Impact of a High-Fat Diet on the Gut Microbiome: A Comprehensive Study of Microbial and Metabolite Shifts During Obesity

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 463 - 463

Published: March 20, 2025

Over the last few decades, prevalence of metabolic diseases such as obesity, diabetes, non-alcoholic fatty liver disease, hypertension, and hyperuricemia has surged, primarily due to high-fat diet (HFD). The pathologies these show disease-specific alterations in composition function their gut microbiome. How HFD alters microbiome its metabolite mediate adipose tissue (AT) inflammation obesity is not well known. Thus, this study aimed identify changes metabolomic signatures induced by an alter obesity. To explore microbiota metabolites, 16S rRNA gene amplicon sequencing analyses were performed after normal (ND) feeding. We noticed that, at taxonomic levels, number operational units (OTUs), along with Chao Shannon indexes, significantly shifted HFD-fed mice compared those fed a ND. Similarly, phylum level, increase Firmicutes decrease Bacteroidetes mice. At genus Lactobacillus Ruminococcus was observed, while Allobaculum, Clostridium, Akkermansia markedly reduced group. Many bacteria from impair bile acid metabolism restrict weight loss. are efficient breaking down complex carbohydrates into short-chain acids (SCFAs) other whereas involved more balanced or energy extraction. over enhances absorption calories food, which may contribute Taken together, altered metabolites trigger AT inflammation, contributes dysregulation disease progression. highlights potential development therapeutic strategies for related disorders.

Language: Английский

Echinacoside alleviates type 2 diabetes mellitus through inhibiting hepatic gluconeogenesis via gut bacterial-fungal trans-kingdom network reconstruction

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156802 - 156802

Published: April 1, 2025

Language: Английский