The expanding structural variety among bacteriocins from Gram-positive bacteria

FEMS Microbiology Reviews, Journal Year: 2018, Volume and Issue: 42(6), P. 805 - 828

Published: July 31, 2018

Bacteria use various strategies to compete in an ecological niche, including the production of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has been postulated that majority Gram-positive bacteria produce one or more these natural products. can be used food preservation also considered as potential alternatives antibiotics. The bacteriocins from had traditionally divided into two major classes, namely lantibiotics, which post-translationally modified bacteriocins, unmodified last decade seen expanding number peptides (RiPPs) have activity. These include linear azol(in)e-containing thiopeptides, bottromycins, glycocins, lasso lipolanthines. In addition, three-dimensional (3D) structures a elucidated recent years. This review gives overview on structural variety bacteria. It will focus chemical 3D their interactions with receptors membranes, structure–function relationships possible modes action.

Language: Английский

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Bacillusspp.as direct-fed microbial antibiotic alternatives to enhance growth, immunity, and gut health in poultry

Avian Pathology, Journal Year: 2018, Volume and Issue: 47(4), P. 339 - 351

Published: April 11, 2018

The increasing occurrence of antibiotic-resistant bacteria combined with regulatory pressure and consumer demands for foods produced without antibiotics has caused the agricultural industry to restrict its practice using antibiotic growth promoters (AGP) in food animals. poultry is not immune this trend, been actively seeking natural alternatives AGP that will improve health performance commercial flocks. Bacillus probiotics have gaining popularity recent years as an alternative because their health-promoting benefits ability survive harsh manufacturing conditions chicken feed production. This review provides overview several modes action some direct-fed microbials probiotics. Among these are production naturally synthesized antimicrobial peptides, gut flora modulation promote beneficial microbiota along gastrointestinal tract, various immunological morphological alterations. increased well defined, promotion equal across all species or within strains. Appropriate screening characterization isolates prior commercialization necessary maximize meet ultimate goal eliminating usage animal husbandry.

Language: Английский

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Secretome of Intestinal Bacilli: A Natural Guard against Pathologies

Frontiers in Microbiology, Journal Year: 2017, Volume and Issue: 8

Published: Sept. 1, 2017

Current studies of human gut microbiome usually do not consider the special functional role transient microbiota, although some its members remain in host for a long time and produce broad spectrum biologically active substances. Getting into gastrointestinal tract (GIT) with food, water probiotic preparations, two representatives Bacilli class, genera Bacillus Lactobacillus, colonize epithelium blurring boundaries between resident microbiota. Despite their minor proportion composition, these bacteria can significantly affect both intestinal microbiota entire body thanks to wide range secreted compounds. Recently, insufficiency limitations pure genome-based analysis became known. Thus, need intense is evident. This review aims characterize Lactobacillus GIT, as well roles components released by microbial community. Complex compounds referred us "bacillary secretome". The composition bacillary secretome, biological effects GIT counteraction infectious diseases oncological pathologies organism subject review.

Language: Английский

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Elicitors of Plant Immunity Triggered by Beneficial Bacteria

Frontiers in Plant Science, Journal Year: 2020, Volume and Issue: 11

Published: Nov. 9, 2020

The molecular basis of plant immunity triggered by microbial pathogens is being well characterized as a complex sequential process leading to the activation defense responses at infection site, but which may also be systemically expressed in all organs, phenomenon known systemic acquired resistance. Some plant-associated and beneficial bacteria are able stimulate their host mount defenses against pathogen ingress via phenotypically similar, induced resistance phenomenon. Induced resembles considering its mechanistic principle it successively involves recognition cell surface, stimulation early cellular immune-related events, signaling fine-tuned hormonal cross-talk mechanisms. It thus represents an indirect efficient mechanism with biocontrol potential improve capacity plants restrict invasion. However, according our current vision, specific some aspects underpinning these different steps. Here we overview chemical diversity compounds that have been identified elicitors thereby illustrating species responsive range from micro- mesofauna can controlled this We point out need for further investigations allowing better understanding how sensed nature stimulated

