Factors that influence recruitment to COVID-19 vaccine trials: a qualitative evidence synthesis

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 19, 2024

The COVID-19 pandemic marked a unique period characterised by an extraordinary global virus spread. collective effort to halt the transmission of led various public health initiatives, including variety vaccine trials. Many these trials used adaptive methods address pandemic's challenges, such as need for rapid recruitment. These allow modifications trial procedures without undermining trial's integrity, making research process more flexible and efficient. However, recruiting participants remains considerable challenge. aim this qualitative evidence synthesis (QES) is explore factors that influence person's decision participate in trial. Lessons learned from could help shape future trials' design conduct, particularly those conducted within pandemic. We systematic search studies mixed with component WHO Research Database, MEDLINE, CINAHL, PsycINFO, Epistemomikos, Online Resource Clinical Trials (ORCCA), Cochrane Study Register. best-fit framework approach Social Ecological Model priori framework. GRADE-CERQual assess our confidence review findings. Five involving 539 were included. One included In three studies, asked hypothetically about their attitudes. Another study people who had either not responded or declined invitation developed six themes outlining trial: (1) personal gains, (2) perceived risk, (3) family community, (4) contributing others, (5) institutional trust mistrust, (6) accessibility This sheds light on how perceive potential personal, family, community advantages participation perceptions may be weighed against concerns safety. findings also point toward specific aspects methodology consider when designing

Language: Английский

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Analysis of the Effectiveness of Measures on the COVID-19 Vaccination Rate in Hong Kong

Vaccines, Journal Year: 2022, Volume and Issue: 10(5), P. 747 - 747

Published: May 10, 2022

Background: The World Health Organization has set a target of at least 70% the global population being vaccinated by middle 2022. There are only 17 countries that achieved vaccination rate (VR). This study aims to analyze effectiveness public policies increase COVID-19 VR. Methods: figures all eligible groups in Hong Kong from 22 February 2021 23 January 2022, were extracted for analysis. Weekly acceleration VR (AVR) was calculated as measure policy effectiveness. A total 13 identified measures classified into four categories: eligibility, accessibility, incentives, and restrictions. Age-weighted AVR (AWAVR) compared age group presence vs. absence using Mann−Whitney U tests. Results: AWAVR means across ranged −1.26% +0.23% (p = 0.12) eligibility; accessibility +0.18% +1.51% < 0.0001); incentives +0.11% +0.68% restrictions +0.02% +1.25% 0.0001). Conclusions: targeting effective increasing These results may serve reference.

Language: Английский

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Safety and immunogenicity of MVC-COV1901 vaccine in older adults: Phase 2 randomized dose-comparison trial

International Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 124, P. 21 - 26

Published: Aug. 29, 2022

IntroductionOlder adults are subject to higher COVID-19 infection and mortality rates. Safety immunogenicity of MVC-COV1901, a protein subunit vaccine have been demonstrated in phase 2 clinical trial for the general population, negative correlations observed between immune responses age, however, older were under-represented.MethodsA double-blind, randomized, multi-center study compared safety high-dose (25 mcg) mid-dose (15 MVC-COV1901 administered times 28 days apart 420 participants 65 years older. The results stratified by comorbidity status.ResultsBoth high regimens elicited mostly mild adverse events robust when measured as neutralizing binding antibodies titers. High doses better group without comorbidities.ConclusionGiven population-associated we recommend dose immunization elder with MVC-COV1901. was registered at https://clinicaltrials.gov/ (NCT04822025).

Language: Английский

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Supporting and inhibiting factors of accepting COVID-19 booster vaccination in the elderly in north Jakarta, Indonesia

Pharmacy Practice, Journal Year: 2022, Volume and Issue: 20(4), P. 01 - 09

Published: Dec. 1, 2022

The risk of fatal infection and death from Coronavirus disease 2019 (COVID-19) exposure increases in the elderly those with coexisting illnesses such as cardiovascular disease, diabetes, cancer, obesity, hypertension. COVID-19 vaccine's efficacy safety have been supported by numerous research. However, data Ministry Health Indonesia revealed that North Jakarta had a reclining interest receiving booster dose. This research aimed to assess perception living related supporting inhibiting factors accepting vaccination.This qualitative used grounded theory design. It was conducted March May 2022, were gathered Jakarta's districts through in-depth interviews until saturation reached. Furthermore, validated using member checking, source triangulation families elderly, vaccination doctors. They processed produce transcripts, codes, finalized themes.Booster 12 out 15 informants, rest did not agree. include health, family, peer support, doctors, government, administrative requirements, endemic transformation, choice, media coverage. Meanwhile, hoaxes, concerns over efficacy, political issues, comorbidities.Most displayed positive attitudes concerning shots, but it discovered some barriers need be removed.

Language: Английский

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COVID-19 vaccine acceptance and related behavioral and psychological characteristics in individuals with mental disorders in Korea

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 16, 2023

This study aimed to investigate COVID-19 vaccine acceptance and related factors in individuals with mental disorders Korea.We surveyed 572 about their attitudes toward vaccination using a 7-item self-rating questionnaire on hesitancy. We categorized the respondents into groups based level of hierarchical clustering. In addition, we evaluated respondents' status trust sources information regarding vaccines, assessed psychological characteristics Patient Health Questionnaire-9, Gratitude Questionnaire-6, Big Five Inventory-10.Clustering revealed three according acceptance: 'totally accepting' (n= 246, 43.0%), 'somewhat 184, 32.2%), 'hesitant' 142, 24.8%) groups. Three quarters all participants, who belonged or groups, were willing receive despite concerns its side effects. Individuals high group older (F= 12.52, p< 0.001), more likely influenza regularly, formal sources. Additionally, they had higher levels gratitude 21.00, 0.001) agreeableness 4.50, p= 0.011), lower depression (χ2= 11.81, 0.003) neuroticism 3.71, 0.025).The present demonstrated that generally vaccination. However, weighed need effectiveness against potential effects before coming decision. It is important understand behavioral associated acceptance, effectively communicate importance disorders.

Language: Английский

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