Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 5, 2024
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown.
Language: Английский
Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754
Published: Jan. 1, 2025
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 13, 2025
Eucommia ulmoides Oliv ( E. ) is a widely distributed plant with economic value, nutritional edible value and even medicinal value. In recent years, polysaccharides are considered to be one of the most important bioactive ingredients in . Modern pharmacological studies show that crude extract polysaccharides, their active monomer ramifications have wide range activities vitro vivo experiments, which can used improve inflammation, regulate immunity, osteoporosis, promote osseointegration, etc. Therefore, this review focuses on induction summary research at home abroad summarizes extraction purification, modification methods, physicochemical properties, biological potential mechanisms providing theoretical basis for in-depth study development related products.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: May 8, 2025
Genome editing technologies, particularly CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), have broadened the possibilities of genetic research and molecular biology by enabling precise modifications genome, offering novel therapeutic potential for various disorders. Herein, we present an overview traditional genome techniques delve deeper into toolbox, with particular attention given to epigenetic transcriptional regulation. In context intervertebral disc (IVD), offers unprecedented approach address mechanisms underlying tissue degeneration, advancing development revolutionary therapies Low Back Pain (LBP). As so, showcase how leverage systems IVD. This cutting-edge technology has been successfully used improve our understanding IVD through functional studies disease modeling. Most relevant prioritizes new targets associated extracellular matrix (ECM), pain sensing or inflammatory pathways. Promising applications encompass regeneration recapitulation a regenerative environment targeting important degenerative catalysts. future, priority should be fetal gene reactivation, multiple healthy expression enhancement disease-associated polymorphisms' correction. Despite several challenges such as effective delivery, off-target effects, well ethical safety concerns, exciting clinical trials are anticipated in years come, providing more long-lasting solutions degeneration.
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 67 - 94
Published: April 25, 2025
Aging is a complicated process influenced by various factors that disturb cellular function and alter organism equilibrium over time. This chapter provides an updated overview, focusing on mechanisms like genomic instability, telomere attrition, mitochondrial failure, DNA damage buildup. Cellular senescence addressed in age-related illnesses, highlighting irreversible cell cycle arrest pro-inflammatory aspects. Epigenetic processes, specifically methylation inherited histone modifications, contribute to phenotypes. Longevity research covers FOXO, SIRT, autophagy. Nutrient-sensing pathways the microbiome's role aging are explored, along with therapeutic interventions targeting these pathways. synthesis of recent discoveries genetics, molecular biology, translational comprehensive perspective biology future clinical applications. By integrating insights from fields, this aims develop innovative strategies promote healthy longevity.
Language: Английский
Citations
0
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(4), P. 1028 - 1049
Published: March 12, 2025
The development of precise and efficient delivery systems is pivotal for advancing CRISPR/Cas9 gene-editing technologies, particularly therapeutic applications. Engineered metal-organic frameworks (MOFs) have emerged as a promising class inorganic nonviral vectors, offering unique advantages such tunable porosity, high cargo-loading capacity, biocompatibility. This review explores the design application MOF-based nanoplatforms tailored targeted components, aiming to enhance precision efficiency. By incorporating stimuli-responsive linkers bioactive ligands, these MOFs enable controlled release payloads at target site. Comparative discussions demonstrate superior performance over conventional in terms stability, transfection efficiency, reduced off-target effects. Additionally, intracellular trafficking mechanisms potential platforms preclinical models are discussed. These findings highlight transformative overcoming challenges associated with immunogenicity cytotoxicity, paving way their medicine. provides blueprint integration nanotechnology genome editing, frontier systems.
Language: Английский
Citations
0
Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2052 - 2052
Published: Dec. 12, 2024
Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.
Language: Английский
Citations
1
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 5, 2024
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown.
Language: Английский
Citations
0