Energy and Environment Focus,
Journal Year:
2023,
Volume and Issue:
7(3), P. 287 - 294
Published: Dec. 1, 2023
A
compelling
series
of
innovative
benzohydrazide
derivatives
has
been
successfully
synthesized
via
a
facile
condensation
reaction,
involving
the
strategic
union
with
diverse
substituted
formyl
pyrazole
under
reflux
conditions.
The
structural
elucidation
newly
formed
compounds
was
meticulously
accomplished
through
battery
spectroscopic
techniques,
including
FT-IR,
NMR
(
1
H
&
13
C),
and
mass
spectrometry,
ensuring
confirmation
their
molecular
integrity.
This
synthetic
approach
not
only
provides
robust
method
for
obtaining
versatile
array
but
also
holds
promise
biological
activities.
incorporation
both
moieties
renders
these
candidates
extensive
pharmacological
investigations.
flexibility
to
introduce
substituents
onto
phenyl
rings
presents
an
exciting
avenue
tailoring
properties
specific
applications.
Notably,
6b,
6c,
6d
demonstrated
remarkable
antibacterial
antifungal
activities
against
tested
microorganisms,
establishing
potential
as
potent
antimicrobial
agents.
Beyond
efficacy,
diversity
positions
them
valuable
entities
medicinal
chemistry
research,
offering
avenues
development
novel
pharmaceutical
present
study
underscores
significance
in
realm
chemistry,
hinting
at
catalyze
advancements
therapeutic
agent
development.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(10), P. 5098 - 5105
Published: Feb. 27, 2024
As
a
serious
public
health
issue,
malaria
threatens
the
of
millions
people.
Artemisinin,
gift
from
traditional
Chinese
medicine,
has
been
used
in
treatment
and
shown
good
therapeutic
efficiency.
However,
due
to
its
low
solubility,
poor
bioavailability,
short
half-life
time,
some
smart
delivery
strategies
are
still
required.
Herein,
multifunctional
DES
prepared
ibuprofen
menthol
was
prepared.
This
efficiently
promote
solubility
artemisinin
up
400-fold.
Then,
it
further
applied
as
oil
phase
construct
an
O/W
microemulsion
with
help
Tween-80
+
Span-20
mixed
surfactants.
The
displayed
high
efficiency
improving
permeability
artemisinin,
which
can
be
ascribed
presence
permeation
enhancer
microstructure
microemulsion.
Moreover,
simultaneous
indicated
potential
benefits
presented
formulation
malaria.
To
sum
up,
based
on
herein
provided
effective
method
for
transdermal
artemisinin.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 12, 2024
Biomaterials
are
substances
that
can
be
injected,
implanted,
or
applied
to
the
surface
of
tissues
in
biomedical
applications
and
have
ability
interact
with
biological
systems
initiate
therapeutic
responses.
Biomaterial-based
vaccine
delivery
possess
robust
packaging
capabilities,
enabling
sustained
localized
drug
release
at
target
site.
Throughout
process,
they
contribute
protecting,
stabilizing,
guiding
immunogen
while
also
serving
as
adjuvants
enhance
efficacy.
In
this
article,
we
provide
a
comprehensive
review
contributions
biomaterials
advancement
development.
We
begin
by
categorizing
biomaterial
types
properties,
detailing
their
reprocessing
strategies,
exploring
several
common
systems,
such
polymeric
nanoparticles,
lipid
hydrogels,
microneedles.
Additionally,
investigated
how
physicochemical
properties
routes
influence
immune
Notably,
delve
into
design
considerations
adjuvants,
showcasing
application
development
for
cancer,
acquired
immunodeficiency
syndrome,
influenza,
corona
virus
disease
2019
(COVID-19),
tuberculosis,
malaria,
hepatitis
B.
review,
highlight
successful
instances
where
enhanced
efficacy
discuss
limitations
future
directions
immunotherapy.
This
aims
offer
researchers
understanding
stimulate
further
progress
related
fields.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Abstract
Magnesium
Nanoparticles
(MgNPs),
are
biocompatible
and
have
shown
promise
in
various
biomedical
applications,
including
antimicrobial
antimalarial
treatments.
Synthesis
of
magnesium
nanoparticles
from
crude
extract
isolated
compound
crinum
jagus
rhizome
their
activity
were
reported.
mediated
by
characterized
UV-visible
spectroscopy,
SEM
TEM
analyses.
The
absorption
results
the
synthesized
showed
that
varies
slightly
across
wavelength
range
343
nm
to
353
nm,
with
a
peak
value
1.52934
at
345
nm.
data
for
(lupeol)
shows
significant
values
relatively
high,
where
absorbance
is
0.88005.
MgNPs
exhibited
best
(IC50
=
0.1310),
significantly
outperforming
both
lupeol-based
0.9103)
chloroquine
0.2762).
enhanced
extract-based
may
be
attributed
synergistic
effects
multiple
bioactive
compounds
present
extract.
observed
this
study
highlights
potential
combining
traditional
plant-based
medicine
nanotechnology.
lower
IC50
(0.1310)
compared
(0.2762)
demonstrate
promising
future
approach
overcoming
drug
resistance
improving
efficacy
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 24, 2025
Background
Plasmodium
vivax
is
a
major
cause
of
malaria,
particularly
outside
Africa,
necessitating
effective
strategies
for
public
health
management.