Language: Английский

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A look into a multifunctional toolbox: endophytic Bacillus species provide broad and underexploited benefits for plants

World Journal of Microbiology and Biotechnology, Journal Year: 2018, Volume and Issue: 34(7)

Published: June 13, 2018

Language: Английский

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Bacillus Responses to Plant-Associated Fungal and Bacterial Communities

Frontiers in Microbiology, Journal Year: 2020, Volume and Issue: 11

Published: June 23, 2020

Some members of root-associated Bacillus species have been developed as biocontrol agents due to their contribution plant protection by directly interfering with the growth pathogens or stimulating systemic resistance in host. As rhizosphere-dwelling bacteria, these bacilli are surrounded and constantly interacting other microbes via different types communications. With this review, we provide an updated vision molecular phenotypic responses upon sensing rhizosphere microorganisms and/or metabolites. We illustrate how spp. may react modulating production secondary metabolites, such cyclic lipopeptides polyketides. On hand, some developmental processes, biofilm formation, motility, sporulation also be modified interaction, reflecting adaptation multicellular communities microbial competitors for preserving ecological persistence. This review points out limited data available a global lack knowledge indicating that more research is needed order to, not only better understand ecology natural soil niche, but assess improve promising potential.

Language: Английский

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Breeding for soil-borne pathogen resistance impacts active rhizosphere microbiome of common bean

The ISME Journal, Journal Year: 2018, Volume and Issue: 12(12), P. 3038 - 3042

Published: July 17, 2018

Language: Английский

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Mining prokaryotes for antimicrobial compounds: from diversity to function

FEMS Microbiology Reviews, Journal Year: 2017, Volume and Issue: 41(3), P. 417 - 429

Published: March 2, 2017

The bacterial kingdom provides a major source of antimicrobials that can either be directly applied or used as scaffolds to further improve their functionality in the host. rapidly increasing amount genomic, metabolomic and transcriptomic data offers unique opportunities apply variety approaches mine for existing novel antimicrobials. Here, we discuss several powerful mining identify molecules with antimicrobial activity across structurally diverse natural products, including ribosomally synthesized posttranslationally modified peptides, nonribosomal peptides polyketides. We not only direct genomes based on identification biosynthetic gene clusters, but also describe more advanced integrative ecology-based mining, functionality-based mode-of-action-based mining. These efforts are likely accelerate discovery development drugs.

Language: Английский

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Prebiotic, Probiotic, Antimicrobial, and Functional Food Applications of Bacillus amyloliquefaciens

Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 68(50), P. 14709 - 14727

Published: Dec. 7, 2020

Bacillus amyloliquefaciens belongs to the genus and family Baciliaceae. It is ubiquitously found in food, plants, animals, soil, different environments. In this review, application of B. probiotic prebiotic microbes fermentation, synthesis, hydrolysis food compounds discussed as well further insights into its potential gaps. also a microbe synthesis bioactive including peptides exopolysaccharides. addition, it can synthesize antimicrobial (e.g., Fengycin, Bacillomycin Lb), which makes novelty sector greater. Moreover, imparts improves functional, sensory, shelf life end products. The complex insoluble proteins, carbohydrates, fibers, hemicellulose, lignans shows that multifunctional be applied industry functional processing.

Language: Английский

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Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: June 8, 2017

Abstract Lactobacilli constitute a large genus of Gram-positive lactic acid bacteria which have widespread roles ranging from gut commensals to starters in fermented foods. A combination silico and laboratory-based screening allowed us determine the overall bacteriocin producing potential representative strains each species genus. The genomes 175 lactobacilli 38 associated were screened for presence antimicrobial genes combined with activity against range indicators. There also appears be link between strains’ environment production, those animal human microbiota encoding over twice as many bacteriocins other sources. Five novel identified belonging differing classes, including two-peptide (muricidin acidocin X) circular (paracyclicin). In addition, there was clear clustering helveticin type bacteriolysins Lactobacillus acidophilus group species. This vitro approach has demonstrated true diversity complexity across It highlights their biological importance terms communication competition closely related diverse complex microbial environments.

Language: Английский

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