Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease—A Comprehensive Review
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1762 - 1762
Published: June 4, 2024
Autoimmune
thyroid
diseases
(AITD)
are
among
the
most
frequent
autoimmune
disorders,
with
a
multifactorial
etiology
in
which
both
genetic
and
environmental
determinants
probably
involved.
Celiac
disease
(CeD)
also
represents
public
concern,
given
its
increasing
prevalence
due
to
recent
improvement
of
screening
programs,
leading
detection
silent
subtypes.
The
two
conditions
may
be
closely
associated
common
risk
factors,
including
setting,
changes
composition
diversity
gut
microbiota,
deficiency
nutrients
like
vitamin
D.
This
comprehensive
review
discussed
current
evidence
on
pivotal
role
D
modulating
microbiota
dysbiosis
immune
system
dysfunction,
shedding
light
possible
relevance
an
adequate
intake
this
nutrient
primary
prevention
AITD
CeD.
While
future
technology-based
strategies
for
proper
supplementation
could
attractive
context
personalized
medicine,
several
issues
remain
defined,
standardized
assays
determination,
timely
recommendations
functioning,
longitudinal
studies
randomized
controlled
trials
definitely
establish
causal
relationship
between
serum
levels
onset
Language: Английский
Celiac Disease—Narrative Review on Progress in Celiac Disease
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 959 - 959
Published: March 11, 2025
Celiac
disease
is
defined
as
a
systemic
immunological
disorder
caused
by
gluten
(gliadin
and
other
prolamin)
in
genetically
predisposed
individuals,
who
present
with
variety
of
gluten-dependent
symptoms,
specific
antibodies,
the
presence
HLA
DQ2
DQ8
histocompatibility
antigen,
enteropathy.
Its
prevalence,
depending
on
studied
population
methodology,
estimated
at
0.75-1.6%
general
population.
During
complex
immune
reaction
it
induces,
most
cells
involved
inflammatory
processes
are
activated,
which
leads
to
gradual
atrophy
intestinal
villi
proliferation
enterocytes
within
crypts.
The
pathogenesis
celiac
extremely
complicated
still
subject
research.
According
current
diagnostic
guidelines,
following
criteria
should
be
taken
into
account:
clinical
symptoms
(intestinal
extraintestinal),
antibodies
against
tissue
transglutaminase
IgA
class,
level
total
IgA,
typical
histological
changes
duodenal
biopsies.
Diet-resistant
one
important
challenges,
causing
serious
complications.
Currently,
basic
method
for
treating
an
elimination
diet
(i.e.,
exclusion
products
that
may
contain
from
diet),
however,
new
therapeutic
strategies
being
sought,
mainly
based
supplementation
exogenous
endopeptidases,
modification
response,
use
zonulin
inhibitors
2
inhibitors.
Clinical
trials
drugs
ongoing.
gradually
expanding
knowledge
about
allow
development
both
patients
mild
course,
well
those
diet-resistant.
Language: Английский
Prevalence and Determinants of Profound Vitamin D Deficiency (25-hydroxyvitamin D <10 nmol/L) in the UK Biobank and potential implications for disease association studies
The Journal of Steroid Biochemistry and Molecular Biology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106737 - 106737
Published: March 1, 2025
Language: Английский
Vitamin D and Bone Metabolism in Celiac Disease. The Possibilities of Dietary Correction
А. И. Хавкин,
No information about this author
В.П. Новикова,
No information about this author
E. Kondratyeva
No information about this author
et al.
Педиатрическая фармакология,
Journal Year:
2024,
Volume and Issue:
21(4), P. 375 - 384
Published: Sept. 16, 2024
The
review
describes
the
state
of
vitamin
D
system
and
bone
metabolism
in
celiac
disease,
mechanisms
influence
on
intestinal
mucosa,
risk
factors
that
contribute
to
pathological
changes
bones
disease.
Studies
are
presented
evaluate
mineral
density,
metabolism,
status
patients
with
results
a
discussion
effect
calcium
supplements
course
disease
condition
tissue
this
presented.
Language: Английский