Invasive Aspergillosis in the Intensive Care Unit

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(1), P. 70 - 70

Published: Jan. 17, 2025

Invasive aspergillosis (IA) is a fungal infection, which has traditionally been associated with neutropenia and immunosuppressive therapies. Our understanding of invasive evolving and, in the past few decades, IA among ICU patients recognized as common infection become more widely recognized. The diagnosis management particularly challenging, due to unstable clinical condition patients, lack diagnostic markers, increased risk further deterioration, multiple comorbidities, need for early assessment treatment. In this article, we will discuss challenges pitfalls an setting, along review current literature that pertinent specific population.

Language: Английский

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Effect of Secondary Infections on the Outcomes of Patients with Hematological Malignancies and SARS-CoV-2 Infection: Results from the HM-COV 3.0 Study

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 274 - 274

Published: Feb. 16, 2025

Patients with hematological malignancies (HMs) are at higher risk of severe COVID-19 and secondary infections, which further complicate their outcomes. This study evaluated the impact infections (SIs) on mortality in hospitalized HM patients SARS-CoV-2 infection identified factors associated SIs. We included 217 HMs admitted to a tertiary hospital Rome, from April 2020 September 2022. SIs occurred 44.2% patients, bloodstream (42.7%) respiratory (30.5%) being most frequent; among latter, COVID-19-associated pulmonary aspergillosis (CAPA) was observed 41.4% cases. Viral reactivations, predominantly CMV, 9.2% patients. The overall rate 29%, (47.4% vs. 14.7%, p < 0.01). Risk for (OR = 2.957, 0.05) prolonged hospitalization 1.095, 0.001). Severe 8.229, 0.001), intensive care unit (ICU) admission 15.232, chronic steroid therapy 2.803, 0.05), 2.892, viral reactivation 6.269, 0.01) were independent predictors mortality. reactivations common significantly increase mortality, highlighting need timely management preventive strategies this vulnerable population.

Language: Английский

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Incidence and Risk Factors of COVID-19-Associated Pulmonary Aspergillosis in Severe Cases: A Single-Center Study from Japan

Journal of Infection and Chemotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 102676 - 102676

Published: March 1, 2025

Language: Английский

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Predicting COVID 19–Associated Pulmonary Aspergillosis Risk in Low- and Middle-Income Countries: A Matched Case-Control Study

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(7)

Published: June 28, 2024

Abstract Background Coronavirus disease 2019 (COVID-19)–associated pulmonary aspergillosis (CAPA) is a life-threatening fungal infection. Studies focusing on CAPA in low- and middle-income countries are limited. Methods This retrospective matched case-control study was conducted at tertiary care center South India. Cases of were classified using the 2020 European Confederation Medical Mycology/International Society for Human Animal Mycology consensus criteria. A total 95 cases 1:1 with COVID-19 patients without CAPA. Matching done based age period admission. Inverse probability weighting used to account imbalances severity intensive unit (ICU) Data demographics, clinical details, microbiologic radiologic data, treatment outcomes collected. predictive score developed from baseline risk factors. Results The identified lymphopenia, Organisation Research Treatment Cancer factors, broad-spectrum antibiotic use as main factors Positivity bacterial pathogens blood or bronchoalveolar lavage samples reduced model performed well cross-validation, an area under curve value 82%. diagnosis significantly increased mortality shift ICU. Conclusions derived current offers valuable tool clinicians, especially high-endemic countries, early identification With further validation, this could improve patient outcomes.

Language: Английский

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ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ MỘT SỐ YẾU TỐ TIÊN LƯỢNG TỬ VONG CỦA BỆNH NHÂN ASPERGILLUS PHỔI LIÊN QUAN ĐẾN COVID-19 TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Tạp chí Y học Việt Nam, Journal Year: 2024, Volume and Issue: 541(2)

Published: Aug. 19, 2024

Mục tiêu: Mô tả các đặc điểm lâm sàng, cận sàng của bệnh Aspergillosis phổi liên quan đến COVID-19 (COVID-19-associated pulmonary Aspergillosis- CAPA) và tìm hiểu một số yếu tố tiên lượng tử vong. Đối tượng phương pháp: hồi cứu 65 nhân có thở máy tại Bệnh viện Nhiệt đới Trung ương từ tháng 5 năm 2021 2022, thu thập về biểu hiện kết quả điều trị đánh giá Kết quả: Tỷ lệ là 23,4% trong tổng những máy, với tỷ vong 64,6%. Tuổi trung bình 64,9 tuổi, 42 mắc nền trở lên chiếm 64,6%, đó tăng huyết áp 28 (43,1%) đái tháo đường 11 (16,9%) nhân. Các chủng được xác định Aspergillus fumigatus 58 trường hợp 89,2% flavus 07 10,8%. Yếu mạn tính, áp, đường, thời CAPA sốc nhiễm khuẩn, giảm bạch cầu lympho máu dưới 1,0 G/l, tiểu 150 cần hỗ trợ FiO2 ≥60% trên SOFA ≥7. độc lập tính khuẩn ở bắt đầu CAPA.

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Invasive Fungal Infections in Immunocompromised Conditions: Emphasis on COVID-19

Current Microbiology, Journal Year: 2024, Volume and Issue: 81(11)

Published: Oct. 9, 2024

Language: Английский

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