Transmission-blocking
vaccines
(TBVs)
have
shown
the
potential
to
inhibit
malaria
transmission
by
targeting
antigens
expressed
in
sexual-stage
parasites.
Pbg37,
conserved
protein
sexual
stages
from
gametocyte
ookinete
rodent
parasite
P.
berghei
,
viable
target
TBV
development.
Methods
and
findings
In
this
study,
we
constructed
transgenic
strain,
TrPvg37Pb
expressing
Pvg37
using
ΔPbg37
strain.
Initial
demonstrated
that
replacement
Pbg37
with
exogenous
did
not
impact
growth
or
Notably,
was
during
development
associated
plasmic
membrane,
similar
Pbg37.
To
evaluate
as
candidate,
synthesized
two
polypeptides
immunized
rabbits
generate
antibodies.
vitro
experiments
anti-Pvg37-P2
antibodies
significantly
inhibited
formation
male
gametes
ookinetes
parasite.
Additionally,
mosquito
feeding
assays,
mosquitos
on
-infected
mice
passively
transferred
showed
significant
80.2%
decrease
oocyst
density
compared
control
group.
Furthermore,
direct
membrane
four
clinical
isolates,
anti-Pvg37
reduced
28.6–50.4%.
Conclusion
promising
candidate
development,
deserving
further
research
optimization
enhance
its
immunogenicity
transmission-blocking
activity.
Biochemistry,
Journal Year:
2024,
Volume and Issue:
63(14), P. 1738 - 1751
Published: July 8, 2024
Over
the
past
two
decades,
utilization
of
protein
cages
has
witnessed
exponential
growth
driven
by
their
extensive
applications
in
biotechnology
and
therapeutics.
In
context
recent
Covid-19
pandemic,
protein-cage-based
scaffolds
played
a
pivotal
role
vaccine
development.
Beyond
vaccines,
these
have
proven
valuable
diverse
drug
delivery
thanks
to
distinctive
architecture
structural
stability.
Among
various
types
cages,
ferritin-based
taken
lead
applications.
This
is
primarily
attributed
ease
production,
exceptional
thermal
stability,
nontoxic
nature.
While
are
commonly
employed
anticancer
contrast
agent
delivery,
efficacy
malarial
had
not
been
explored
until
this
study.
investigation,
several
antimalarial
drugs
were
encapsulated
within
horse
spleen
ferritin,
binding
loading
processes
validated
through
both
experimental
computational
techniques.
The
data
unequivocally
demonstrate
facile
incorporation
into
ferritin
without
disrupting
its
three-dimensional
structure.
Computational
docking
molecular
dynamics
simulations
pinpoint
precise
location
site
ferritin.
Subsequent
testing
on
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 9, 2024
Malaria
is
one
of
the
most
devastating
diseases
across
globe,
particularly
in
low-income
countries
Sub-Saharan
Africa.
The
increasing
incidence
malaria
morbidity
mainly
due
to
shortcomings
preventative
measures
such
as
lack
vaccines
and
inappropriate
control
over
parasite
vector.
Additionally,
high
mortality
rates
arise
from
therapeutic
failures
poor
patient
adherence
drug
resistance
development.
Although
causative
pathogen
(
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(13), P. 5636 - 5648
Published: Jan. 1, 2024
Bis-thiosemicarbazones
with
strong
antiplasmodial
properties
are
found
to
exert
their
therapeutic
effects
through
Fe(
iii
)-selective
chelation
and
inhibition
of
hemozoin
formation
in
plasmodium
parasites.
A
significant
amount
of
effective
medicine
can
be
found
in
phytochemicals
thatare
natural
products
or
herb
extracts.
These
drugs
used
the
treatment
public
health
diseases
such
as
diabetes,
cardiovascular
disease,
malaria,
HIV,
COVID-19,
gastrointestinal
disorders,
neurodegenerative
diseases,
and
cancer.
There
are
therapeutic
limitations
when
phytomedicines
administered
conventional
pharmaceutical
dosage
forms
like
powders,tablets,
solutions,
brews,
balms.
include
low
aqueous
solubility,
poor
permeability,
degradation,
instability.
As
a
result,
there
is
production
yield,
absorption
bioavailability,
potency
efficacy,
toxicity
body.
not
they
could
be.
Polymeric
nanoparticles,
lipid
liposomes,
sterosomes,
metallic
nanoparticles
novel
drug
delivery
systems
that
circumvent
problems
systems.
nanocarriers
enhance
phytomedicine's
stability,
control,
prolong
release
herbal
medicine,
target
specific
sites
within
achieve
maximum
efficacy
with
significantly
fewer
adverse
effects.
The
use
phytopharmaceuticals
treatments
for
affect
extensively
covered
this
paper,
topic
nano-derived
phytopharmaceuticals.
