Abstract
Poly(lactic‐
co
‐glycolic
acid)
(PLGA)
nanoparticles
(NPs)
are
commonly
used
for
drug
delivery
because
of
their
favored
biocompatibility
and
suitability
sustained
controlled
release.
To
prolong
NP
circulation
time,
enable
target‐specific
overcome
physiological
barriers,
NPs
camouflaged
in
cell
membranes
have
been
developed
evaluated
to
improve
delivery.
Here,
we
discuss
recent
advances
membrane‐coated
PLGA
NPs,
preparation
methods,
application
cancer
therapy,
management
inflammation,
treatment
cardiovascular
disease
control
infection.
We
address
the
current
challenges
highlight
future
research
directions
needed
effective
use
membrane‐camouflaged
NPs.
Journal of Hematology & Oncology,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: May 14, 2021
Abstract
Long
known
as
digestive
organelles,
lysosomes
have
now
emerged
multifaceted
centers
responsible
for
degradation,
nutrient
sensing,
and
immunity.
Growing
evidence
also
implicates
role
of
lysosome-related
mechanisms
in
pathologic
process.
In
this
review,
we
discuss
physiological
function
and,
more
importantly,
how
the
homeostasis
is
disrupted
several
diseases,
including
atherosclerosis,
neurodegenerative
autoimmune
disorders,
pancreatitis,
lysosomal
storage
malignant
tumors.
atherosclerosis
Gaucher
disease,
dysfunction
changes
cytokine
secretion
from
macrophages,
partially
through
inflammasome
activation.
defect
autophagy
facilitates
accumulation
toxic
protein
dysfunctional
organelles
leading
to
neuron
death.
Lysosomal
has
been
demonstrated
pathology
pancreatitis.
Abnormal
activation
or
inhibition
revealed
disorders.
tumor
microenvironment,
phenotypes,
tumorigenesis,
growth
regulation,
invasion,
drug
resistance,
radiotherapy
cells
behaviors
tumor-associated
fibroblasts,
dendritic
cells,
T
are
mediated
by
lysosomes.
Based
on
these
findings,
a
series
therapeutic
methods
targeting
proteins
processes
developed
bench
bedside.
word,
present
researches
corroborate
be
pivotal
understanding
tumors
developing
novel
strategies.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Nov. 19, 2020
Cancer
disease
describes
any
pathology
involving
uncontrolled
cell
growth.
As
cells
duplicate,
they
can
remain
localized
in
defined
tissues,
forming
tumor
masses
and
altering
their
microenvironmental
niche,
or
disseminate
throughout
the
body
a
metastatic
process
affecting
multiple
tissues
organs.
tumors
grow
metastasize,
affect
normal
tissue
integrity
homeostasis
which
signals
to
trigger
acute
phase
inflammatory
response.
C-reactive
protein
(CRP)
is
predominant
of
response;
its
blood
levels
have
long
been
used
as
minimally
invasive
index
ongoing
response,
including
that
occurring
cancer.
Its
diagnostic
significance
assessing
progression
remission,
however,
remains
undefined.
By
considering
recent
understanding
CRP
exists
isoforms
with
distinct
biological
activities,
unified
model
advanced
relevance
mediator
host
defense
responses
monomeric,
modified
isoform
(mCRP)
modulates
by
inserting
into
activated
membranes
stimulating
platelet
leukocyte
associated
It
also
binds
components
extracellular
matrix
involved
tissues.
Conversely,
pentameric
(pCRP),
form
quantified
measurements
CRP,
notably
less
bioactive
weak
anti-inflammatory
bioactivity.
accumulation
continuous,
low-level
response
indicative
unresolved
advancing
disease,
occurs
Herein,
novel
interpretation
utility
presented
accounting
for
unique
properties
context
developing
pro-metastatic
microenvironment.
Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(9), P. 1086 - 1086
Published: Aug. 26, 2021
Curcumin
is
a
polyphenol
extracted
from
the
rhizomes
of
turmeric
plant,
Curcuma
longa
which
has
anti-inflammatory,
and
anticancer
properties.
Chronic
inflammation
associated
with
development
cancer.
acts
on
regulation
various
immune
modulators,
including
cytokines,
cyclooxygenase-2
(COX-2),
reactive
oxygen
species
(ROS),
partly
explains
its
effects.
