The role of co-infections and hormonal contraceptives in cervical intraepithelial neoplasia prevalence among women referred to a tertiary hospital in Western Kenya

Infectious Agents and Cancer, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 24, 2025

Screening for co-infections with HIV, HSV-2 and Chlamydia trachomatis (CT) among high-risk human papilloma virus (hr-HPV) positive women, coupled enhanced counseling on contraceptives use remains essential in alleviating high morbidity of cervical cancer (CC). The aim this study was to determine the prevalence intraepithelial neoplasia (CIN) women referred CC screening at a referral hospital Kisumu County, Kenya; establish role co-infection hormonal CIN. In cross-sectional study, we collected HPV, CT data, cytology results, demographic information from 517 referrals. Blood samples were obtained HIV tests; urine test, swabs hr-HPV test colposcopic biopsy histology confirmation after visual inspection acetic acid (VIA). overall CIN 18.4% (95/517) CIN1 observed 56(29.6%), CIN2 27(`14.3%), CIN3 above (CIN3+) 12(6.3%) normal 94(49.7%) patients out which grade (CIN2+) 7.54% (39/517) equivalent 32.5 per 100,000 year. univariate analysis; HPV/HIV (infected vs. uninfected: OR 2.79; 95% CI 1.56–5.10, p < 0.001); HPV/HSV-2 2.41; CI: 1.12–5.46, 0.024); HPV/CT 3.83; 1.84–8.51, 0.001) found be significantly associated Additionally, hormone-containing intra uterine device (HIUD) (users none users: 1.43; 0.28–10.9, 0.017) also Co-infections or HIUD increased risk testing HPV women. Although high, high-grade + comparable rates reported earlier. Therefore, population alongside is desirable likely reduce burden region. Besides, opting ought counseled about possible negative side-effects different contraception options.

Language: Английский

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Mixed Infections in the Female Lower Genital Tract: Unlocking the Current Landscape and Future Directions

Current Medical Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

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The role of co-infections on cervical intraepithelial neoplasia prevalence in western Kenya

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Background Screening for co-infections with HIV, HSV-2 and Chlamydia trachomatis (CT) among high-risk human papilloma virus (hr-HPV) positive women remains essential in alleviating high morbidity of cervical cancer (CC). The aim this study was to determine the prevalence intraepithelial neoplasia (CIN) referred CC screening at a referral hospital Kisumu County, Kenya; establish role co-infection on CIN. Method In cross-sectional study, we collected HPV, CT data, cytology results, demographic information from 517 referrals. Blood samples were obtained HIV tests; urine test swabs hr-HPV test. Results overall CIN 18.4% (95/517) CIN1 observed 56(29.6%), CIN2 27(`14.3%), CIN3 + 12(6.3%) normal biopsy 94(49.7%) patients out which grade above (CIN2+) 7.54% (39/517) equivalent 32.5 per 100,000 year. HPV/HIV (infected vs. uninfected: OR 2.79; 95% CI 1.56–5.10, p < 0.001); HPV/HSV-2 2.41, CI: 1.12–5.46, 0.024); HPV/CT 3.83; 1.84–8.51, 0.001) found be significantly associated Conclusion Overall region although high-grade remained relatively lower as reported earlier. Age factor, widowhood or trachomatis increased risk testing

Language: Английский

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Retrospective study on the characteristics of common urogenital tract pathogens in Beijing

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Background: This study aims to investigate the infection status of Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Ureaplasma urealyticum (UU) among male female patients in Beijing, with objective providing a foundation for clinical diagnosis treatment. Methods: A comprehensive collection 7,373 urine vaginal swab samples was obtained from admitted China-Japan Friendship Hospital between December 2019 March 2024. The detection MG-RNA, CT-RNA, NG-RNA, UU-RNA performed using real-time fluorescent nucleic acid isothermal amplification assay (SAT). Subsequently, analyzed across different variables, including sex, age, diagnosis. Results: overall positive rates MG, CT, NG, UU all were 2.70% (199/7373), 3.76% (277/7373), 1.84% (136/7373), 21.99% (1621/7373), respectively. Notably, rate significantly higher compared other three pathogens, difference being statistically significant (P < 0.01). Among patients, 2.76% (173/6268), 3.72% (233/6268), 1.99% (125/6268), 16.16% (1013/6268), In females, 2.35% (26/1105), 3.98% (44/1105), 1.00% (11/1105), 55.02% (608/1105), females than that males, whereas NG males females. These differences 0.05). Conclusions: is predominant urogenital tract both Beijing area. Therefore, it imperative enhance early screening monitoring treatment, initiate intervention.

Language: Английский

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