Genes, Journal Year: 2023, Volume and Issue: 14(8), P. 1639 - 1639
Published: Aug. 17, 2023
Severe or chronic stress and trauma can have a detrimental impact on health. Evidence suggests that early-life adversity become biologically embedded has the potential to influence health outcomes decades later. Epigenetics is one mechanism been implicated in these long-lasting effects. Observational studies humans indicate effects of could even persist across generations, although whether not epigenetic mechanisms are involved remains under debate. Here, we provide an overview animals demonstrate DNA methylation, most widely studied mechanisms, summarize findings from animal models demonstrating involvement epigenetics transmission generations. We then describe results scoping review determine extent which terms intergenerational transgenerational used human investigating via mechanisms. end with discussion key areas for future research advance understanding role legacy trauma.
Language: Английский
Citations
26Post-traumatic stress disorder, dyssomnias, and metabolic syndrome
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2024, Volume and Issue: 20(1), P. 58 - 67
Published: March 3, 2024
Post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS) frequently coexist share neurobiological clinical features. In particular, the results of meta-analyses indicate a higher prevalence MetS in patients with PTSD compared to general population. is also recognized risk factor for MetS. This synchronicity can be partially explained by pathogenetic pathways present both conditions. These include genetic factors, dysfunction hypothalamic-pituitary-adrenal axis, chronic low-grade inflammation, oxidative stress, insulin resistance, immune dysregulation. Thus, similar mechanisms are involved worsening development adverse cardiovascular events associated Dyssomnias one characteristic features PTSD. Today, it believed that posttraumatic circadian rhythm disorders core not secondary feature PTSD, which mediate correlates due homeostasis imbalance. At same time, dyssomnias, chronodestruction, depressive part pathogenesis obesity, treatment dyssomnias key tasks prevention comorbid Regulation sleep processes rhythms through exogenous intervention, especially melatonergic drugs, likely preventing treating people who have The purpose this review analyze specifics relationships between MetS, disorders. We conducted search Scopus, Science Direct (from Elsevier), PubMed, including Medline databases. words used were “post-traumatic disorder,” “dyssomnias,” “chronodestruction,” “metabolic syndrome”. identification research findings found during online searches manual searching bibliography publications.
Language: Английский
Citations
8Mental Health Outcomes of Arab and Jewish Populations in Israel a Month after the Mass Trauma Events of October 7, 2023: A Cross-Sectional Survey of a Representative Sample
Psychiatry Research, Journal Year: 2024, Volume and Issue: 339, P. 116042 - 116042
Published: June 15, 2024
Language: Английский
Citations
4An exploratory study on lipidomic profiles in a cohort of individuals with posttraumatic stress disorder
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 2, 2024
Abstract Posttraumatic stress disorder (PTSD) can develop after trauma exposure. Some studies report that women PTSD at twice the rate of men, despite greater exposure in men. Lipids and their metabolites (lipidome) regulate a myriad key biological processes pathways such as membrane integrity, oxidative stress, neuroinflammation brain by maintaining neuronal connectivity homeostasis. In this study, we analyzed lipidome 40 adults with trauma-exposed non-PTSD individuals (n = 20/sex/condition; 19–39 years old). Plasma samples were for lipidomics using Quadrupole Time-of-Flight (QToF) mass spectrometry. Additionally, ~ 90 measures collected, on sleep, mental physical health indices. Poorer sleep quality was associated severity both sexes. The analysis identified total 348 quantifiable known lipid 1951 are yet unknown; part 13 subclasses. After adjusting BMI quality, PTSD, only one subclass, phosphatidylethanolamine (PE) altered, whereas, men 9 out subclasses altered compared to respectively. Severe 22% 5% women, Of changed metabolites, 0.5% (2 PEs cholesterol) common between PTSD. Several sphingomyelins, PEs, ceramides, triglycerides increased severe correlations ceramide cholesterol systolic blood pressure dependent upon sex status. Alterations ceramides linked cardiac metabolic function humans. Thus, disturbed higher body may have contributed changes found
Language: Английский
Citations
4Hospitalizations with post-traumatic stress disorder in France between 2013 and 2022: a nationwide retrospective study
European Psychiatry, Journal Year: 2025, Volume and Issue: 68(1)
Published: Jan. 1, 2025
The lifetime prevalence of PTSD ranges from 6 to 20% and is often associated with comorbid disorders. Despite the significant impact PTSD, specific data on healthcare utilization related remain limited. This study aims characterize PTSD-related hospitalizations in France over past decade. nationwide longitudinal retrospective analyzed 2013 2022 using French National Hospitals Database. Data included discharge records general psychiatric hospitals, detailing demographics, admission/discharge dates, ICD-10 diagnoses, hospitalization specifics. Between 2022, 69,108 patients underwent 125,349 a diagnosis (0.4% all inpatient cases) France. Psychiatric facilities accounted for 74,988 (1% cases France), while hospitals recorded 50,361 (0.02% non-psychiatric cases). percentage inpatients diagnosed increased 0.68 2.22% 0.02 0.04% period. Females were younger both settings had longer stays compared males facilities. Over time, there was decrease median age an increase part-time Mood disorders, stress-related substance use disorders prevalent comorbidities settings. highlights rise France, particularly after 2019, high rates among women individuals. These findings highlight necessity improved care strategies tailored increasing number PTSD.
