Drug Delivery and Translational Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
Abstract
Given
the
recurrent
waves
of
COVID-19
and
emergence
new
viral
infections,
optimizing
potential
remdesivir
as
an
antiviral
agent
is
critical.
While
several
reviews
have
explored
efficacy
remdesivir,
few
comprehensively
addressed
its
challenges,
such
necessity
for
intravenous
infusion,
suboptimal
lung
accumulation,
safety
concerns
related
to
formulation.
This
review
critically
examines
these
challenges
while
proposing
innovative
solutions
effective
combinations
with
other
agents
repurposed
drugs.
By
highlighting
role
complex
generics,
we
aim
enhance
therapeutic
in
ways
not
previously
discussed
existing
literature.
Furthermore,
address
development
novel
drug
delivery
systems
which
specifically
improve
remdesivir's
pharmacological
profile.
analyzing
recent
findings,
assess
both
successes
limitations
current
approaches,
providing
insights
into
ongoing
strategies
further
optimization.
uniquely
focuses
on
targeted
formulations,
thereby
maximizing
benefits
broadening
application
combating
emerging
threats.
In
doing
so,
fill
a
critical
gap
literature,
offering
comprehensive
overview
that
informs
future
research
clinical
strategies.
Graphical
Drug and Chemical Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: March 31, 2025
Surface
modifications
improve
the
properties
of
nanomaterials
and
make
them
more
appropriate
for
various
applications.
Various
materials
are
used
surface
modification
cerium
nanoparticles
(CeO2
NPs);
however,
there
is
no
process
with
glutamic
acid.
This
study
focused
on
preparation
L-glutamic
acid-coated
CeO2
NPs
reveal
its
potential
toxicity
depending
characteristic
properties.
Characterization
analysis
was
performed
by
Transmission
electron
microscopy
(TEM),
Fourier
transform
infrared
(FT-IR),
ZETA
sizer/potential
X-ray
diffraction
(XRD).
In
vitro
toxicities
Glu-CeO2
were
investigated
using
WST-1
(2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium,
monosodium
salt),
hemolysis
HET-CAM
(Hen's
egg-chorioallantoic
membrane)
tests.
Both
NPs-group
determined
to
be
non-
cytotoxic
L929
MCF-10A
cell
lines,
but
slightly
decrease
viability
A549
MCF-7
cells
after
24
exposure.
increased
migration
in
line
inhibited
cells.
contrast
NPs,
reduced
oxidative
stress
rate.
NP
caused
lysis
0.5nd
min,
while
didn't
exhibit
any
irritation
effect.
first
report
synthesis
NPs.
formulation
may
drug
delivery
systems
due
reduce
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 205 - 205
Published: Feb. 6, 2025
Cancer
represents
a
significant
societal,
public
health,
and
economic
challenge.
Conventional
chemotherapy
is
based
on
systemic
administration;
however,
it
has
current
limitations,
including
poor
bioavailability,
high-dose
requirements,
adverse
side
effects,
low
therapeutic
indices,
the
development
of
multiple
drug
resistance.
These
factors
underscore
need
for
innovative
strategies
to
enhance
delivery
directly
tumours.
However,
local
treatment
also
presents
challenges,
penetration
through
endothelial
layers,
tissue
density
in
tumour
microenvironment,
interstitial
fluid
pressure,
physiological
conditions
within
tumour,
permanence
at
site
action.
Nanotechnology
promising
alternative
addressing
these
challenges.
This
narrative
review
elucidates
potential
nanostructured
formulations
cancer
treatment,
providing
illustrative
examples
an
analysis
advantages
challenges
associated
with
this
approach.
Among
nanoformulations
developed
breast,
bladder,
colorectal,
oral,
melanoma
cancer,
polymeric
nanoparticles,
liposomes,
lipid
nanohydrogels
have
demonstrated
particular
efficacy.
systems
permit
mucoadhesion
enhanced
penetration,
thereby
increasing
concentration
(bioavailability)
consequently
improving
anti-tumour
efficacy
potentially
reducing
effects.
In
addition
studies
indicating
chemotherapy,
nanocarriers
can
be
used
as
theranostic
approach
combination
irradiation
methods.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 962 - 962
Published: Feb. 19, 2025
Cardiovascular
diseases
(CVDs)
represent
a
leading
global
health
crisis,
significantly
impairing
patients'
quality
of
life
and
posing
substantial
risks
to
their
survival.
Conventional
therapies
for
CVDs
often
grapple
with
challenges
such
as
inadequate
targeting
precision,
suboptimal
therapeutic
efficacy,
potential
adverse
side
effects.
To
address
these
shortcomings,
researchers
are
intensively
developing
advanced
drug
delivery
systems
characterized
by
high
specificity
selectivity,
excellent
biodegradability,
superior
biocompatibility,
minimal
toxicity.
These
innovative
enable
the
precise
pharmaceuticals
drug-loading
capacities,
leakage,
expansive
specific
surface
areas,
thereby
enhancing
outcomes.
In
this
review,
we
summarize
classify
various
materials
application
values.
We
also
evaluate
feasibility
efficacy
viral
non-viral
vectors
treatment
CVDs,
existing
limitations
prospects
discussed.
hope
that
review
will
provide
new
perspectives
future
development
ultimately
contributing
improved
patient
care
