(1)
Background:
Since
the
onset
of
SARS-CoV-2
pandemic,
seven
epidemic
waves
have
been
described
in
Spain.
Our
objective
was
to
study
mortality
and
severity,
associated
factors
our
hospitalized
patients;
(2)
Method:
Retrospective
cohort
conducted
on
COVID-19
patients
admitted
Hospital
de
Fuenlabrada
(Madrid,
Spain)
from
beginning
pandemic
until
December
31,
2022;
(3)
Results:
A
total
5,510
admissions
for
were
recorded.
First
wave
accounted
1,823
(33%)
exhibited
highest
proportion
severe
(lowest
mean
oxygen
saturation,
88.2%;
elevated
levels
CRP,
IL-6,
D-dimer
ferri-tin),
but
a
below-average
percentage
intubated
(5%
vs.
6.5%).
Overall
rate
10.3%,
higher
during
first
(11.5%)
two
winter
(third:
11.3%,
sixth:
12%),
although
represented
39%
total.
Variables
with
age
(OR
1.08,1.07-1.09),
need
high-flow
6.10,4.94-7.52),
oncological
disease
1.88,1.53-2.60),
dementia
1.82,1.2-2.75),
Charlson
index
1.38,1.31-1.47),
maxi-mum
IL-6
1.001,1.000-1.001);
(4)
Conclusions:
in-cluded
age,
comorbidity,
respiratory
failure,
inflammation.
Differences
baseline
charac-teristics
explained
differences
each
International Journal of Infectious Diseases,
Journal Year:
2023,
Volume and Issue:
132, P. 84 - 88
Published: April 22, 2023
COVID-19
was
severe
in
the
Delta
variant-dominated
epidemic
wave
(fifth
wave)
Japan.
The
clinical
characteristics
and
effectiveness
of
vaccination
are
not
fully
understood
Omicron
(sixth
seventh
waves),
especially
hospitalized
patients.
We
investigated
relationship
between
disease
severity
Omicron-dominated
compared
these
waves.The
nationwide
database
(Japan
Task
Force)
used
to
compare
critical
outcomes
patients
with
(fifth,
N
=
735)
vs
waves
(sixth,
495;
seventh,
128).Patients
sixth
had
a
lower
incidence
respiratory
outcomes,
higher
bacterial
infection,
although
mortality
rate
did
differ
significantly
waves.
In
waves,
138
(27.9%)
29
(22.7%)
were
unvaccinated,
respectively.
Multivariable
analysis
adjusted
previously
reported
factors
revealed
that
proportion
(1)
(2)
decreased
frequency-dependent
manner.
Thus,
(the
number
vaccinations):
1-2
times:
odds
ratio
(aOR)
0.37
(95%
confidence
interval
[CI];
0.20-0.69);
3-4
aOR
0.25
CI;
0.11-0.58);
0.43
0.27-0.66);
0.36
0.21-0.60).Patients
infections
showed
than
those
infections,
may
contribute
preventing
failure.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(2), P. e0299700 - e0299700
Published: Feb. 28, 2024
Background
In
the
global
aging,
coronavirus
disease
2019
(COVID-19)
pandemic
may
have
affected
place
of
death
(PoD)
in
Japan,
where
hospital
deaths
dominated
for
decades.
We
analyzed
PoD
trends
before
and
during
COVID-19
Japan.
Methods
This
nationwide
observational
study
used
vital
statistics
based
on
certificates
from
Japan
between
1951
2021.
The
proportion
PoD;
at
home,
hospitals,
nursing
homes;
annual
percentage
change
(APC)
were
estimated
using
joinpoint
regression
analysis.
Analyses
stratified
by
age
groups
causes
death.
Results
After
2019,
home
exhibited
upward
trends,
while
turned
into
downward
trends.
By
age,
no
significant
trend
was
seen
0–19
group,
decreased
20–64
group
2019.
≥65
significantly
increased
since
with
an
APC
12.3%
(95%
confidence
interval
[CI]:
9.0
to
15.7),
their
−4.0%
CI:
−4.9
−3.1)
2019−2021.
cause
death,
due
cancer
old
29.3%
25.4
33.2)
8.8%
5.5
12.2),
respectively.
Conclusion
has
shifted
majority
whom
older
population
or
age.
Circulation Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Coronary
artery
calcification
(CAC)
detected
through
chest
computed
tomography
(CT)
strongly
predicts
cardiovascular
events
in
asymptomatic
individuals
undergoing
primary
prevention.
Few
studies
with
limited
sample
sizes
have
investigated
the
predictive
value
of
CAC
for
complications
COVID-19.
This
study
examined
impact
on
using
a
large-scale
COVID-19
database.
multicenter
retrospective
cohort
used
data
from
Japan
Task
Force
After
exclusion
based
missing
information,
1,109
patients
were
included.
The
Agatston
score
was
to
evaluate
CAC,
dividing
population
into
3
groups
degree
(no,
moderate,
and
severe
CAC).
outcome
complications;
secondary
critical
outcomes.
group
had
higher
rate
than
other
groups.
Multivariable
analysis,
considering
severity
factors,
identified
as
independently
associated
but
not
Subgroup
analysis
revealed
that,
without
hypertension,
diabetes,
disease,
or
chronic
kidney
significantly
correlated
complications,
whereas
this
association
observed
these
underlying
conditions.
Patients
increased
identifying
pulmonary
findings
CT
is
essential.
