Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases DOI Open Access
Jan Korbecki, Mateusz Bosiacki,

Maciej Pilarczyk

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 2115 - 2115

Published: May 31, 2024

This review delves into the enzymatic processes governing initial stages of glycerophospholipid (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) triacylglycerol synthesis. The key enzymes under scrutiny include GPAT AGPAT. Additionally, as most AGPATs exhibit LPLAT activity, participating in Lands cycle with similar functions are also covered. begins by discussing properties these enzymes, emphasizing their specificity reactions, notably incorporation polyunsaturated fatty acids (PUFAs) such arachidonic acid docosahexaenoic (DHA) phospholipids. paper sheds light on intricate involvement various diseases, including obesity, insulin resistance, cancer. To underscore relevance cancer processes, a bioinformatics analysis was conducted. expression levels described were correlated overall survival patients across 33 different types using GEPIA portal. further explores potential therapeutic implications inhibiting treatment metabolic diseases By elucidating pathways involved lipid synthesis impact pathological conditions, this contributes to comprehensive understanding targets.

Language: Английский

Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer DOI Creative Commons
Liangjian Ma,

Wunan Huang,

Xiaolei Liang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 8, 2025

Abstract Endometrial cancer (EC) is a significant health threat to women, with recurrence after treatment posing major challenge. While abnormal cholesterol metabolism has been implicated in EC progression, the underlying mechanisms remain unclear. In this study, we identified lanosterol synthase (LSS) as key mediator associated EC. We found that LSS significantly upregulated tissues. Functional assays revealed promotes cell proliferation and migration, inhibits apoptosis, drives tumor growth vivo. Mechanistically, exerts dual effects by accumulating esters, thereby enhancing growth, activating MAPK/JNK signaling pathway. Importantly, inhibition of specific inhibitor Ro 48-8071 not only reduced suppressed xenograft but also inhibited patient-derived tumor-like clusters (PTCs). These findings establish novel oncogene EC, promoting progression through activation ester accumulation, highlight therapeutic potential targeting treatment.

Language: Английский

Citations

0
The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy DOI

Y. Situ,

Pengpeng Zhang, Cangang Zhang

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105708 - 105708

Published: April 22, 2025

Language: Английский

Citations

0
Genetic association of lipids and lipid-lowering drug target genes with Endometrial carcinoma: a drug target Mendelian randomization study DOI Creative Commons

Zhe-Han Yang,

Jun-Pan Chen,

Ming-Hao Wen

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

Background Aberrant lipid metabolism is intricately linked to the development of endometrial cancer, and statin lipid-lowering medications are regarded as promising adjunctive therapies for future management this malignancy. This study employed Mendelian randomization (MR) explore causal association between traits cancer while assessing potential impact drug targets on lower lipids cancer. Method Two-sample was probe carcinoma. Drug-target also utilized identify drug-target genes managing In instances where lipid-mediated effects through particular were notable, impacts these carcinoma risk factors investigated bolster findings. Result No genetically predicted (LDL-C, TG, TC, HDL-C) EC found in two-sample randomization. target randomization, genetic modeling apolipoprotein B (APOB) (OR [95%CI]=0.31, [0.16-0.60]; p =4.73e-04) cholesteryl ester transfer protein (CETP) [95%CI]=1.83, [1.38-2.43]; =2.91e-05) mimicry associated with non-endometrioid Conclusion The results our MR revealed no EC. Among six targets, we observed a significant APOB levels higher CETP an increased endometrioid These findings provide novel insights into importance regulation individuals carcinoma, warranting further clinical validation mechanistic investigations.

Language: Английский

Citations

1
Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases DOI Open Access
Jan Korbecki, Mateusz Bosiacki,

Maciej Pilarczyk

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 2115 - 2115

Published: May 31, 2024

This review delves into the enzymatic processes governing initial stages of glycerophospholipid (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) triacylglycerol synthesis. The key enzymes under scrutiny include GPAT AGPAT. Additionally, as most AGPATs exhibit LPLAT activity, participating in Lands cycle with similar functions are also covered. begins by discussing properties these enzymes, emphasizing their specificity reactions, notably incorporation polyunsaturated fatty acids (PUFAs) such arachidonic acid docosahexaenoic (DHA) phospholipids. paper sheds light on intricate involvement various diseases, including obesity, insulin resistance, cancer. To underscore relevance cancer processes, a bioinformatics analysis was conducted. expression levels described were correlated overall survival patients across 33 different types using GEPIA portal. further explores potential therapeutic implications inhibiting treatment metabolic diseases By elucidating pathways involved lipid synthesis impact pathological conditions, this contributes to comprehensive understanding targets.

Language: Английский

Citations

0