Biodegradable Polymers for Application as Robust Immunomodulatory Biomaterial Carrier Systems
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 16, 2025
Abstract
The
field
of
immunotherapeutics
is
rapidly
evolving
with
the
advent
cell
therapies,
complex
biologics,
and
a
host
other
compounds.
Polymeric
carriers
are
often
used
to
tune
safety
efficacy
profiles
these
novel
drugs.
Despite
their
prevalence
in
pre‐clinical
clinical
applications,
non‐degradable
materials
present
delivery
challenges
including
diffusion‐limited
release,
frustrated
phagocytosis,
limited
clearance.
In
contrast,
biodegradable
polymeric
systems
provide
safer
alternative
addition
displaying
advantageous
properties
for
immunotherapies.
this
review,
discussion
polymers
poly(lactic‐co‐glycolic
acid)
(PLGA),
poly(beta‐amino
esters)
(PBAEs),
acetalated
dextran
(Ace‐DEX),
chitosan,
alginate,
hyaluronic
acid
(HA)
as
immunomodulatory
biomaterial
suggest
that
variety
can
be
generate
tailored
formulations
different
therapeutic
payloads
disease
indications.
These
carrier
enhance
immunotherapies
via
tunable
degradation
rates,
enhanced
antigen‐presentation,
inherent
biomaterials,
among
mechanisms.
Polymers
formulated
applications
synthetic,
semi‐synthetic,
or
naturally
derived.
Therefore,
it
crucial
consider
environmental
impact
polymer
sources,
particle
fabrication
methods,
solvent
usage
sustainably
develop
effective
therapies
field.
Language: Английский
Transplacental transmission of mRNA injections confirmed: does this evidence by Hanna and colleagues support their proposition as a promising prenatal gene therapy?
Published: Aug. 25, 2024
A
recent
study
by
Hanna
and
collaborators
assessed
the
presence
of
COVID-19
mRNA
productsin
placenta
umbilical
cord
blood
following
maternal
“vaccination”
during
human
pregnancy.Their
analysis
2
pregnant
women
revealed
that
genetic
injections
was
detected
inboth
placentas.
Spike
protein
expression
confirmed
in
one
them.
Furthermore,the
engineered
mother,
wherethose
samples
were
available
for
analysis.
They
also
found
integrity
injected
varied
across
samples,
but
overall,
a
substantial
or
even
overwhelming
majority
consisted
non-integrous
species.
The
authors
provide
several
theoretical
reasons
they
believe
explain
their
experiential
observations.
Based
on
results
shifting
aim,
indicate
benefits
suggest
related
gene
therapies,
particularly
mRNA-based
treatments,
may
have
great
promise
as
prenatal
therapy.
This
article
analyses
findings
interpretations
identifies
gaps
inconsistencies
explanations.
It
provides
short
synopsis
update
known
problems
with
outlines
major
pitfalls
unknowns
underlying
thepromised
intended
therapy
applications.
Language: Английский