It
also
takes
part
in
downregulation
growth
factors,
protein
kinases,
oncogenic
molecules
signaling
pathways,
such
as
nuclear
factor
kappa-light-chain-enhancer
activated
B
cells
(NF-κB),
c-Jun
N-terminal
kinase
(JNK)
signal
transducer
activator
transcription
3
(STAT3)
signaling.
Clinical
trials
curcumin
have
been
completed
or
are
ongoing
for
types
This
review
presents
molecular
mechanisms
different
cancer
evidence
most
recent
clinical
trials.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2019,
Volume and Issue:
15(4), P. 416 - 448
Published: Sept. 26, 2019
Conventional
tumor-targeted
drug
delivery
systems
(DDSs)
face
challenges,
such
as
unsatisfied
systemic
circulation,
low
targeting
efficiency,
poor
tumoral
penetration,
and
uncontrolled
release.
Recently,
tumor
cellular
molecules-triggered
DDSs
have
aroused
great
interests
in
addressing
dilemmas.
With
the
introduction
of
several
additional
functionalities,
properties
these
smart
including
size,
surface
charge
ligand
exposure
can
response
to
different
microenvironments
for
a
more
efficient
targeting,
eventually
achieve
desired
release
an
optimized
therapeutic
efficiency.
This
review
highlights
recent
research
progresses
on
environment
responsive
targeted
delivery.
Dynamic
strategies
functional
moieties
sensitive
variety
stimuli,
pH,
glutathione,
adenosine-triphosphate,
reactive
oxygen
species,
enzyme
inflammatory
factors
are
summarized.
Special
emphasis
this
is
placed
their
mechanisms,
loading
models,
drawbacks
merits.
Several
typical
multi-stimuli
listed.
And
main
challenges
potential
future
development
discussed.
Trends in cancer,
Journal Year:
2020,
Volume and Issue:
6(2), P. 86 - 97
Published: Jan. 18, 2020
Microbiota
have
emerged
as
key
modulators
of
both
the
carcinogenic
process
and
immune
response
against
cancer
cells,
and,
thus,
it
seems
to
influence
efficacy
immunotherapy.
While
most
studies
focused
on
analyzing
gut
microbiota,
its
composition
substantially
differs
from
that
in
lung.
Here,
we
describe
how
microbial
life
lungs
is
associated
with
host
status
identification
populations
lower
respiratory
tract
rather
than
might
be
understanding
lung
predict
different
treatments.
Understanding
microbiota
immunity
may
identify
new
therapeutic
targets
help
design
immunotherapy
approaches
treat
cancer.
Seminars in Cancer Biology,
Journal Year:
2021,
Volume and Issue:
86, P. 633 - 642
Published: Nov. 4, 2021
Despite
decades
of
research,
cancer
continues
to
be
a
major
global
health
concern.
In
recent
years,
the
role
played
by
microorganisms
in
development
and
progression
has
come
under
increased
scrutiny.
The
aim
present
review
is
highlight
main
associations
between
members
human
oral
microbiota
various
cancers.
PubMed
database
was
searched
for
available
literature
outline
current
state
understanding
regarding
variety
Oral
squamous
cell
carcinoma
(OSCC)
associated
with
carriage
number
bacteria
(e.g.,
Porphyromonas
gingivalis,
Fusobacterium
nucleatum,
Streptococcus
sp.),
certain
viruses
papilloma
virus,
herpes
virus
8,
simplex
1
Epstein-Barr
virus)
yeast
(Candida
albicans).
Moreover,
are
cancers
esophagus,
stomach,
pancreas,
colon/rectum
lung.
Furthermore,
outlines
carcinogenic
mechanisms
underlying
presented
microbial
cancer.
Such
information
may
one
day
help
clinicians
diagnose
neoplastic
diseases
at
earlier
stages
prescribe
treatments
that
take
into
account
possible
nature
carcinogenesis.
Biomolecules,
Journal Year:
2019,
Volume and Issue:
9(11), P. 679 - 679
Published: Nov. 1, 2019
Cancer
is
a
heterogeneous
disease
and
one
of
the
major
issues
health
concern,
especially
for
public
system
globally.
Nature
source
anticancer
drugs
with
abundant
pool
diverse
chemicals
pharmacologically
active
compounds.
In
recent
decade,
some
natural
products
synthetic
analogs
have
been
investigated
cancer
treatment.
This
article
presents
utilization
as
antitumor
drugs.
