Use of wastewater from passenger ships to assess the movement of COVID-19 and other pathogenic viruses across maritime international boundaries

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: July 15, 2024

The worldwide spread of SARS-CoV-2 and the resulting COVID-19 pandemic has been driven by international travel. This led to desire develop surveillance approaches which can estimate rate import pathogenic organisms across borders. aim this study was investigate use wastewater-based for viral pathogens on commercial short-haul (3.5 h transit time) roll-on/roll-off passenger/freight ferries operating between UK Republic Ireland.

Language: Английский

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The Use of Wastewater Surveillance to Estimate SARS-CoV-2 Fecal Viral Shedding Pattern and Identify Time Periods with Intensified Transmission

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Wastewater-based surveillance is an important tool for monitoring the COVID-19 pandemic. However, it remains challenging to translate wastewater SARS-CoV-2 viral load infection number, due unclear shedding patterns in and potential differences between variants.

Language: Английский

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Comparative Epidemiological and Clinical Outcomes on COVID-19 and Seasonal Influenza Hospitalized Patients during 2023

Infectious Disease Reports, Journal Year: 2024, Volume and Issue: 16(5), P. 783 - 793

Published: Aug. 23, 2024

COVID-19 and influenza are highly contagious respiratory viral diseases priority global public health concerns. We conducted a retrospective observational study of and/or hospitalized cases, during 2023. identified 170 150 cases 3 co-infections. Overall, 29.10% patients had at least one vaccine dose 4.6% received the seasonal Flu vaccine. The demographic data found older in group higher index comorbidities, mainly due to chronic heart diseases, hypertension, diabetes. Fever, chills, rhinorrhea were more frequently related influenza, while cough was prevalent COVID-19. Antibiotics used than COVID-19, either pre-hospital or in-hospital. mortality rate within first 30 days from onset infection compared concluded that clinical picture is changing influenza-like symptoms. evolution variable, but frequent severe forms. All through 2023, poor vaccination rates, have continued cause numerous hospitalizations, new strategy for efficient vaccinations required.

Language: Английский

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Implications of Dysnatremia and Endocrine Disturbances in COVID-19 Patients

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9856 - 9856

Published: Sept. 12, 2024

Sodium imbalance is a common electrolyte disturbance in COVID-19, often linked to disruptions hormonal regulation. This review explores the relationship between sodium dysregulation and endocrine disturbances, particularly focusing on primary secondary hypothyroidism, hypocortisolism, renin-angiotensin-aldosterone system (RAAS). Hypocortisolism due adrenal insufficiency or pituitary dysfunction, can lead hyponatremia through inadequate cortisol levels, which impair renal free water excretion enhance antidiuretic hormone (ADH) secretion. Similarly, hypothyroidism associated with decreased blood flow glomerular filtration rate (GFR), also increases ADH activity, leading retention dilutional hyponatremia. Furthermore, COVID-19 disrupt RAAS (primarily its interaction angiotensin-converting enzyme 2 (ACE2) receptor), diminishing aldosterone secretion further contributing loss These suggest that multifactorial warrants investigation into complex interplay function, homeostasis. Future research should focus understanding these mechanisms develop management algorithms address both underlying disturbances order improve prognosis outcomes patients.

Language: Английский

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Persistent Health and Cognitive Impairments Up to Four Years Post-COVID-19 in Young Students: The Impact of Virus Variants and Vaccination Timing

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 69 - 69

Published: Dec. 30, 2024

Background: The long-term consequences of COVID-19 infection are becoming increasingly evident in recent studies. This repeated cross-sectional study aimed to explore the health and cognitive effects COVID-19, focusing on how virus variants, vaccination, illness severity, time since impact post-COVID-19 outcomes. Methods: We examined three cohorts university students (N = 584) used non-parametric methods assess correlations various variables with SARS-CoV-2 infection, vaccination status, variants. Results: Our results suggest that some impairments may persist, even appearing progressively worsen-particularly fatigue women memory men-up four years post-infection. data further indicate ancestral variant have most significant impact, while Omicron appears least. Interestingly, severity acute was not correlated SARS-CoV-2. analysis also revealed individuals who contracted after had better outcomes compared those infected before vaccination. Conclusions: Overall, our young predominantly experienced only mild forms a gradual decline fitness can occur over span Notably, negative trends-at least men-only began stabilize or reverse during fourth year, whereas women, these trends showed no such improvement. These findings public impacts be more severe affect much broader population than is commonly assumed.

Language: Английский

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Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID

Brain Communications, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 11, 2024

Abstract Persistent symptoms after COVID-19 constitute the long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). vaccines reduce gravity ensuing infections. However, whether have an impact on PASC remain unknown. We investigated vaccination prior to alters subsequent neurologic (Neuro-PASC). studied prospectively first consecutive 200 post-hospitalization Neuro-PASC (PNP) and 1100 non-hospitalized (NNP) patients evaluated at our neuro-COVID-19 clinic between May 2020 January 2023. Among PNP patients, 87% had a pre-vaccination 13% breakthrough post-vaccination. NNP 70.7% 29.3% infection. Both more frequent pre-existing depression/anxiety than their respective groups, comorbidities headache, lung gastrointestinal diseases group. An average 10 months symptom onset, three most common neurological for were brain fog (86.5%), numbness/tingling (56.5%) headache (56.5%). Of all symptoms, frequently reported anosmia compared (69.2 versus 37.9%; P = 0.005). For (83.9%), (70.9%) dizziness (53.8%). (56.6 39.1%; < 0.0001) dysgeusia (53.3 37.3%; patients. (61.5 50.6%; 0.001). impaired quality-of-life in cognitive, fatigue, sleep, anxiety depression domains with no differences groups. performed worse National Institutes Health Toolbox tests processing speed, attention, executive function working memory US normative population whereas lower results processing, attention memory, without These indicate that does not affect manifestations either or Minor groups may be caused by strains evolution. Patients developing higher burden comorbidities, highlighting different risk factors warranting targeted management.

Language: Английский

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