Inverse association between prognostic nutritional index and kidney stone prevalence: A population-based study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318254 - e0318254

Published: Feb. 18, 2025

Background Kidney stones frequently occur due to metabolic disorders, dietary habits, and lifestyle influences. The Prognostic Nutritional Index, which reflects an individual’s nutritional condition, might be associated with kidney stone prevalence. This study examines the association between PNI prevalence in US adults. Methods used data from National Health Nutrition Examination Survey database 2009–2018 excluded pregnant women, individuals who lacked on stones, or had incomplete Index data. Independent associations were investigated by multivariate logistic regression subgroup analyses, addition exploring nonlinear using smoothed curves threshold effects. Results A total of 13,835 participants aged ≥ 20 years included, a 8.48%. An inverse was observed (OR = 0.97, 95% CI 0.96–0.98, P < 0.001). relationship not significantly modified race, education, marital status, comorbidities such as hypertension, diabetes, hyperlipidemia. However, sex cholesterol levels influenced association. Stratified analysis showed significant negative men 0.98, 0.96–0.99, 0.031), but women. identified 5.2 mmol/L, below inflection point 57 0.96, 0.012) positive above it 1.11, 0.03). These findings suggest that is inversely particularly those high levels. Conclusion negatively risk point, suggesting tailored management may crucial for these subgroups.

Language: Английский

Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study

BMJ Open Ophthalmology, Journal Year: 2025, Volume and Issue: 10(1), P. e001902 - e001902

Published: April 1, 2025

Glaucoma is a complex neurodegenerative ocular disorder accompanied by brain functional abnormalities that extend beyond the visual system. However, causal association between two remains unclear at present. This study aimed to investigate potential relationships glaucoma and networks in order provide novel insights into neuropathic mechanism of glaucoma. Based on genome-wide studies data resting-state MRI (Rs-fMRI), bidirectional Mendelian randomisation (MR) analysis was conducted networks. Inverse variance weighting applied as primary method estimate causality with false discovery rate correction. Additional sensitivity analyses were evaluate robustness results. Forward MR suggested causally associated subcortical cerebellum attention or network (p=0.022), well default mode central executive (p=0.008), but without significance after correction (q>0.1). Reverse revealed 19 Rs-fMRI traits related risk, including salience frontal region (p=0.0005, q=0.08) motor (p=0.0009, significant causality. potentially Especially, connectivity postcentral precentral areas may lead increased risk

Language: Английский