Hemodynamic evaluation of endovascular techniques of stenting and coiling for the treatment of internal carotid artery aneurysm: a computational study DOI Creative Commons
Jian Pei, Xiang Xu,

Li-Cai Zhao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 24, 2024

The selection optimum endovascular method for the treatment of different cerebral aneurysms has been main challenge surgeons. In present article, computational technique is used hemodynamic evaluation two techniques stent and coiling reduction hemorrhage risk ICA aneurysms. Comprehensive analyses blood flow are performed to detect potential regions with high at critical stages cardiac cycle. Two porosity conditions deformation have investigated via study reveal change related hemodynamics when these implemented. results this show that more efficient in small rather than giant ones. Meanwhile, saccular aneurysm effective parent vessel type fully aligned limited enters sac area.

Language: Английский

The long-term and post-prandial effects of berry consumption on endothelial dysfunction in adults: a systematic review and meta-analysis of randomised controlled trials DOI

Shokoofeh Talebi,

Mahsa Shirani, Nafiseh Shokri Mashhadi

et al.

International Journal of Food Sciences and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: Jan. 19, 2025

This systematic review and meta-analysis evaluated the long-term post-prandial effects of berry consumption on endothelial dysfunction (ED) in adults. To identify relevant randomised controlled trials (RCTs), a search was run studies that examined berries ED markers were included. A total 45 RCTs included, focusing such as flow-mediated dilation (FMD), pulse wave velocity (PWV), augmentation index (AIx), reactive hyperaemia (RHI) peripheral resistance (TPR). The revealed significantly increased FMD decreased PWV. However, no significant found for AIx, RHI or TPR. In studies, also improved FMD, but had impact PWV, AIx RHI. Overall, to benefit function, particularly improving though other cardiovascular less consistent. Factors like trial design type influenced outcomes.

Language: Английский

Citations

1
5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation DOI Creative Commons
Jinque Luo, Xin Li, Li Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is a significant medical condition characterized severe pulmonary inflammation and tissue damage. NLRP3 inflammasome-driven essential in ALI pathogenesis, inspiring novel therapeutic strategies that focus on inflammation. In this study, we investigated the potential of 5-deoxy-rutaecarpine (5-DR), rutaecarpine derivative, attenuating LPS-induced ALI. evaluated effects 5-DR treatment mice exposed to LPS, tissues, bronchoalveolar lavage fluid, serum were collected for analysis. LPS-stimulated J774A.1 mouse macrophages used further investigate anti-inflammatory vitro. Various techniques including histopathology, Western blotting, luciferase reporter assay employed. significantly reduced edema, inflammatory cell infiltration with LPS burden, levels mediators like interleukin-1β macrophages. Further western blotting analysis showed decreased NLRP3, cleaved caspase-1, mature IL-1β cells LPS. Additionally, NF-κB pathway activation diminished inhibition inflammasome 5-DR. Our findings highlight as promising candidate treating ALI, offering insights into its underlying mechanism targets inflammasome-mediated

Language: Английский

Citations

0
The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer DOI
Ashok Kumar Balaraman, Muhammad Afzal, Ehssan Moglad

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 5, 2025

Language: Английский

Citations

0
Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas DOI Open Access
Tsai‐Der Chuang,

Nhu Ton,

Shawn Rysling

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1688 - 1688

Published: Feb. 16, 2025

We performed next-generation sequencing (NGS) on RNA from 19 paired leiomyoma (Lyo) and myometrium (Myo) specimens, stratified by race/ethnicity (White: n = 7; Black: 12) mediator complex subunit 12 (MED12) mutation status (mutated: 10; non-mutated: 9). Analysis identified 2,189 small non-coding RNAs (sncRNAs) with altered expression in Lyo compared to Myo (≥1.5-fold change), including nuclear (snRNAs), nucleolar (snoRNAs), microRNAs (miRNAs), PIWI-interacting (piRNAs). Among these, 17 sncRNAs showed differential the MED12-mutated group versus Myo, while minimal changes were observed non-mutated group. Additionally, 31 displayed Black women White women. For validation, five novel miRNAs (miR-19a-3p, miR-99a-5p, miR-3196, miR-499a-5p, miR-30d-3p) piRNAs (piR-009295, piR-020326, piR-020365, piR-006426, piR-020485) analyzed 51 samples using qRT-PCR. Reduced of selected was confirmed miR-19a-3p, miR-30d-3p, piR-020485 linked MED12 status, miR-499a-5p miR-30d-3p associated race/ethnicity. These findings suggest that sncRNA dysregulation contributes gene Lyo, influenced racial background.

