Aberrances of the Wound Healing Process: A Review DOI Creative Commons
M. Fernández‐Guarino, Jorge Naharro‐Rodríguez, Stefano Bacci

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 209 - 209

Published: Nov. 28, 2024

Wound healing is a complex biological process that can lead to chronic wounds, keloids, and hypertrophic scars when disrupted. Chronic wounds result from prolonged inflammatory phase impaired re-epithelialization. Keloids are characterized by excessive collagen deposition beyond the original wound boundaries, driven persistent inflammation fibroblast hyperactivity. Hypertrophic scars, on other hand, confined edges caused an imbalance in synthesis degradation, typically resolving over time. The therapeutic approach impairment involves range of strategies, including non-invasive (which focus supporting natural process), minimally invasive, aggressive interventions (such as surgical approach, often reserved for severe or refractory cases). Emerging therapies, stem cell treatments botulinum toxin injections, offer new hope improving outcomes patients with impairments. This review highlights distinct mechanisms underlying discusses their respective approaches, focusing both established emerging therapies. Understanding these crucial optimizing treatment strategies patient outcomes.

Language: Английский

Avanços, Desafios E Estratégias Em Terapias De Feridas: Abordagens Conservadoras, Tecnológicas E Biopoliméricas DOI Creative Commons
Pedro Henrique Moura Teixeira,

Veronice Quieli Cavalheiro Barbosa,

Fillipe Eduardo Amorim Mesquita

et al.

Published: Jan. 14, 2025

Wound treatment represents a significant clinical challenge, requiring strategies that combine traditional approaches and technological innovations. The article analyzes advances in vacuum dressings, biopolymers nanotechnology-based materials, promoting faster more effective healing. research used an integrative literature review with databases such as PubMed, Scopus ScienceDirect, covering publications between 2019 2024. results highlight the use of Despite this, challenges remain, personalizing treatments adapting to different needs. combination methods emerging technologies has potential optimize care, accelerate tissue regeneration improve patients' quality life. study concludes integrated multidisciplinary approaches, combined new developments, are essential overcome barriers complex wounds.

Language: Английский

Citations

0
A Comprehensive Review on Stimuli-Responsive Nanomaterials: Advancements in Wound Healing and Tissue Regeneration DOI

M. Bellarmin,

J. Nandhini,

Karthikeyan Elumalai

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

0
A novel multifunctional self-assembled nanocellulose based scaffold for the healing of diabetic wounds DOI

Guangrui Ma,

Lina Fu, Hao Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123643 - 123643

Published: April 1, 2025

Language: Английский

Citations

0
Role of Biomaterials in Promoting Wound Healing DOI
Saeedeh Zare Jalise, Mohsen Sheykhhasan

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 367 - 412

Published: April 25, 2025

Because biomaterials can improve tissue repair and regeneration, their use in wound healing has drawn much attention. Biomaterials facilitate cellular connections, create favorable microenvironments, offer mechanical support, making them vital for promoting healing. These materials fall into three categories: natural, synthetic, hybrid. Natural polymers such as collagen, alginate, chitosan mimic the extracellular matrix biocompatibility, while synthetic like PLGA provide adjustable qualities strength degradation rates. Advanced hydrogels, nanoparticles, electrospun fibers enhance moisture retention, control drug release, reduce infection. They release bioactive chemicals growth factors antimicrobial peptides, preventing chronic wounds. This chapter examines various used healing, therapeutic uses, modes of action, well future developments challenges design, scalability.

Language: Английский

Citations

0
Advancements in chitosan-based nanocomposites with ZIF-8 nanoparticles: multifunctional platforms for wound healing applications DOI
Mojtaba Tarin, Mahsa Akbari Oryani, Hossein Javid

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123656 - 123656

Published: April 1, 2025

Language: Английский

Citations

0
Remote-Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model DOI Open Access
Houpu Li, Narges Asefifeyzabadi,

Kaelan Schorger

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Abstract Wound healing presents a significant challenge in biomedical science, requiring precise therapeutic delivery and real-time monitoring. Bioelectronic systems offer promising solution but remain largely unexplored for wound care, particularly large animal models that reflect human dynamics. This study introduces remote controlled wireless bioelectronic platform equipped with an iontophoretic pump to deliver fluoxetine, selective serotonin reuptake inhibitor promotes repair. In vitro ex-vivo testing validated efficient on demand fluoxetine delivery. vivo experiments porcine model demonstrated clear efficacy over 3-day 7-day periods. The system enhanced outcomes, increasing re-epithelialization by 37% (H&E staining), reducing the M1/M2 macrophage ratio 33%, stimulating neuronal growth at site. delivers controlled, remotely-controlled manner while allowing direct imaging can be used monitor progress. Additionally, it allows dose temporal of treatment enhance outcome future studies.

Language: Английский

Citations

1
Aberrances of the Wound Healing Process: A Review DOI Creative Commons
M. Fernández‐Guarino, Jorge Naharro‐Rodríguez, Stefano Bacci

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 209 - 209

Published: Nov. 28, 2024

Wound healing is a complex biological process that can lead to chronic wounds, keloids, and hypertrophic scars when disrupted. Chronic wounds result from prolonged inflammatory phase impaired re-epithelialization. Keloids are characterized by excessive collagen deposition beyond the original wound boundaries, driven persistent inflammation fibroblast hyperactivity. Hypertrophic scars, on other hand, confined edges caused an imbalance in synthesis degradation, typically resolving over time. The therapeutic approach impairment involves range of strategies, including non-invasive (which focus supporting natural process), minimally invasive, aggressive interventions (such as surgical approach, often reserved for severe or refractory cases). Emerging therapies, stem cell treatments botulinum toxin injections, offer new hope improving outcomes patients with impairments. This review highlights distinct mechanisms underlying discusses their respective approaches, focusing both established emerging therapies. Understanding these crucial optimizing treatment strategies patient outcomes.

Language: Английский

Citations

0