The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis
International Journal of COPD,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 709 - 722
Published: March 1, 2025
Recently,
numerous
studies
have
explored
the
potential
impact
of
gut
microbiota
on
Chronic
Obstructive
Pulmonary
Disease
(COPD).
However,
causal
relationship
between
skin
and
COPD,
as
well
differences
similarities
relationships
has
not
been
thoroughly
studied.
We
conducted
a
comprehensive
two-sample
Mendelian
randomization
(MR)
analysis
to
investigate
COPD.
The
inverse
variance
weighted
(IVW)
method
was
used
primary
approach.
MR-Egger,
median,
MR-PRESSO
methods
were
supplementary
approaches.
Various
sensitivity
stability
analyses
validate
results.
Genetic
variations
obtained
from
FR02
cohort
study.
derived
KORA
FF4
PopGen
cohorts,
with
total
1,656
samples.
GWAS
data
for
COPD
FinnGen
consortium,
including
18,266
cases
311,286
controls
European
cohorts.
results
IVW
MR
showed
that
10
microbiotas
4
negatively
associated
[p
<
0.05,
odds
ratio
(OR)
1];
3
6
positively
(p
OR
>
1).
None
them
heterogeneous
or
horizontally
pleiotropic
0.05)
reverse
causality.
This
study
revealed
offering
fresh
perspectives
prevention,
diagnosis,
management
Language: Английский
Editor response for version 1
Published: Dec. 16, 2024
This
study
investigates
the
genomic
basis
of
heavy
metal
resistance
in
Staphylococcus
warneri
strain
TWSL_1,
isolated
from
effluent
a
textile
dyeing
industry
Sri
Lanka.
The
exhibited
substantial
to
Cd2+,
Pb2+,
and
Cu2+,
with
minimum
inhibitory
concentrations
50
mg/L,
1200
75
respectively.
Phylogenetic
analysis
16S
rRNA
gene
confirmed
its
placement
within
clade.
Whole
genome
sequencing
revealed
2,661,318
bp
2,567
coding
sequences
99.81%
average
nucleotide
identity
S.
WS479.
Key
genes
were
identified
through
comparative
analysis,
including
those
encoding
cadmium
efflux
system
accessory
protein
uniquely
present
TWSL_1
but
absent
aureus
RF122.
also
harbored
associated
cobalt-zinc-cadmium
underscoring
TWSL_1's
adaptation
stress.
These
findings
highlight
comprehensive
genetic
toolkit
enhancing
resilience
metal-contaminated
environments
demonstrating
potential
for
bioremediation,
supporting
development
eco-friendly
remediation
strategies.
Language: Английский
Reviewer response for version 1
Published: Dec. 15, 2024
This
study
investigates
the
genomic
basis
of
heavy
metal
resistance
in
Staphylococcus
warneri
strain
TWSL_1,
isolated
from
effluent
a
textile
dyeing
industry
Sri
Lanka.
The
exhibited
substantial
to
Cd2+,
Pb2+,
and
Cu2+,
with
minimum
inhibitory
concentrations
50
mg/L,
1200
75
respectively.
Phylogenetic
analysis
16S
rRNA
gene
confirmed
its
placement
within
clade.
Whole
genome
sequencing
revealed
2,661,318
bp
2,567
coding
sequences
99.81%
average
nucleotide
identity
S.
WS479.
Key
genes
were
identified
through
comparative
analysis,
including
those
encoding
cadmium
efflux
system
accessory
protein
uniquely
present
TWSL_1
but
absent
aureus
RF122.
also
harbored
associated
cobalt-zinc-cadmium
underscoring
TWSL_1's
adaptation
stress.
These
findings
highlight
comprehensive
genetic
toolkit
enhancing
resilience
metal-contaminated
environments
demonstrating
potential
for
bioremediation,
supporting
development
eco-friendly
remediation
strategies.
Language: Английский