Language: Английский
Citations
0Cost-effectiveness of Transcendental Meditation (TM) for treating Post-Traumatic Stress Disorder (PTSD)
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0316995 - e0316995
Published: Feb. 6, 2025
Objective A recent trial found that Transcendental Meditation (TM) was an effective non-trauma focused treatment for veterans with Post-Traumatic Stress Disorder (PTSD). The objective of this analysis to examine the cost-effectiveness TM PTSD based on results. Methods Between 2013–2017, 203 were randomized either TM, Prolonged Exposure (PE), or a health education (HE) control. Each group received 12 sessions over weeks. Results indicated non-inferior PE improving outcomes and both superior HE, as hypothesized. proportion participants clinically significant improvement CAPS (≥10 point reduction) = 61%, 42%, HE 32%. Markov model developed estimate using effectiveness data. Intervention costs, care utility values associated response non-response derived from scientific literature. Costs viewed organizational perspective 5-year time horizon (20 3-month cycles). One-way probabilistic sensitivity analyses conducted. dominant strategy in analysis. cost estimated $1504/12 while $2,822 $492, respectively. higher costs therapy offset intervention differences. Findings robust variability. Conclusion In summary, data RCT, improve reduce total Based these results, further trials wider adoption should be considered.
Language: Английский
Citations
0Impact of posttraumatic stress disorder and comorbid psychiatric conditions on suicide reattempts
European journal of psychotraumatology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 12, 2025
Background: Posttraumatic stress disorder (PTSD) is a prevalent psychiatric condition that significantly increases the risk of suicide.
Language: Английский
Citations
0Expanded access to psychedelic treatments: comparing American and Canadian policies
General Psychiatry, Journal Year: 2025, Volume and Issue: 38(1), P. e101894 - e101894
Published: Feb. 1, 2025
Language: Английский
Citations
0Psychometric evaluation of the UCLA PTSD Reaction Index (PTSD RI-5) in a Turkish Clinical sample of trauma-exposed children
European journal of psychotraumatology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 24, 2025
Objective: Trauma victimization is common among children, however, a significant proportion of trauma victims go unrecognized unless they are thoroughly assessed, even in child psychiatry clinics. The aim this study was to evaluate the psychometric properties and diagnostic accuracy Turkish version UCLA PTSD Reaction Index for DSM-5 (PTSD RI-5) clinical sample trauma-exposed children adolescents.
Language: Английский
Citations
0Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment
Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(5)
Published: March 2, 2025
Exposure to traumatic stress is common in the general population. Variation brain's molecular encoding of potentially contributes heterogeneous clinical outcomes response experiences. For instance, only a minority those exposed trauma will develop post-traumatic disorder (PTSD). Risk for PTSD at least partially heritable, with growing number genetic factors identified through GWAS. A major limitation studies that they capture component risk, whereas by definition requires an environmental exposure. Furthermore, extent, timing, and type affects susceptibility. Here, we discuss mechanisms risk together gene × environment interactions, focus on how either might inform screening individuals high disease, reveal biological one day yield novel therapeutics, impact best practices even today. To close, interaction sex, gender, race, implications treatment. Altogether, suggest predicting, preventing, treating require integrating both genotypic information.
Language: Английский
Citations
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