Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both short long durations impact incidence mortality. A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Embase, Google Scholar up to November 1, 2024, identify cohort studies evaluating outcomes. Meta-analysis performed using MetaAnalysisOnline.com a random-effects model estimate pooled hazard ratios (HRs). Results were visualized through Forest Funnel plots. Analysis 43 (35 on incidence, 8 mortality) revealed significant associations Short (≤ 5–6 h) associated with increased (HR 1.29, 95% CI 1.19–1.40, p < 0.01) modestly elevated mortality 1.12, 1.01–1.25, = 0.03). Long (> 8–9 demonstrated stronger 1.46, 1.33–1.60, 1.45, 1.31–1.60, 0.01). Significant heterogeneity observed ( I 2 74–75%), while analyses showed moderate low 35–40%). highlights U-shaped association risk, linked higher These findings underscore the importance balanced as modifiable risk factor prevention strategies provide foundation for Semmelweis Study, prospective workplace investigating role lifestyle factors unhealthy cerebrovascular brain aging.

Language: Английский

Decades of Night-Shift Work Induce Diurnal Disruption and Corneal Adaptations: Evidence from Pentacam Analysis

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 474 - 474

Published: March 23, 2025

We aimed to determine the effects of night-shift work on corneal parameters in thirty-five healthy individuals (24–59 years) a retrospective cohort study. Among them, 12 hospital nurses regularly worked two shifts, spending third their nights awake, whereas 23 age-matched controls never shifts and slept regularly. Measurements were performed at least five times within h. analyzed keratometric front (F) back (B) surfaces, including refractive power flattest steepest axes (K1, K2), astigmatism (Astig); pachymetry (Pachy) thinnest point pupil center, volume relative 10 mm diagonal (Vol D10); surface variance index (ISV). A multilevel mixed-effects linear regression adjusted for age was applied 905 measurements. All exhibited significant periodic fluctuations (p ≤ 0.005). The groups also showed significantly different 0.008), except K1B AstigB. K1/K2 (F B), AstigF, Pachy, ISV differed < 0.0001). Surprisingly, prolonged night shift did not increase ISV, no evidence age-related thinning observed. Long-term exposures change various parameters, reflecting both concomitant adaptive effects. This study highlights impact consistent sleep deprivation properties, warranting further research into understanding long-term work.

Language: Английский

Correction: Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1

BMC Ophthalmology, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 1, 2024

Language: Английский