PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(4), P. e0301129 - e0301129
Published: April 1, 2024
Background
The
impact
of
per-
and
polyfluoroalkyl
substances
(PFAS)
on
constipation,
as
mediated
through
gastrointestinal
absorption
perturbations
to
the
intestinal
microecology,
remains
poorly
understood.
Objective
This
study
seeks
explain
relationship
between
PFAS
constipation.
Methods
A
total
2945
adults
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2010
were
included
in
this
study.
Constipation
was
defined
using
Bristol
Stool
Form
Scale
(BSFS)
based
stool
consistency.
constipation
evaluated
weighted
logistic
regression
restricted
cubic
spline
(RCS)
analysis,
while
adjusting
for
confounding
variables.
Results
median
concentration
(ΣPFAS)
significantly
lower
individuals
with
(19.01
μg/L)
compared
those
without
(23.30
(p
<
0.0001).
Subgroup
analysis
revealed
that
cumulative
effect
more
pronounced
elderly,
men,
obesity,
high
school
education
or
equivalent,
high-income
0.05).
After
factors,
multivariable
demonstrated
an
inverse
association
PFOA
[OR
(95%
CI),
0.666(0.486,0.914)]
PFHxS
0.699(0.482,1.015)],
None
personal
lifestyle
factors
showed
a
significant
correlation
negative
association,
confirmed
by
subgroup
interaction
testing
>
RCS
linear
levels
Conclusion
findings
provide
evidence
serum
concentrations
PFAS,
particularly
PFHxS,
BioMed Research International,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 9
Published: June 21, 2022
Background.
Constipation
is
a
common
digestive
disorder
in
the
elderly
population,
which
has
considerable
impact
on
various
aspects
of
their
lives.
Traditional
and
complementary
medicines
are
two
treatments
for
constipation.
This
study
was
aimed
at
comparing
effects
abdominal
massage
oral
administration
sweet
almond
oil
constipation
quality
life
among
people.
Methods.
In
this
single-blind
study,
90
eligible
people
were
randomly
selected
according
to
ROME
IV
diagnostic
criteria
from
October
2020
May
2021
divided
into
three
groups
using
block
randomization
(
).
consumption
group,
126
ml
administered
during
seven
sessions
held
over
weeks
(18
every
other
day).
The
group
provided
with
same
amount
weeks.
Finally,
third
(i.e.,
control
group)
received
no
interventions.
measured
Assessment
Scale
(CAS)
Bristol
Stool
Form
(BSFS)
baseline
15th
day
intervention.
Patient
Constipation-Quality
Life
(PAC-QOL)
also
applied
before
after
intervention
(day
15).
data
entered
SPSS
22
software
analyzed
chi-square
id="M2">
t
-test,
paired
id="M3">
independent
id="M4">
ANOVA.
id="M5">
p≤0.05
considered
statistically
significant.
Results.
results
revealed
significant
decrease
CAS
score
oil;
id="M6">
7.81±2.62
id="M7">
1.151.08
,
id="M8">
<0.0003
)
compared
massage;
id="M9">
82.57
id="M10">
2.261.81
id="M11">
0.0002
(from
id="M12">
7.732.53
id="M13">
62.74
id="M14">
Additionally,
stool
consistency
BSFS
significantly
higher
comparison
id="M15">
Furthermore,
decreased
more
id="M16">
75.047.66
id="M17">
28.153.30
id="M18">
than
id="M19">
81.155.15
id="M20">
43.264.13
id="M21">
0.0001
id="M22">
79.624.76
id="M23">
62.316.40
id="M24">
0.0008
Conclusion.
Since
highly
influential
participants’
scores
life,
these
cost-effective
methods
low
complication
rates
recommended
be
used
alongside
managing
older
adults.
Diseases of the Colon & Rectum,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 2, 2023
BACKGROUND:
Constipation
and
fecal
incontinence
have
a
negative
influence
on
quality
of
life.
The
association
between
the
severity
problems
life
has
not
been
investigated
in
non-patient
population.
OBJECTIVE:
To
investigate
constipation
non-patients.
DESIGN:
A
population-based,
cross-sectional
study.
SETTINGS:
study
involved
3668
Dutch
PATIENTS:
survey
company
conducted
population-wide
general
Altogether,
5000
citizens
completed
Groningen
Defecation
Fecal
Continence
Short-Form
36
questionnaires.
data
respondents
without
comorbidities
that
could
bowel
function
were
included
for
analysis.
