Causal relationship between gut microbiota and myasthenia gravis: a two-sample Mendelian randomization study DOI Creative Commons

Chuanhao Mi,

Ajiao Hou, Ziyue Wang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 25, 2024

Background Previous observational studies have provided cumulative data linking gut microbiota to myasthenia gravis (MG). However, the causal link between two remains unexplored. Hence, current study was performed explore them. Methods Mendelian randomization (MR) analysis conducted using summary statistics of 211 taxa and largest genome-wide association (GWAS) for MG currently available. The inverse variance-weighted (IVW), MR-Egger, weighted median, mode methods were employed ascertain influence. Sensitivity utilizing several methodologies then used assess robustness findings. Lastly, evaluate reverse causality, a MR performed. Results Seven suggestive associations gastrointestinal identified based on outcomes analysis. Specifically, phylum Actinobacteria (OR: 0.602, 95% CI: 0.405–0.896, p = 0.012), class Gammaproteobacteria 0.587, 0.357–0.968, 0.037), families Defluviitaleaceae 0.695, 0.485–0.996, 0.047), Family XIII 0.614, 0.412–0.916, 0.017), Peptococcaceae 0.698, 0.505–0.964, 0.029) had protective effects MG, while order Mollicutes RF9 1.424, 1.015–1.998, 0.041) genus Faecalibacterium 1.763, 1.220–2.547, 0.003) risk factors MG. indicate that neither heterogeneity nor horizontal pleiotropy any discernible impact. Nevertheless, this did not reveal apparent effect composition. Conclusion investigation has substantiated connection which may provide helpful insights innovative therapeutic preventative approaches Further randomized controlled trials are needed elucidate microbiota’s precise role potential in pathogenesis

Language: Английский

Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies DOI
Ying Gao, Qingyang Li, Luyao Yang

et al.

Sports Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

6
Prolonged sitting time and all-cause mortality: the mediating and predictive role of kidney function markers DOI Creative Commons
Li Wang, Xiajia Wu, Ziyi Guo

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: April 22, 2025

To investigate the association between daily sitting time and all-cause mortality, with a focus on mediating effect predictive value of makers relating to kidney. The cross-sectional study utilized data from National Health Nutrition Examination Survey (NHANES) 2003 2020. kidney were assessed through estimated glomerular filtration rate (eGFR), urine albumin creatinine ratio (UACR), other relevant markers. A total 9,707 adults included in analysis. There was significant increase levels blood urea nitrogen (BUN), creatinine, uric acid, osmolality, UACR extended time, while eGFR significantly decreased. Notably, individuals ≥ 8 h per day exhibited 67% higher risk mortality (HR = 1.67, 95% CI: 1.43-1.94). nonlinear (L-shaped) relationship observed (p < 0.001) or mortality. Mediation analysis revealed that accounted for 20.98% 0.01). An addition would AUC 0.585 0.762 0.656, respectively(p 0.001). main caused by chronic lower respiratory diseases, diabetes mellitus, cerebrovascular diseases heart diseases. Prolonged is associated an increased potentially mediated impaired function. Incorporating function markers such as enhances assessment sedentary populations.

Language: Английский

Citations

0
Case Report: Neurological adverse events in subject with myasthenia gravis after PCSK9 inhibitor administration DOI Creative Commons
Věra Adámkova,

Martina Vitásková,

Jaroslav A. Hubác̆ek

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: March 12, 2024

Background Myasthenia gravis is a rare chronic autoimmune neuromuscular disorder mainly caused by autoantibodies to the nicotinic acetylcholine receptor. Cholesterol an essential molecule that affects distribution and proper functioning of this Several reports have described potential worsening myasthenia in patients treated with statins. Case presentation The patient was obese 72 years old man, past smoker, diagnosed ischaemic heart disease, type 2 diabetes mellitus lipid metabolism disorder. Statin treatment not implemented because PCSK9i monotherapy [Repatha (evolucamab), 140 mg] treat dyslipidaemia. Within 24 h after first dose developed severe muscle weakness, joint pain, fever, general discomfort, lasting for several days. Despite strong advice against second administration, self-administered approximately weeks later, leading report significant problems, admittion neurology department where he being attack. Conclusion Based on neurologist's conclusion, it can be assumed case, resulted patient's disease.

Language: Английский

Citations

1
Mendelian randomization analyses of known and suspected risk factors and biomarkers for myasthenia gravis overall and by subtypes DOI Creative Commons
Wenwen Wang, Wei Ge,

Feng Jun-ling

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 18, 2024

Abstract Background Myasthenia gravis (MG) is an autoimmune disease that affects neuromuscular junction. The literature suggests the involvement of circulating cytokines (CK), gut microbiota (GM), and serum metabolites (SM) with MG. However, this research limited to observational trials, comprehensive causal relationship studies have not been conducted. Based on published datasets, investigation employed Mendelian Randomization (MR) analyze known suspected risk factors biomarkers association MG its subtypes. Methods This used two-sample MR linkage disequilibrium score (LDSC) regression multiple datasets aggregate acquired from genome-wide (GWAS) assess 41-CK, 221-GM, 486-SM. For sensitivity analysis validate robustness data, six methods were utilized, including MR-Egger regression, inverse variance weighting (IVW), weighted median, MR-PRESSO. Results method identified 20 significantly associated MG, 2 CKs, 6 GMs, 9 SMs. Further related two subtypes, early-onset (EOMG) late-onset (LOMG), showed EOMG had a high overlap in intestinal flora, while LOMG greater similarity CKs Furthermore, LDSC indicated Peptococcaceae , oxidized biliverdin, Kynurenine significant genetic correlations general whereas was highly correlated Intestinibacter associations Glucose. Conclusion furnishes evidence for potential various indicates heterogeneous between SMs

Language: Английский

Citations

0
Causal relationship between gut microbiota and myasthenia gravis: a two-sample Mendelian randomization study DOI Creative Commons

Chuanhao Mi,

Ajiao Hou, Ziyue Wang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 25, 2024

Background Previous observational studies have provided cumulative data linking gut microbiota to myasthenia gravis (MG). However, the causal link between two remains unexplored. Hence, current study was performed explore them. Methods Mendelian randomization (MR) analysis conducted using summary statistics of 211 taxa and largest genome-wide association (GWAS) for MG currently available. The inverse variance-weighted (IVW), MR-Egger, weighted median, mode methods were employed ascertain influence. Sensitivity utilizing several methodologies then used assess robustness findings. Lastly, evaluate reverse causality, a MR performed. Results Seven suggestive associations gastrointestinal identified based on outcomes analysis. Specifically, phylum Actinobacteria (OR: 0.602, 95% CI: 0.405–0.896, p = 0.012), class Gammaproteobacteria 0.587, 0.357–0.968, 0.037), families Defluviitaleaceae 0.695, 0.485–0.996, 0.047), Family XIII 0.614, 0.412–0.916, 0.017), Peptococcaceae 0.698, 0.505–0.964, 0.029) had protective effects MG, while order Mollicutes RF9 1.424, 1.015–1.998, 0.041) genus Faecalibacterium 1.763, 1.220–2.547, 0.003) risk factors MG. indicate that neither heterogeneity nor horizontal pleiotropy any discernible impact. Nevertheless, this did not reveal apparent effect composition. Conclusion investigation has substantiated connection which may provide helpful insights innovative therapeutic preventative approaches Further randomized controlled trials are needed elucidate microbiota’s precise role potential in pathogenesis

Language: Английский

Citations

0