Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 113, P. 107242 - 107242

Published: Jan. 22, 2025

In the context of molecular imaging, present work explores an innovative platform made lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, dynamics gas bubbles generation cavitation under insonation with either pristine or (ZnO-Lip) are described, differences between two colloidal systems highlighted. These ZnO-Lip show unprecedented ability to assist cavitation, which is reflected in enhanced sonoluminescent light emission respect pure water. Highly defined sharp images cultured cells indeed obtained, first time, when used. Furthermore, were adopted a nanosized i.e. echography, solutions, then on ex-vivo tissues. A prolonged over time bright effect observed adopting developed nanoparticles. their nanometric size potential targeting biomolecules would allow ease extravasation tissue even cell penetration, achieving enhanced-contrast imaging. Finally, stimuli-responsive therapeutic applications against tumors overviewed, aiming achieve fully theranostic approach.

Language: Английский

In vitro methodologies to evaluate nanocarriers for cancer treatment: where are we?

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 17, 2025

Language: Английский