MAIN
OUTCOME
MEASURES:
(Agachan
score)
(Wexner
relation
to
quality-of-life
scores.
RESULTS:
In
population
(n
=
3668),
487
(13.3%)
had
constipation,
116
(3.2%)
incontinence,
two
coexisted
64
(1.7%).
multivariable
analysis,
all
domains
negatively
associated
with
incontinence.
associations
stronger
(highest:
ß
-2.413,
95%
CI,
-2.681
-2.145,
p
<
0.001)
than
those
-1.280,
-1.681
-.880,
0.001).
We
also
found
longer
duration
complaints
coincided
higher
scores,
especially
constipation.
Mostly,
rated
their
defecation
health
as
positive,
regardless
problems.
LIMITATIONS:
Cross-sectional
design.
CONCLUSIONS:
is
significantly
reduced
life,
having
Given
respondents'
unawareness
progressive
character
thereof,
timely
intervention
advocated.
The Heart Surgery Forum,
Journal Year:
2024,
Volume and Issue:
27(1), P. E038 - E047
Published: Jan. 18, 2024
Background:
The
aim
of
this
study
was
to
estimate
the
potential
influencing
factors
postoperative
constipation
in
patients
undergoing
cardiovascular
surgery.
Methods:
This
included
a
cohort
379
who
underwent
surgery
at
Nanjing
Drum
Tower
Hospital.
patient
stratified
into
two
groups
based
on
presence
or
absence
constipation.
Utilizing
logistic
regression
analysis,
both
univariate
and
multivariate
analyses
were
conducted
elucidate
defecation
problems.
predictive
accuracy
findings
subsequently
evaluated
through
receiver
operating
characteristic
(ROC)
curve.
Results:
Among
subjected
surgery,
noteworthy
20.8%
(n
=
79)
reported
incidences
issues.
A
analysis
showed
that
age
(odds
ratio
(OR)
1.063,
95%
confidence
interval
(CI)
1.034–1.097,
p
<
0.001),
operation
time
(OR
1.004,
CI:
1.000–1.008,
0.028),
ventilator
usage
1.032,
1.010–1.055,
0.004),
polypharmacy
2.134,
1.069–4.321,
0.032),
use
cough
medicine
2.981,
1.271–6.942,
0.011)
psychological
behavioral
barriers
hospital
environment
31.039,
14.313–73.179,
0.001)
independent
risk
for
area
under
curve
(AUC)
predicting
0.885.
Conclusion:
In
pursuit
optimizing
recovery
mitigating
incidence,
targeted
approach
is
imperative.
Specifically,
focused
intervention
directed
towards
elderly
patients,
extended
prolonged
durations,
regimens,
medicine,
those
with
within
milieu
emerges
as
pivotal.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(4), P. e0301129 - e0301129
Published: April 1, 2024
Background
The
impact
of
per-
and
polyfluoroalkyl
substances
(PFAS)
on
constipation,
as
mediated
through
gastrointestinal
absorption
perturbations
to
the
intestinal
microecology,
remains
poorly
understood.
Objective
This
study
seeks
explain
relationship
between
PFAS
constipation.
Methods
A
total
2945
adults
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2010
were
included
in
this
study.
Constipation
was
defined
using
Bristol
Stool
Form
Scale
(BSFS)
based
stool
consistency.
constipation
evaluated
weighted
logistic
regression
restricted
cubic
spline
(RCS)
analysis,
while
adjusting
for
confounding
variables.
Results
median
concentration
(ΣPFAS)
significantly
lower
individuals
with
(19.01
μg/L)
compared
those
without
(23.30
(p
<
0.0001).
Subgroup
analysis
revealed
that
cumulative
effect
more
pronounced
elderly,
men,
obesity,
high
school
education
or
equivalent,
high-income
0.05).
After
factors,
multivariable
demonstrated
an
inverse
association
PFOA
[OR
(95%
CI),
0.666(0.486,0.914)]
PFHxS
0.699(0.482,1.015)],
None
personal
lifestyle
factors
showed
a
significant
correlation
negative
association,
confirmed
by
subgroup
interaction
testing
>
RCS
linear
levels
Conclusion
findings
provide
evidence
serum
concentrations
PFAS,
particularly
PFHxS,
