The microbiome extends host evolutionary potential

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Aug. 26, 2021

Abstract The microbiome shapes many host traits, yet the biology of microbiomes challenges traditional evolutionary models. Here, we illustrate how integrating into quantitative genetics can help untangle complexities host-microbiome evolution. We describe two general ways in which may affect potential: by shifting mean phenotype and changing variance population. synthesize literature across diverse taxa discuss these scenarios could shape response to selection. conclude outlining key avenues research improve our understanding complex interplay between hosts microbiomes.

Language: Английский

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Artificial Selection on Microbiomes To Breed Microbiomes That Confer Salt Tolerance to Plants

mSystems, Journal Year: 2021, Volume and Issue: 6(6)

Published: Nov. 30, 2021

We develop a method to artificially select for rhizosphere microbiomes that confer salt tolerance the model grass Brachypodium distachyon grown under sodium stress or aluminum stress. In controlled greenhouse environment, we differentially propagated between plants of nonevolving, highly inbred plant population; therefore, only evolved in our experiment, but did not evolve parallel. To maximize microbiome perpetuation when transplanting and, thus, response selection, improved earlier methods by (i) controlling assembly inoculating seeds at beginning each selection cycle; (ii) fractionating before transfer harvest, perpetuate, and on bacterial viral components; (iii) ramping gradually from minor extreme with cycle minimize chance overstressing plants; (iv) using two nonselection control treatments (e.g., microbial enrichment null inoculation) permit comparison improving fitness benefits selected impart plants. Unlike previous methods, protocol generated enhance after 1 3 rounds selection. After nine effect was nonspecific (these equally ameliorate stresses), specific do stress). Plants had 55 205% greater seed production than unselected microbiomes. IMPORTANCE developed an experimental improves artificial then tested efficacy breed root-associated plant. Salt limits growth crop plants, conferring may ultimately help improve agricultural productivity. experiments productivity microbiomes, increasing Although conditions differ outdoor conditions, is remarkable enhancement compared traditional breeding. describe series additional protocols will advance insights into key parameters determine

Language: Английский

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Microbiome breeding: conceptual and practical issues

Trends in Microbiology, Journal Year: 2022, Volume and Issue: 30(10), P. 997 - 1011

Published: May 18, 2022

Language: Английский

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Wolbachia impacts microbiome diversity and fitness‐associated traits for Drosophila melanogaster in a seasonally fluctuating environment

Ecology and Evolution, Journal Year: 2024, Volume and Issue: 14(7)

Published: July 1, 2024

Abstract The microbiome contributes to many different host traits, but its role in adaptation remains enigmatic. fitness benefits of the often depend on ecological conditions, theory suggests that fluctuations both and environment modulate these benefits. Moreover, vertically transmitted bacteria might constrain ability respond changing environments. Drosophila melanogaster provides an excellent system investigate impacts interactions between environment. To address this question, we created field mesocosms D. undergoing seasonal environmental change with without bacteria, Wolbachia pipientis . Sampling temporal patterns revealed constrained microbial diversity. Furthermore, a dominant member microbiome, Commensalibacter , were associated differences two higher‐order starvation resistance lifespan. Our work here interplay abiotic context microbe–microbe may shape key phenotypes underlie We conclude by exploring consequences complex for our understanding eco‐evolutionary processes host‐microbiome interactions.

Language: Английский

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Microbial solutions to dietary stress: experimental evolution reveals host–microbiome interplay in Drosophila melanogaster

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2043)

Published: March 1, 2025

Can the microbiome serve as a reservoir of adaptive potential for hosts? To address this question, we leveraged approximately 150 generations experimental evolution in Drosophila melanogaster on stressful, high-sugar diet. We performed fully reciprocal transplant experiment using control and bacteria. If confers benefits to hosts, then recipients should gain fitness compared with controls. Interestingly, found that such exist, but their magnitude depends evolutionary history—mismatches between fly reduced fecundity potentially exerted costs, especially stressful The dominant bacteria ( Acetobacter pasteurianus ) uniquely encoded several genes enable uric acid degradation, mediating toxic effects accumulation due diet flies. Our study demonstrates host genotype × environment interactions have substantial phenotype, highlighting how ecological context together shape microbiome.

