Personal exposure to polycyclic aromatic hydrocarbons-bound particulate matter during pregnancy and umbilical inflammation and oxidative stress DOI Creative Commons
Xuan Zhang, Jia Wang, Yan Wu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117896 - 117896

Published: Feb. 1, 2025

Exposure to polycyclic aromatic hydrocarbons (PAHs), particularly when bound fine particulate matter (PM2.5), is an emerging concern for adverse prenatal health outcomes. This study investigates the associations between exposure PAHs-bound PM2.5 and markers of inflammation oxidative stress in umbilical cord blood. We conducted a prospective 450 mother-infant pairs, assessing levels during pregnancy using personal air sampling. Inflammatory biomarkers, including TNF-α, IL-6, IL-8, TGF-β, Pro-oxidant Antioxidant Balance (PAB), were measured Multivariable linear regression was used examine individual PAHs these while mixture effects evaluated quantile g-computation Bayesian Kernel Machine Regression (BKMR) assess combined influence 15 PAH congeners. Our findings revealed significant specific increased PAB. Mixture analysis indicated that each one-quartile increase associated with 0.31 pg/mL (95 % CI: 0.05-0.60, p = 0.01), 1.26 0.43-2.08, < 26.02 2.98-49.07, 0.02) respectively. However, IL-6 PAB showed no associations. BKMR further confirmed dose-response relationship elevated inflammatory markers. These highlight potential risks PM2.5, emphasizing need research mitigate developmental effects.

Language: Английский

Personal exposure to polycyclic aromatic hydrocarbons-bound particulate matter during pregnancy and umbilical inflammation and oxidative stress DOI Creative Commons
Xuan Zhang, Jia Wang, Yan Wu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117896 - 117896

Published: Feb. 1, 2025

Exposure to polycyclic aromatic hydrocarbons (PAHs), particularly when bound fine particulate matter (PM2.5), is an emerging concern for adverse prenatal health outcomes. This study investigates the associations between exposure PAHs-bound PM2.5 and markers of inflammation oxidative stress in umbilical cord blood. We conducted a prospective 450 mother-infant pairs, assessing levels during pregnancy using personal air sampling. Inflammatory biomarkers, including TNF-α, IL-6, IL-8, TGF-β, Pro-oxidant Antioxidant Balance (PAB), were measured Multivariable linear regression was used examine individual PAHs these while mixture effects evaluated quantile g-computation Bayesian Kernel Machine Regression (BKMR) assess combined influence 15 PAH congeners. Our findings revealed significant specific increased PAB. Mixture analysis indicated that each one-quartile increase associated with 0.31 pg/mL (95 % CI: 0.05-0.60, p = 0.01), 1.26 0.43-2.08, < 26.02 2.98-49.07, 0.02) respectively. However, IL-6 PAB showed no associations. BKMR further confirmed dose-response relationship elevated inflammatory markers. These highlight potential risks PM2.5, emphasizing need research mitigate developmental effects.

Language: Английский

Citations

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