Comparing the maternal and neonatal outcomes in vaccinated and unvaccinated pregnant women against COVID-19: a retrospective cohort study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

Following the emergence of COVID-19 disease, and considering limited number studies regarding vaccination among pregnant women, as well differences between vaccine administered in Iran those used other countries, this study aimed to compare maternal neonatal outcomes vaccinated unvaccinated women against disease. This retrospective cohort was conducted at comprehensive healthcare centers Rafsanjan city. Initially, contact information expectant mothers who were June 22, 2021, December obtained through Iran's integrated system (Sib). Subsequently, required collected via a checklist during phone interviews. Out 969 after applying inclusion exclusion criteria, 610 subjects included study. Among these, 330 unvaccinated, while remaining participants had received inactivated prior or pregnancy. Maternal compared women. Data analysis performed using SPSS version 26, employing one-way variance (ANOVA), Tukey's multiple comparison test, Fisher's exact Chi-square logistic regression. The findings indicated that significantly increased risk jaundice (P < 0.05). Conversely, miscarriage rate these lower No adverse observed including hypertensive disorders, gestational diabetes, hospitalization, infection, preterm labor, premature rupture membranes, perinatal mortality, admission intensive care unit, low birth weight. Vaccination is recommended for mitigate outcomes.

Language: Английский

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In need of robust evidence of non-association of pregestational and early pregnancy SARS-CoV-2 infections with congenital anomalies

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 74, P. 102729 - 102729

Published: July 13, 2024

SARS-CoV-2 infection during pregestational and early pregnancy periods has an unclear impact on fetal development. Although vertical transmission is rare, potential effects the developing brain are plausible. However, robust evidence linking maternal to congenital anomalies limited due inadequate tracking of history methodological flaws in published studies. This further complicated by limitations, such as restricted testing access undiagnosed infections, particularly low- middle-income countries. Most data focus hospitalized women near term, lacking information first- second-trimester infections. Thus, accurate assessment COVID-19 essential. It should however be emphasised that we have vaccination against before or not associated with malformations, ruling out any role vaccines these increased rates abnormalities. viewpoint discusses findings from surveillance registries, highlights study offers research recommendations inform clinical guidelines public health strategies, aiming mitigate viral infections neurodevelopment.

Language: Английский

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Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review

Diagnostics, Journal Year: 2024, Volume and Issue: 14(16), P. 1775 - 1775

Published: Aug. 14, 2024

The COVID-19 pandemic has posed significant risks to pregnant women and those recently pregnant, leading heightened mortality morbidity rates. Vaccination emerged as a pivotal strategy in reducing COVID-19-related deaths illnesses worldwide. However, the initial exclusion of individuals from most clinical trials raised concerns about vaccine safety this population, contributing hesitancy. This review aims consolidate existing literature assess efficacy vaccination populations neonatal outcomes. Diverse studies were included evaluating various aspects for their newborns, encompassing mild severe symptoms across different vaccines. findings indicate overall vaccination, with minimal adverse outcomes observed, including side effects like pain fever. Although reported absence outcomes, isolated case reports have potential associations between maternal conditions such fetal supraventricular tachycardia immune-mediated diseases. Our underscores importance ongoing surveillance monitoring ensure women. Overall, during pregnancy remains safe effective strategy, emphasizing need continued research vigilance safeguard health.

Language: Английский

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Comparing the maternal and neonatal outcomes in vaccinated and unvaccinated pregnant women against COVID-19: a retrospective cohort study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Background After the emergence of COVID-19 disease due to limited number studies on vaccination pregnant mothers and fact that vaccine used in Iran has been different from ones employed other countries, this study aimed compare maternal neonatal outcomes vaccinated unvaccinated women against COVID-19. Methods This retrospective cohort was done comprehensive healthcare centers Rafsanjan city. First, contact information expectant who were 22th June 2021 December extracted using Iran's integrated health care system (SIB); then during a phone call, required registered checklist. Out 969 women, after checking inclusion exclusion criteria, only 610 subjects included study. number, 330 had not vaccinated, while rest received inactivated before or pregnancy. The compared between women. data analyzed SPSS 26 software one-way analysis variance (One-way ANOVA), Tukey multiple comparison, Fisher's exact test Chi-square test, logistic regression. Results results revealed significantly increased probability jaundice neonate (P < 0.05), but miscarriage rate these lower 0.05). No adverse observed such as high blood pressure, gestational diabetes, hospitalization, infection with COVID-19, premature delivery, rupture amniotic sac, perinatal death, admission intensive unit, low birth weight. Conclusions among is recommended prevent outcomes.

Language: Английский

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