Viruses, Journal Year: 2024, Volume and Issue: 16(10), P. 1547 - 1547
Published: Sept. 30, 2024
Crimean-Congo hemorrhagic fever virus (CCHFV) is an
Language: Английский
Acta Tropica, Journal Year: 2025, Volume and Issue: unknown, P. 107524 - 107524
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 16, 2025
Crimean-Congo haemorrhagic fever virus (CCHFV) poses a significant public health threat due to its potential for causing severe disease in humans and wide geographic distribution. The virus, primarily transmitted by Hyalomma ticks, is prevalent across Africa, Asia, Europe, the Middle East. Understanding virus's spread among tick populations crucial assessing transmission dynamics. Vertebrates play key role CCHF epidemiology supporting acting as carriers during viremia. Livestock, such cattle, sheep, goats, amplify increase numbers, posing zoonotic risks. Wildlife, while asymptomatic, can serve reservoirs. Birds generally do not show signs of but introduce infected ticks new regions. This review compiles information on CCHFV's vectors vertebrate hosts, emphasizing their roles these dynamics essential developing effective control prevention strategies.
Language: Английский
Citations
0
Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 387 - 387
Published: March 8, 2025
Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease prevalent in Africa. While infection asymptomatic animals, it can cause severe illness with manifestations and high mortality rates humans. This study aimed to determine the seroprevalence potential risk factors of CCHF wild (rodents, birds) domestic (cattle, horses) animals Benin. A cross-sectional was carried out from 2022 2024 assistance cattle breeders, hunters, farmers bushmeat sellers 15 districts found three agroecological zones country. total 366 serum samples were analyzed, comprising 254 collected 112 animals. Among tested, 1.18% (95% CI: 0.31–3.70; n = 3) seropositive for antibodies against virus (CCHFV). The 3.7% 0.19–20.89) squirrels, 5.88% 0.31–30.76) hares 1.19% 0.06–7.38) giant rats. In anti-CCHFV detected 38 samples, resulting an overall 33.93% 25.42–43.56). Specifically, identified 34 81 (41.98%, 95% 31.26–53.46) 4 24 horses (16.67%, 5.48–38.19). No positive reported pigeons. provides first data on It highlights epidemiological dynamics underscores need further investigations into tick vectors human populations.
Language: Английский
Citations
0
Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 291 - 291
Published: March 10, 2025
Background/Objectives: Crimean–Congo hemorrhagic fever virus (CCHFV) is an emerging, widely distributed zoonotic tick-borne pathogen. The causes severe disease in humans, and numerous wild domestic animals act as reservoirs of it. Unfortunately, there are no effective therapies or safe vaccines commercialized nowadays for this particular virus. As CCHF (Crimean–Congo fever) a serious threat to public health, urgent need investigate the development vaccination strategies further. Methods: In work, we have employed two immunization platforms based on protein nanoparticles modified vaccinia Ankara (MVA) viral vector using nucleoprotein (NP) target antigen. humoral cellular immune responses were characterized by ELISA, ICS, cytokine measurement. Results: This work shows that single dose vaccine candidates was not immunogenic heterologous MVA. A prime with NP (NS-NP) boost MVA-expressing capable triggering significant levels against CCHFV mice. Conclusions: Our study NS-NP/MVA-NP strategy effectively elicits robust response mouse model, emphasizing its potential protective approach lineages.
Language: Английский
Citations
0
Infectious Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100177 - 100177
Published: March 1, 2025
Language: Английский
Citations
0
CABI Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Abstract Mycoplasma bovis infections in cattle constitute a worldwide problem with significant detrimental economic impacts on industry. Mastitis, pneumonia, arthritis, keratoconjunctivitis, otitis media and genital disorders are its clinical manifestations. Presently, no vaccines commercially available; antimicrobial resistance is increasing; diagnostic sensitivity testing needs to be improved; new rapid diagnosis kits eminent for implementation of treatment antimicrobials. We conducted systematic search databases such as PubMed, Scopus, Web Science, Google Scholar, AGRIS African Journals Online (AJOL), from 1995 2024. Searched keywords, as, bovis, M : vaccine development, techniques strain variability using the predefined criteria were used address review objectives. Although they have preventative function, – killed, live attenuated, subunit types face difficulties because M. strains vary widely. Every approach has own set benefits drawbacks, those that been studies include conventional culture identification, serological testing, immunohistochemical demonstration tissues, sophisticated molecular like PCR, qPCR, next-generation sequencing. For early detection, successful treatment, vaccination efficacy monitoring, accurate crucial. Future directions managing -associated diseases improving accessibility creating broad-spectrum vaccinations. By incorporating these developments, it may possible enhance health cattle, promote sustainability livestock production, increase food security. This points urgent need further research innovation advancement support
Language: Английский
Citations
0
Viruses, Journal Year: 2024, Volume and Issue: 16(10), P. 1547 - 1547
Published: Sept. 30, 2024
Crimean-Congo hemorrhagic fever virus (CCHFV) is an
Language: Английский
Citations
0