Language: Английский

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Dietary Trends, Microbiome, and Cardiovascular Health: A Narrative Review

Heart and Mind, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Cardiovascular (CV) disease (CVD) remains a leading cause of morbidity and mortality worldwide, with growing evidence highlighting the role diet gut microbiome in cardiovascular health (CVH). This review synthesizes current knowledge on interactions between dietary patterns, microbiome, CV outcomes. High-fiber diets, such as Mediterranean Dietary Approaches to Stop Hypertension, promote beneficial microbial species, enhancing production short-chain fatty acids that exhibit anti-inflammatory cardioprotective effects. Conversely, Western diets high fat low fiber are associated dysbiosis elevated trimethylamine-N-oxide (TMAO) levels, metabolite linked increased atherosclerosis CVD risk. TMAO has been shown amplify systemic inflammation by upregulating pro-inflammatory cytokines, interleukin-6 tumor necrosis factor-alpha, exacerbating damage. explores how composition influences metabolic immune functions, contributing endothelial dysfunction, which critical progression. Personalized nutrition, informed profiling, represents promising avenue for optimizing CVH. Emerging therapeutic strategies, including probiotics, prebiotics, fecal microbiota transplantation, also offer potential modulating improve

Language: Английский

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Vector microbiota and immunity: modulating arthropod susceptibility to vertebrate pathogens

Current Opinion in Insect Science, Journal Year: 2022, Volume and Issue: 50, P. 100875 - 100875

Published: Jan. 19, 2022

Language: Английский

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Evolutionary implications of host genetic control for engineering beneficial microbiomes

Current Opinion in Systems Biology, Journal Year: 2023, Volume and Issue: 34, P. 100455 - 100455

Published: April 27, 2023

Engineering new functions in the microbiome requires understanding how host genetic control and microbe-microbe interactions shape microbiome. One key mechanism underlying is immune system. The system can promote stability composition of by reshaping ecological dynamics its members, but degree will depend on interplay between context, development, higher-order interactions. eco-evolutionary affecting should inform strategies used to engineer We conclude with recent methodological developments that provide an important path forward for both engineering functionality broadly evolutionary processes complex biological systems.

Language: Английский

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Shedding light on bacteria associated with an agricultural pest, the tropical plant bug *Monalonion velezangeli*: a foundational descriptive study

Peer Community In Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 4, 2024

A recommendation of: Lucio Navarro-Escalante, Pablo Benavides, Flor Edith Acevedo Diversity of bacterial symbionts associated with the tropical plant bug Monalonion velezangeli (Hemiptera: Miridae) revealed by high-throughput 16S-rRNA sequencing https://doi.org/10.21203/rs.3.rs-2022560/v7

Language: Английский

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Diversity of bacterial symbionts associated with the tropical plant bug Monalonion velezangeli (Hemiptera: Miridae) revealed by high-throughput 16S-rRNA sequencing

Peer Community Journal, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 29, 2024

Insects and microbes have developed complex symbiotic relationships that evolutionarily ecologically play beneficial roles for both, the symbiont host. In most Hemiptera insects, bacterial symbionts offer mainly nutritional, defensive, reproductive in addition to promoting adaptive radiation of several hemipteran phytophagous lineages. The tropical plant bug Monalonion velezangeli (Hemiptera: Miridae) is a polyphagous herbivore considered an important insect pest economically relevant crops, but information about composition its microbiota was missing. this study, we describe diversity structure nymph adult life stages M. using Illumina high-throughput sequencing 16S ribosomal RNA gene amplicons (meta-barcoding). We found both share similar terms community structure. intracellular Wolbachia dominated overall microbiome (~92%) these stages. Members core include Wolbachia, Romboutsia, Ignavibacterium, Clostridium, Allobaculum, Paracoccus, Methylobacterium, Faecalibacterium, Collinsella, Rothia, Sphingomonas 4 other undetermined genera. Based on PCR screening DNA wsp gene, infection confirmed almost 80% samples, represented by two different isolates or strains within supergroup B. This data offers opportunities studying contribution bacteria biological performance pest, provides base explore control methods.

Language: Английский

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