The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy DOI Creative Commons

Martina Milella,

Monica Rutigliano,

Savio Domenico Pandolfo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 717 - 717

Published: May 15, 2025

Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacities believed to be responsible for tumor initiation, progression, recurrence. These exhibit unique metabolic features that contribute their stemness survival in hostile microenvironments. Like non-stem cancer cells, CSCs primarily rely on glycolysis ATP production, akin the Warburg effect. However, also show increased dependence alternative pathways, such as oxidative phosphorylation (OXPHOS) fatty acid metabolism, which provide necessary energy building blocks therapy resistance. The plasticity of enables them adapt fluctuating nutrient availability hypoxic conditions within tumor. Recent studies highlight importance these shifts maintaining CSC phenotype promoting progression. model suggests small, metabolically adaptable drives growth can switch between mitochondrial enhancing under stress dormant states. Targeting metabolism offers promising therapeutic strategy; however, adaptability complicates eradication. A multi-targeted approach addressing various pathways is essential effective elimination, underscoring need further research into specific markers mechanisms distinguish from normal successful intervention.

Language: Английский

The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy DOI Creative Commons

Martina Milella,

Monica Rutigliano,

Savio Domenico Pandolfo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 717 - 717

Published: May 15, 2025

Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacities believed to be responsible for tumor initiation, progression, recurrence. These exhibit unique metabolic features that contribute their stemness survival in hostile microenvironments. Like non-stem cancer cells, CSCs primarily rely on glycolysis ATP production, akin the Warburg effect. However, also show increased dependence alternative pathways, such as oxidative phosphorylation (OXPHOS) fatty acid metabolism, which provide necessary energy building blocks therapy resistance. The plasticity of enables them adapt fluctuating nutrient availability hypoxic conditions within tumor. Recent studies highlight importance these shifts maintaining CSC phenotype promoting progression. model suggests small, metabolically adaptable drives growth can switch between mitochondrial enhancing under stress dormant states. Targeting metabolism offers promising therapeutic strategy; however, adaptability complicates eradication. A multi-targeted approach addressing various pathways is essential effective elimination, underscoring need further research into specific markers mechanisms distinguish from normal successful intervention.

Language: Английский

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