Prevalence and Factors Associated With Symptom Profiles of Disorders of Gut‐Brain Interaction in Obesity Before and After Treatment

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Disorders of gut-brain interaction (DGBI) in obesity could impair health outcomes. Therefore, we aimed to study the prevalence and burden symptoms compatible with a DGBI assess effect treatment on comorbid DGBI. We used baseline two-year follow-up data from prospective non-randomized cohort including patients referred for treatment. Patients completed Rome III questionnaire before after receiving Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or medical Validated questionnaires blood parameters were obesity. In total, 939 (73% female, 44 ± 13 years, 42 5 kg/m2, 36% treatment, 38% RYGB, 20% SG) at 651 (32 6 kg/m2) follow-up. The proportion symptom profile was reduced 61% (24% esophageal, 27% gastroduodenal, bowel, 8% anorectal disorders) 53% (15% 25% 34% There substantial shift between profiles across all GI regions. presented more severe psychological distress, poorer quality life, likely be female. are common can outcomes Obesity lowers general, but an important regions observed.

Language: Английский

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Disorders of the gut‐brain interaction among European people with obesity: Prevalence and burden of compatible symptoms

United European Gastroenterology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Introduction The prevalence of disorders the gut‐brain interaction (DGBI) among people with obesity in general population is unknown. Our aim was to assess DGBI obese subjects comparison normal or overweight subjects, as well exploring factors associated Europe. Methods We included who completed internet‐based survey Rome Foundation Global Epidemiology study 11 European countries. Obesity defined a BMI>30 kg/m 2 and participants were divided into three classes: 1: BMI 30 <35 , 2: 35 <40 3: 40 higher. symptoms compatible reported compared between (BMI 18.5 <30 ) participants. Factors potentially including demographics, psychological distress (PHQ‐4), non‐GI somatic (PHQ–12), quality life (PROMIS‐10), healthcare access, medication food consumption assessed. Results 20,117 our analysis. 17.8% (95% CI 17.3, 18.4), 12.6%, 3.7% 1.6% classes 1, 3, respectively. any 44.2% group versus 39.6% (OR = 1.20 (1.12, 1.30)), all being more prevalent group, exception for functional constipation where opposite pattern seen. Female sex, higher level severe seen obesity. Conclusions Symptoms are common linked certain demographic disease‐related factors. This should be acknowledged management patients

Language: Английский

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Nutritional knowledge, fiber intake, body mass index, and sex associated with constipation symptoms in Peruvian adults

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Language: Английский

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Association between body roundness index and constipation using data from NHANES 2005–2010

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 17, 2025

Obesity, particularly visceral fat, is a well-established risk factor for various gastrointestinal disorders, including constipation, possibly due to its metabolic and hormonal effects on bowel motility, though the mechanisms remain unclear. The Body Roundness Index (BRI), novel reliable anthropometric measure, has been validated as precise indicator of fat. However, relationship with constipation remains uncertain. This population-based, cross-sectional study analyzed data from 6,898 participants in National Health Nutrition Examination Survey (NHANES, 2005-2010) assess this association. Binary logistic regression analyses, adjusted multiple covariates, revealed that higher BRI levels were significantly associated lower likelihood constipation. Participants highest quartile had 32% odds than those lowest (adjusted OR: 0.68; 95% CI: 0.54-0.86; P: 0.0013). As was study, findings indicate an association between rather causality. These results suggest could be practical accessible marker identifying individuals different susceptibility potentially aiding clinical assessment guiding preventive strategies.

Language: Английский

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Negative association between body roundness index and constipation: insights from NHANES

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 9, 2025

The relationship between body roundness index (BRI), a metric that distinguishes heterogeneity in fat distribution, and constipation is unclear. This study the first to investigate association BRI based on National Health Nutrition Examination Survey (NHANES) United States, providing new perspective mechanisms of obesity-related gastrointestinal dysfunction. cross-sectional utilized data from NHANES conducted 2005 2010. Constipation was diagnosed Bristol Stool Form Scale (BSFS). Weighted logistic regression models were employed assess prevalence. Restricted cubic splines (RCS) piecewise linear applied evaluate non-linear relationships constipation. Propensity score matching (PSM) implemented match constipated non-constipated populations with similar baseline characteristics. Subsequent analyses correlation A total 12,732 eligible participants included. negative observed prevalence, an adjusted odds ratio (OR) 0.87 (95% CI: 0.80, 0.95) after controlling for all covariates. When categorized into quartiles (Q1-Q4), both Q3 Q4 groups exhibited significantly reduced risk compared Q1 (OR = 0.72, 95% 0.54-0.97; OR 0.63, 0.46-0.87). RCS model revealed inverse (nonlinearity test P 0.083). Subgroup identified significant interaction effects age, alcohol consumption status, hypertension (interaction < 0.05). Post PSM, patients demonstrated higher levels than non-constipation counterparts (P 0.013). An U.S. adults, suggesting lower may correlate raised incidence. underscores critical importance maintaining optimal prevention. Further research warranted elucidate underlying governing this association.

