Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 1, 2025

ABSTRACT Background Immune system modulation has been shown to have a significant impact on attention deficit hyperactivity disorder (ADHD). Mendelian randomization (MR) analysis was used in this study investigate the potential role of different immune cells development ADHD provide therapy and preventative alternatives. Methods In study, 731 risk were examined using publicly accessible genetic data two‐sample MR analysis. Included four types immunological profiles: determinate (DC), proportional (PC), median brightness level (MBL), morphological characteristics (MA). It discovered that single‐nucleotide polymorphisms (SNPs) are linked ADHD. To evaluate dependability results, we conducted sensitivity (heterogeneity pleiotropy) employed supplementary techniques, such as inverse variance weighted (IVW) MR‐Egger. Graphs display final findings pertinent analyses. Results Following analysis, associated with few low p value phenotypes may influence ADHD, these serve an inspiration for clinical treatment practices aim prevent cure cell both increase worsen likelihood having identified by IVW results. These included CD27 memory B (OR = 1.066, 95% CI 1.024–1.109, 2E−3) IgD − CD38 1.059, 1.018–1.103, 5E−3), among others. act safeguard against CD3 resting Treg 0.925, 0.888–0.963, 1.5E−4) SSC‐A monocytes 0.951, 0.924–0.980, 8.5E−4), The primary outcomes matched. Conclusions This provides broad theoretical foundation immune‐oriented therapeutic strategies future practice demonstrating relationship between also advances our understanding how use pathway treat

Language: Английский

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White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

This study aimed to investigate the potential association between white blood cell counts and risk of lung cancer, including its subtypes, through Mendelian randomization (MR) analysis. We conducted a two-sample MR analysis using genome-wide (GWAS) summary statistics for both exposure traits (eosinophil count, neutrophil lymphocyte monocyte basophil total count) outcome (lung cancer subtypes). The GWAS dataset included 29,266 cases (11273 adenocarcinoma (LUAD), 7426 squamous carcinoma (LSCC), 2664 small (SCLC)) 56,450 controls. In analysis, we employed methods such as Inverse variance weighted (IVW), median, MR-Egger regression, pleiotropy residual sum outlier. revealed an elevated (WBC) count significantly increased LUAD (IVW: OR = 1.484, 95% CI 1.219–1.749, p 0.003). results confirmed causal relationship 1.687, CI:1.542–1.830, < 0.001). An WBC was associated with higher LUAD. Additionally, subtypes indicated that plays crucial role in

Language: Английский

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Assessing the causal association between 731 immunophenotypes and the risk of colorectal cancer: a Mendelian randomization study

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

Emerging research suggested a potential role of immune cells in colorectal cancer (CRC) development. However, the causal relationship between phenotypes and CRC remains elusive. Hence, this two-sample Mendelian randomization (MR) study aimed to explore association. In study, bidirectional, MR analysis multivariate was conducted, leveraging public genetic data. Four types were employed. A comprehensive sensitivity carried out validate robustness, heterogeneity, horizontal pleiotropy results, with Bonferroni correction applied for accurate interpretation. It revealed that four cell significantly associated risk. Specifically, lymphocyte % leukocyte T-cell/B-cell/NK-cell (TBNK) group (odds ratio (OR) = 1.0013, 95% confidence interval (CI): 1.0005–1.0017, P 0.0003, PBonferroni 0.011) CD3 on CM CD8br maturation stages T (OR 1.0014, CI: 1.0006–1.0022, 0.0007, 0.023) positively correlated risk CRC. Conversely, DN (CD4−CD8−) %leukocyte TBNK 0.9990, 0.9984–0.9997, 0.0020, 0.063) herpesvirus entry mediator (HVEM) 0.9989, 0.9982–0.9997, 0.00431, 0.137) exhibited negative association This did not detect any statistically significant impact phenotypes. inferred an Nevertheless, further clinical experimental studies are warranted these findings elucidate underlying mechanisms.

Language: Английский

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Genetic insights into neuroblastoma: the role of immune cell features

Cytokine, Journal Year: 2025, Volume and Issue: 191, P. 156942 - 156942

Published: April 19, 2025

Language: Английский

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Integrated multi-omics analyses revealed the association between rheumatoid arthritis and colorectal cancer: MYO9A as a shared gene signature and an immune-related therapeutic target

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 10, 2024

Language: Английский

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Causal relationship between cancer and immune cell traits: a two-sample mendelian randomization study

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39732 - e39732

Published: Oct. 28, 2024

Language: Английский

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Specific blood metabolite associations with Gout: a Mendelian randomization study

European Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Gout, common metabolic disorders, have poorly understood links with blood metabolites. Exploring these relationships could enhance clinical prevention and treatment strategies.

Language: Английский

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