Language: Английский

Citations

0
Effects of Exercise Body Conditions on Hemodynamics of Blood Flow in Saccular ICA Aneurysms: Pre- and Post-Stent-Induced Deformation DOI
Chunyu Ji, Bowen Wei

Chinese Journal of Physics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Electric double layer and thermal radiation effects on micropolar blood particles conveying Cu-MoS2-CuO nanoparticles in squeezed arterial channel DOI
Adebowale Martins Obalalu, Umair Khan, Mervat G. Hassan

et al.

Nuclear Engineering and Technology, Journal Year: 2025, Volume and Issue: 57(8), P. 103604 - 103604

Published: April 5, 2025

Language: Английский

Citations

0
Unraveling Disease-Associated PIWI-Interacting RNAs with a Contrastive Learning Methods DOI

Xiao-Wen Hu,

Hao Sun,

L.Y. Shan

et al.

Journal of Chemical Information and Modeling, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

PIWI-interacting RNAs (piRNAs) are a class of small, non-coding predominantly expressed in the germ cells animals and play crucial role maintaining genomic integrity, mediating transposon suppression, ensuring gene stability. Beyond their functions reproductive cells, piRNAs also roles various human diseases, including cancer, suggesting potential as significant biomarkers critical for disease diagnosis treatment. Wet-lab methods to identify piRNA-disease associations require substantial resources often hit-or-miss. With advancements computational technologies, an increasing number researchers employing efficiently predict associations. The sparsity data association studies significantly limits model performance improvement. In this study, we propose novel model, iPiDA_CL, through contrastive learning methods, which do not negative samples. represents pairs bipartite graph computes initial embeddings diseases using Gaussian kernel similarity, with features updated via LightGCN. Based on siamese network framework, iPiDA_CL constructs online target networks employs augmentation build objective that optimizes parameters without introducing Finally, cross-prediction used calculate specific scores. A series experimental results demonstrate surpasses state-of-the-art both efficiency. application miRNA-disease dataset underscores its versatility across ncRNA-disease task. Furthermore, case study highlights efficient promising tool predicting

Language: Английский

Citations

0
Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review) DOI Creative Commons
Lingling Wang, Xin Li,

Xiaoju Men

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 31(1)

Published: Nov. 7, 2024

Cataracts are primarily caused by aging or gene mutations and the leading cause of blindness globally. As older population increases, number patients with a cataract is expected to grow rapidly. At present, surgery replace lens an artificial intraocular principal treatment method. However, has several drawbacks, including economic burdens complications such as inflammation, xerophthalmia, macular edema posterior capsular opacification. Thus, developing effective non‑surgical strategy beneficial both public health. Mechanistically, formation may be due various reasons but initiated promoted oxidative stress closely associated crystallin aggregation. In present review, current research progress on anti‑cataract drugs, antioxidants protein aggregation inhibitors examined. It summarizes strategies for preventing treating through cell apoptosis inhibition while discussing their limitations further prospects. 

Language: Английский

Citations

0
Zinc‐Catalysed [3+2] Cycloaddition of Enaminone with Tosylhydrazide to Synthesise 1H‐pyrazole via C–N and S–N Bond Cleavage DOI
Sanjukta Roy, Rana Chatterjee, Rambabu Dandela

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract A novel and practical zinc‐catalysed synthesis of 1 H ‐pyrazole has been developed. The one‐pot protocol enables the cycloaddition enaminone tosylhydrazide via C−N S−N bond breaking process, leading to diverse mono‐substituted pyrazole derivatives in high yields. Moreover, easily accessible materials, broad substrate scope with excellent functional group tolerance, ease isolation open‐air conditions are key features present method.

Language: Английский

Citations

0
Hemodynamic evaluation of endovascular techniques of stenting and coiling for the treatment of internal carotid artery aneurysm: a computational study DOI Creative Commons
Jian Pei, Xiang Xu,

Li-Cai Zhao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 24, 2024

The selection optimum endovascular method for the treatment of different cerebral aneurysms has been main challenge surgeons. In present article, computational technique is used hemodynamic evaluation two techniques stent and coiling reduction hemorrhage risk ICA aneurysms. Comprehensive analyses blood flow are performed to detect potential regions with high at critical stages cardiac cycle. Two porosity conditions deformation have investigated via study reveal change related hemodynamics when these implemented. results this show that more efficient in small rather than giant ones. Meanwhile, saccular aneurysm effective parent vessel type fully aligned limited enters sac area.

Language: Английский

Citations

0