Language: Английский

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Association between non-high-density lipoprotein to high-density lipoprotein cholesterol ratio and bowel health in U.S. adults: a cross-sectional study

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) is a robust predictor of dyslipidemia and cardiovascular disease, strongly linked the development various chronic conditions. However, there paucity evidence exploring relationship between NHHR bowel health, particularly diarrhea constipation. This cross-sectional study utilized data from National Health Nutrition Survey (NHANES) 2005-2010. Sociodemographic, lifestyle, health status were collected alongside blood lipid levels. Weighted multivariate logistic regression models assessed association health. restricted cubic spline (RCS) method was used explore their dose-response relationship. Subgroup analyses sensitivity conducted further validate robustness our findings. In 11,268 participants, significant positive identified elevated levels constipation in women, with highest quartile showing an adjusted OR 1.57 (95% CI: 1.21-2.03) compared lowest quartile. notably stronger among female smokers. Sensitivity excluding individuals hypercholesterolemia or inflammatory disease confirmed correlation. No associations found men. findings provide novel United States design limits ability establish causality. Additionally, reliance on self-reported may introduce inaccuracies. Further research needed mechanisms underlying this impact lifestyle factors.

Language: Английский

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Effects of <i>Bifidobacterium longum</i> CLA8013 on bowel movement improvement: a placebo-controlled, randomized, double-blind study

Bioscience of Microbiota Food and Health, Journal Year: 2023, Volume and Issue: 42(3), P. 213 - 221

Published: Jan. 1, 2023

A placebo-controlled, randomized, double-blind study was conducted to evaluate the effect of taking 25 billion colony-forming units heat-killed Bifidobacterium longum CLA8013 over 2 weeks on bowel movements in constipation-prone healthy individuals. The primary endpoint change defecation frequency between baseline and after intake B. CLA8013. secondary endpoints were number days defecation, stool volume, consistency, straining during pain feeling incomplete evacuation abdominal bloating, fecal water content, Japanese version Patient Assessment Constipation Quality Life. total 120 individuals assigned two groups, 104 (control group, n=51; treatment n=53) whom included analysis. After consuming CLA8013, increased significantly group compared with that control group. Furthermore, showed a significant increase volume improvement defecation. No adverse events attributable observed period. This revealed improved confirmed there no relevant safety issues.

Language: Английский

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Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome

Nutrients, Journal Year: 2021, Volume and Issue: 13(7), P. 2138 - 2138

Published: June 22, 2021

The association between vitamin D deficiency and metabolic syndrome (MS) in severe obesity is unclear controversial. We analyzed serum dietary their with MS 150 adults class II III (BMI ≥ 35 kg/m2) from the DieTBra Trial (NCT02463435). parameters were high fasting blood glucose, low HDL cholesterol, triglycerides, elevated waist circumference, hypertension. Vitamin was considered as a level < 20 ng/mL. performed multivariate Poisson regression adjusted for sociodemographic lifestyle variables. prevalence of 13.3% (mean 29.9 ± 9.4 ng/mL) median 51.3 IU/day. There no significant associations D, serum, diet variables, lifestyle, obesity. Serum associated age 50 years (p = 0.034). After fully regression, its not or except lower HDL, which (PR 0.71, 95% CI 0.52-0.97; p 0.029). Severe obese individuals had deficiency, MS.

Language: Английский

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LimosiLactobacillus pentosus Isolated from Mustard Relieves Drug-induced Constipation in Mice Fed a High-fat Diet by Modulating Enteric Neurotransmitter Function

Probiotics and Antimicrobial Proteins, Journal Year: 2022, Volume and Issue: 15(5), P. 1371 - 1381

Published: Sept. 9, 2022

Language: Английский

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Association of normal weight obesity with lifestyle and dietary habits in young Thai women: A cross-sectional study

Obesity Pillars, Journal Year: 2023, Volume and Issue: 5, P. 100055 - 100055

Published: Jan. 26, 2023

The risk of lifestyle-related diseases in normal weight obesity (NWO), a condition, which the body mass index (BMI) is but fat high, has attracted lot attention. However, there are no reports on association between NWO and lifestyle, eating habits, other health risks Thai people. BMI alone cannot be used to identify individuals with NWO; thus, some students develop metabolic abnormalities without receiving any intervention. This study aimed examine differences anthropometrics, habits among young women their ratio (BFR).A total 250 female university type (18.5 ≤ BMI<25.0 kg/m2) were classified as having non-normal (NO-NWO) if BFR was <30.0% or >30.0%. lifestyle two groups compared. We conducted logistic analysis presence absence dependent variable, dietary habit items "eating greasy foods," ultra-processed foods (UPF)," "drinking sweetened beverages" objective variables.Among participants who type, 46.8% NWO. group consumed UPF more frequently (odds [OR], 2.04; p = 0.014) beverages regularly (OR, 1.92, 0.041) than those NO-NWO group.UPF beverage consumption common Identifying factors for essential help make changes prevent its progression complications.

Language: Английский

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