The functional landscape of the appendix microbiome under conditions of health and disease DOI Creative Commons
Md Shahjalal Sagor, Tarequl Islam,

Noshin Tabassum Tamanna

et al.

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: June 1, 2025

Abstract Traditionally regarded as a vestigial organ, the appendix is now being reevaluated for its significant function in health and nutrition of humans. Serving “safe house” beneficial, desired gut bacteria, protected by resilient biofilms that create secure environment. This makes a”basin” microbiota (GM), replenishing microbial population following disruptions from infections, antibiotic use, or inflammatory bowel disease (IBD). Beyond simply hosting has an active role functions immune system. Disruption Appendix Microbiome (AM), such through appendectomy, was found to result lowered diversity microorganisms increased risk various diseases. The potential therapeutic applications AM are particularly promising area research. appendix’s unique environment impact on immunity open new avenues treatments. These include modulating GM improve cancer treatment outcomes, mitigating IBD, regulating metabolic pathways obesity diabetes, influencing neurotransmitter production neurological disorders, addressing cardiovascular autoimmune review highlights transformation misunderstood organ critical component immunity. It explores human reservoir microorganisms, progression. Furthermore, it examines AM, presenting exciting opportunities future research innovations.

Language: Английский

The functional landscape of the appendix microbiome under conditions of health and disease DOI Creative Commons
Md Shahjalal Sagor, Tarequl Islam,

Noshin Tabassum Tamanna

et al.

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: June 1, 2025

Abstract Traditionally regarded as a vestigial organ, the appendix is now being reevaluated for its significant function in health and nutrition of humans. Serving “safe house” beneficial, desired gut bacteria, protected by resilient biofilms that create secure environment. This makes a”basin” microbiota (GM), replenishing microbial population following disruptions from infections, antibiotic use, or inflammatory bowel disease (IBD). Beyond simply hosting has an active role functions immune system. Disruption Appendix Microbiome (AM), such through appendectomy, was found to result lowered diversity microorganisms increased risk various diseases. The potential therapeutic applications AM are particularly promising area research. appendix’s unique environment impact on immunity open new avenues treatments. These include modulating GM improve cancer treatment outcomes, mitigating IBD, regulating metabolic pathways obesity diabetes, influencing neurotransmitter production neurological disorders, addressing cardiovascular autoimmune review highlights transformation misunderstood organ critical component immunity. It explores human reservoir microorganisms, progression. Furthermore, it examines AM, presenting exciting opportunities future research innovations.

Language: Английский

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