Associations between maternal microbiome, metabolome and incidence of low-birth weight in Guatemalan participants from the Women First Trial DOI Creative Commons
Meghan L. Ruebel, Stephanie P. Gilley, Laxmi Yeruva

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 15, 2024

Background Low birth weight (LBW; <2,500 g) affects approximately 15 to 20 percent of global births annually and is associated with suboptimal child development. Recent studies suggest a link between the maternal gut microbiome poor obstetric perinatal outcomes. The goal this study was examine relationships microbial taxa, fecal metabolites, anthropometry on incidence LBW in resource-limited settings. Methods This secondary analysis Women First trial conducted semi-rural region Guatemala. Maternal measured at 12 34 weeks (wk) gestation. Infant measures were collected within 48 h delivery. samples used for (16S rRNA gene amplicon sequencing) metabolomics (34 wk). Linear mixed models using MaAslin2 package utilized assess changes LBW. Predictive gradient boosted machines (XGBoost) developed H2o.ai engine. Results No differences β-diversity observed either time point mothers infants relative normal (NW) infants. Simpson diversity lower Notable genus-level abundance NW ( p < 0.05) increasing abundances Barnesiella , Faecalibacterium Sutterella Bacterioides . At weeks, there Magasphaera Phascolarctobacterium Turicibacter higher Bacteriodes Fusobacterium Fecal metabolites related bile acids, tryptophan metabolism fatty acid changed Classification predict based predicted functions showed moderate performance. Conclusion Collectively, findings indicate that alterations metabolome Future research should target functional predictive roles infant outcomes including birthweight.

Language: Английский

Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications DOI Creative Commons

Yupei Xie,

Qian Chen, Dan Shan

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 7, 2025

The gut microbiota is the collective term for microorganisms that reside in human gut. In recent years, advances sequencing technology and bioinformatics gradually revealed role of health. Dramatic changes occur during pregnancy due to hormonal dietary changes, these have been associated with certain gestational diseases such as preeclampsia (PE) diabetes mellitus (GDM). Modulation has also proposed a potential treatment diseases. present article aims review current reports on association between diseases, explore possible mechanisms, discuss probiotics Uncovering link could lead new therapeutic approach.

Language: Английский

Citations

0
Metabolic-associated fatty liver disease and pregnancy complications: new challenges and clinical perspectives DOI Creative Commons
Yang Zhang, Yifan Bu, Rui Zhao

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

The term metabolic-associated fatty liver disease (MAFLD), with a global prevalence estimated at 38.77%, has gradually replaced the traditional concept of non-alcoholic (NAFLD). Compared to general population, incidence MAFLD is notably higher among pregnant women, posing potential risks both maternal and neonatal health. This review summarizes latest research on MAFLD, focusing its association pregnancy complications. Additionally, it provides comparative analysis previous studies NAFLD, presenting comprehensive perspective for clinical management. Findings suggest that women face risk gestational hypertension cesarean delivery compared those while diabetes mellitus remains similar between two conditions. associated an increased likelihood delivering large-for-gestational-age infants heightened preterm birth low weight. Current treatment strategies focus lifestyle modifications, such as dietary adjustments physical activity. However, there urgent need development safe effective pharmacological treatments, particularly tailored toward women. Future should delve deeper into causal relationships complications explore optimal therapeutic approaches improve outcomes mothers their infants.

Language: Английский

Citations

1
Associations between maternal microbiome, metabolome and incidence of low-birth weight in Guatemalan participants from the Women First Trial DOI Creative Commons
Meghan L. Ruebel, Stephanie P. Gilley, Laxmi Yeruva

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 15, 2024

Background Low birth weight (LBW; <2,500 g) affects approximately 15 to 20 percent of global births annually and is associated with suboptimal child development. Recent studies suggest a link between the maternal gut microbiome poor obstetric perinatal outcomes. The goal this study was examine relationships microbial taxa, fecal metabolites, anthropometry on incidence LBW in resource-limited settings. Methods This secondary analysis Women First trial conducted semi-rural region Guatemala. Maternal measured at 12 34 weeks (wk) gestation. Infant measures were collected within 48 h delivery. samples used for (16S rRNA gene amplicon sequencing) metabolomics (34 wk). Linear mixed models using MaAslin2 package utilized assess changes LBW. Predictive gradient boosted machines (XGBoost) developed H2o.ai engine. Results No differences β-diversity observed either time point mothers infants relative normal (NW) infants. Simpson diversity lower Notable genus-level abundance NW ( p < 0.05) increasing abundances Barnesiella , Faecalibacterium Sutterella Bacterioides . At weeks, there Magasphaera Phascolarctobacterium Turicibacter higher Bacteriodes Fusobacterium Fecal metabolites related bile acids, tryptophan metabolism fatty acid changed Classification predict based predicted functions showed moderate performance. Conclusion Collectively, findings indicate that alterations metabolome Future research should target functional predictive roles infant outcomes including birthweight.

Language: Английский

Citations

0