having such wide array therapeutic potential promising results preclinical studies, applicability humans has encountered with rather limited success largely due poor bioavailability, membrane permeability, rapid metabolic clearance lack stability EGCG. Therefore, novel techniques are warranted address those limitations so that EGCG or modified analogs can used clinical setup. This review comprehensively covers different strategies as structural modifications, nano-carriers efficient delivery systems, synergistic other bioactivities improve chemico-biological aspects (e.g., stability, etc.) enhanced pharmacokinetics pharmacological properties, eventually enhancing potentials. We think this article will serve strong platform comprehensive literature on development bioavailability it translated applications.

Language: Английский

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Lectins and lectibodies: potential promising antiviral agents

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: May 13, 2022

Abstract In nature, lectins are widely dispersed proteins that selectively recognize and bind to carbohydrates glycoconjugates via reversible bonds at specific binding sites. Many viral diseases have been treated with due their wide range of structures, specificity for carbohydrates, ability carbohydrates. Through hemagglutination assays, these can be detected interacting various on the surface cells envelopes. This review discusses most robust rationally engineered versions, such as lectibodies, antiviral proteins. Fusion lectin antibody’s crystallizable fragment (Fc) immunoglobulin G (IgG) produces a molecule called “lectibody” act carbohydrate-targeting antibody. Lectibodies not only glycoproteins neutralize clear viruses or infected by but also perform Fc-mediated antibody effector functions. These functions include complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated (ADCC), phagocytosis (ADCP). addition entering host cells, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein S1 binds angiotensin-converting enzyme (ACE2) downregulates it type I interferons in way may lead lung disease. The SARS-CoV-2 human immunodeficiency virus (HIV) envelope heavily glycosylated, which could make them major target developing vaccines, diagnostic tests, therapeutic drugs. neutralization clearance glycans located (e.g., glycosylated protein).

Language: Английский

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Medicinal plants with anti-colorectal cancer bioactive compounds: Potential game-changers in colorectal cancer management

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113383 - 113383

Published: July 9, 2022

Language: Английский

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Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: July 26, 2022

Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, inflammatory responses. Some these processes can contribute to cancer progression neurodegeneration. Owing the complexity this its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, majority JAK–STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety plant polyphenols, especially quercetin, exert their inhibitory effects on JAK–STAT through known unknown mechanisms. Quercetin shown prominent terms anti-inflammatory antitumor activity, well control neurodegenerative diseases. This review discusses pharmacological quercetin signaling solid tumors

Language: Английский

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Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2056 - 2056

Published: Nov. 29, 2023

Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in oncological applications phytochemicals, particularly polyphenols, resveratrol-a naturally occurring polyphenolic stilbene derivative-has emerged as a candidate interest. This review analyzes pleiotropic anti-cancer effects resveratrol, including its modulation apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, metastasis, interaction with cancer stem cells tumor microenvironment. The resveratrol on mitochondrial functions, which are crucial development, also discussed. Future research directions identified, elucidation specific molecular targets, facilitate clinical translation prevention therapy.

Language: Английский

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The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 21, 2023

Abstract Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of illnesses characterized by the anomalous proliferation cells in bone marrow microenvironment (BMM). The BMM plays pivotal role promoting AML progression, angiogenesis, metastasis. immune checkpoints (ICs) metabolic processes are key players this process. In review, we delineate checkpoint characteristics BMM, with focus on roles e.g. tumor-associated macrophages, natural killer cells, dendritic profiles related signaling pathways. We also discuss pathways stimulated factors that lead to progression. then delve into metastasis, cell proliferation, including co-stimulatory inhibitory ICs. Lastly, potential therapeutic approaches future directions for treatment, emphasizing targeting as prognostic targets. conclusion, modulation these through use directed drugs opens up new promising avenues combating AML. Thereby, comprehensive elucidation significance cells' leukemic can be undertaken investigations. Additionally, should considered plausible multi-targeted therapies combination other conventional treatments

Language: Английский

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Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

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