Measuring
via
non-electrocardiogram-gated
helps
predict
patient
risk.
Journal of Cachexia Sarcopenia and Muscle,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 27, 2025
ABSTRACT
Background
Chest
computed
tomography
(CT)
is
a
valuable
tool
for
diagnosing
and
predicting
the
severity
of
coronavirus
disease
2019
(COVID‐19)
assessing
extrapulmonary
organs.
Reduced
muscle
mass
visceral
fat
accumulation
are
important
features
body
composition
phenotype
in
which
obesity
loss
coexist,
but
their
relationship
with
COVID‐19
outcomes
remains
unclear.
In
this
study,
we
aimed
to
investigate
association
between
erector
spinae
(ESM)
epicardial
adipose
tissue
(EAT)
ratio
(ESM/EAT)
on
chest
CT
patients
COVID‐19.
Methods
We
analysed
data
from
1074
enrolled
Japan
Task
Force
database.
The
primary
outcome
was
rate
critical
(requiring
high‐flow
oxygen
therapy,
invasive
ventilator
support
or
death).
incidence
compared
high
low
ESM/EAT
ratios.
Results
group
(
n
=
353)
had
higher
(13.3%
vs.
5.13%,
p
<
0.001)
mortality
(2.55%
0.69%,
0.019)
than
721).
multivariable
analysis,
associated
(adjusted
odds
[aOR]
2.11,
95%
confidence
interval
[CI]
1.22–3.66)
independently
known
factors
including
age,
sex,
index
(BMI),
smoking
history,
lifestyle‐related
comorbidities
pneumonia
volume.
Conclusion
can
be
obtained
used
predict
after
onset,
demonstrating
importance
detailed
assessments
practice.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 19, 2025
Predictive
models
for
determining
coronavirus
disease
2019
(COVID-19)
severity
have
been
established;
however,
the
complexity
of
interactions
among
factors
limits
use
conventional
statistical
methods.
This
study
aimed
to
establish
a
simple
and
accurate
predictive
model
COVID-19
using
an
explainable
machine
learning
approach.
A
total
3,301
patients
≥
18
years
diagnosed
with
between
February
2020
October
2022
were
included.
The
discovery
cohort
comprised
whose
onset
fell
before
1,
(N
=
1,023),
validation
remaining
2,278).
Pointwise
linear
logistic
regression
used
extract
41
features.
Reinforcement
was
generate
high
accuracy.
primary
evaluation
area
under
receiver
operating
characteristic
curve
(AUC).
achieved
AUC
0.905
four
features:
serum
albumin
levels,
lactate
dehydrogenase
age,
neutrophil
count.
highest
value
0.906
(sensitivity,
0.842;
specificity,
0.811)
in
0.861
0.804;
0.675)
cohort.
Simple
well-structured
established,
which
may
aid
patient
management
selection
therapeutic
interventions.
Environmental Health and Preventive Medicine,
Journal Year:
2023,
Volume and Issue:
28(0), P. 35 - 35
Published: Jan. 1, 2023
Many
previous
studies
have
reported
that
COVID-19
vaccine
effectiveness
decreased
over
time
and
declined
with
newly
emerging
variants.
However,
there
are
few
such
in
Japan.
Using
data
from
a
community-based
retrospective
study,
we
aimed
to
assess
the
association
between
vaccination
status
severe
outcomes
caused
by
Omicron
variant,
considering
length
of
since
last
dose.We
included
all
persons
aged
≥12
diagnosed
doctor
notified
Chuwa
Public
Health
Center
Nara
Prefectural
Government
during
BA.1/BA.2
BA.5-predominant
periods
Japan
(January
1
September
25,
2022).
The
outcome
variable
was
health
consequences
(SHC)
(i.e.,
COVID-19-related
hospitalization
or
death).
explanatory
individuals
number
vaccinations
dose).
Covariates
gender,
age,
risk
factors
for
aggravation,
hospital
beds
per
population.
generalized
estimating
equations
multivariable
Poisson
regression
models,
estimated
cumulative
incidence
ratio
(CIR)
95%
confidence
interval
(CI)
SHC,
stratified
analyses
period
(BA.1/BA.2
BA.5)
age
(65
older
12-64
years).Of
69,827
participants,
2,224
(3.2%)
had
12,154
(17.4%)
were
unvaccinated,
29,032
(41.6%)
received
≥3
doses.
Regardless
significant
dose-response
relationship
which
adjusted
CIR
SHC
an
increased
longer
vaccination.
On
one
hand,
BA.5
period,
those
≥175
days
after
third
dose
no
difference
people
65
(CIR
0.77;
CI,
0.53-1.12),
but
significantly
lower
0.47;
0.26-0.84),
compared
≥14
second
dose.A
higher
associated
against
both
sublineages.
Our
findings
suggest
increasing
doses
can
prevent
outcomes,
biannual
is
recommended
people.
Acute Medicine & Surgery,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Jan. 1, 2023
Multisystem
inflammatory
syndrome
in
adults
(MIS-A)
is
a
hyperinflammatory
multisystem
condition
associated
with
coronavirus
disease
(COVID-19).
Critically
ill
COVID-19
patients
may
develop
multiorgan
damage
and
elevated
responses,
thus
making
it
difficult
to
differentiate
between
progression
organ
due
itself
or
MIS-A.
This
study
aimed
explore
the
characteristics
complications
of
MIS-A
critical
patients.