Lung Adenocarcinoma Patients with ROS1-Rearranged Tumors by Sex and Smoking Intensity

Published: Jan. 1, 2023

Background: ROS1 rearrangements (ROS1+) define a distinct molecular subset of lung adenocarcinomas with sensitivity to ALK/ROS1-targeted therapy. ROS1+ tumors are known occur much likely in patients who were younger and did not smoke cigarettes, but the frequency outcome positivity by sex smoking intensity clearly documented.Methods: This patient cohort study included all never- (<100 cigarettes lifetime) light- (100 cigarettes-20 pack-years) smokers, sample heavy-smokers. rates compared within beyond our study. Survival outcomes analyzed using Kaplan-Meier curves Cox proportional hazards models. Results: Of 571 total patients, was detected 24 (4.2%): 6.4% men 3.0% women; 5.1% never-, 5.7% light-, 1.8% heavy-smokers (P=0.05). Among 209 stage IIIB-IV had higher rate (11.1%) only than women (1.7%, P=0.004) study, also that 8 published studies, where 0.4%-1.8% (Ps=0.0019-0.0001). Furthermore, among heavy-smokers, 9.3%, 8.1% 1.2%, respectively, pointing similar between light-smokers significantly (P=0.017). We confirmed smoking-intensity specific 6 studies (Ps=0.041-0.0001). After adjusting for covariates, overall survival better ROS1- (P=0.023), mainly due targeted Follow-up treatment four entrectinib lorlatinib showed remarkable benefits.Conclusions: The women, light-smokers, more pronounced patients. Newer-generation drugs brought crizotinib resistant These results, when further validated, could assist future trials designed efficiently accrue

Language: Английский

Contribution of Next Sequencing Generation in Lung Cancer and Its Prognostic Implication

Medical Research Archives, Journal Year: 2023, Volume and Issue: 11(10)

Published: Jan. 1, 2023

Lung cancer is one of the most commonly diagnosed cancers worldwide. It leading cause cancer-related deaths in both men and women. In 2020, there were an estimated 2.2 million new cases lung 1.8 due to disease. Historically, has been more common men, but gap closing. Smoking tobacco cancer. Survival rates for vary greatly depending on stage at diagnosis other factors. Overall, prognosis often poor, with a relatively low five-year survival rate compared some cancers. this work we aim show paths cancer, through study several mutations proteins, mostly detected by Next-generation sequencing (NGS) which significantly transformed our understanding providing high-throughput cost-effective methods analyzing genomic information. context NGS played crucial role advancing knowledge disease, improving treatment, guiding personalized medicine approaches. key points highlighting importance next-generation cancer: Comprehensive Genomic Profiling Identification Driver Mutations Stratification Patients Predicting Treatment Response Monitoring Disease Progression Clinical Trials Drug Development Early Detection Prognosis A large meta-analysis done, as well detailed 86 patients ANALIZA laboratory. sense frequently implicated tumor have analyzed, ALK, ROS1 EGFR, positions they occupy genes, addition programmed death ligand 1 (PD-L1), immune control protein, expressed activated cells cells, how its identification allows us direct treatment optimal way. summary, revolutionized field research clinical practice. By insights into landscape tumors, facilitates approaches, early detection, ongoing monitoring, ultimately improved patient outcomes.

Language: Английский