The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 4, 2024

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with virus, a significant proportion them continue to experience issues weeks, months even years acute infection SARS-CoV-2. This persistence clinical symptoms in individuals for at least three onset or emergence new lasting more than two months, without any other explanation alternative diagnosis have named long COVID, long-haul post-COVID-19 conditions, chronic post-acute sequelae (PASC). Long COVID characterized constellation disorders that vary widely their manifestations. Further, mechanisms underlying are not fully understood, which hamper efficient treatment options. review describes predictors common related COVID's effects on central peripheral nervous system organs tissues. Furthermore, transcriptional markers, molecular signaling pathways risk factors such sex, age, pre-existing condition, hospitalization during phase COVID-19, vaccination, lifestyle presented. Finally, recommendations patient rehabilitation management, well therapeutical approaches discussed. Understanding complexity this disease, its across multiple organ systems overlapping pathologies possible paramount developing diagnostic tools treatments.

Language: Английский

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Prevalence of Perinatal Anxiety and Related Disorders in Low- and Middle-Income Countries

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(11), P. e2343711 - e2343711

Published: Nov. 17, 2023

Anxiety disorders are associated with poor maternal and neonatal outcomes. Women in low- middle-income countries (LMICs) thought to be disproportionally burdened by these disorders, yet their prevalence is unclear.

Language: Английский

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Prevalence and factors associated with antenatal depressive symptoms across trimesters: a study of 110,584 pregnant women covered by a mobile app-based screening programme in Shenzhen, China

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 16, 2024

Abstract Background Antenatal depression is a significant public health issue affecting pregnant women both globally and in China. Using data from mobile app-based screening programme, this study explored the prevalence factors associated with antenatal depressive symptoms across different trimesters Shenzhen. Methods A retrospective cross-sectional was conducted on who gave birth any hospital Shenzhen between July 2021 May 2022 underwent using an official maternal infant app at least once during pregnancy. Depressive were evaluated 9-item Patient Health Questionnaire (PHQ-9), cut-off scores of 5 10 for mild high level symptoms, respectively. The each trimester determined by calculating proportion scoring or higher. variety sociodemographic, obstetric, psychological, lifestyle assessed their association symptoms. Chi-square test multivariate logistic regression performed to identify predictors. Results total 110,584 included study, overall 18.0% high-level 4.2%. most prevalent first (10.9%) decreased second (6.2%) third (6.3%). Only small (0.4%) showed persistent all trimesters. Anxiety early pregnancy emerged as predictor Other linked increased risk throughout include lower marital satisfaction, living parents-in-law, experience negative life events, well drinking before Factors reduced multiparity daily physical activity. Conclusions This large-scale provides valuable insights into findings underscore need targeted interventions high-risk groups integration mental care routine services. Continuous, dynamic monitoring ensuring at-risk receive comprehensive follow-up appropriate psychological psychiatric are crucial effectively addressing improving outcomes.

Language: Английский

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A pathway study of factors influencing anxiety in patients with gestational diabetes mellitus

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

This study aims to assess anxiety severity among patients with and elucidate the predominant psychological factors, informing development of targeted management strategies. The cross-sectional recruited 421 GDM via convenience sampling from Guangdong Province, China. Self-administered questionnaires, including Pregnancy-related Anxiety Scale, Simplified Coping Style Questionnaire, Type D Personality Perceived Social Support General Self-Efficacy were utilized gather data. Data analysis was performed using Structural Equation Modeling (SEM) in AMOS 25.0 SPSS 25.0. Among GDM, significantly positively associated negative coping styles (β = 0.190, P < 0.01) personality 0.167, 0.01), indicating their roles exacerbating anxiety. In contrast, positive (β=-0.136, perceived social support (β=-0.206, general self efficacy (β=-0.49, had direct impacts on anxiety, suggesting protective influence. Mediation revealed that exerted significant mediating effects pathway through explaining 16% indirect effect 2.302, 95% CI: 1.411 ~ 3.350) 32% 4.528, 3.231 5.913). identifies key modifiers could mitigate improve pregnancy outcomes.

Language: Английский

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Prevalence and correlates of depressive and anxiety symptoms among pregnant women from an urban informal settlement in Nairobi, Kenya: a community-based cross-sectional study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 26, 2025

Language: Английский

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Associations of Lifestyle Behaviors with Anxiety and Depression in Type 2 Diabetes Mellitus Patients with Hypertension: A Cross-Sectional Study

Psychiatric Quarterly, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

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Virtual reality enhanced mindfulness and yoga intervention for postpartum depression and anxiety in the post COVID era

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 6, 2025

The postpartum period has witnessed increasing rates of depression and anxiety, particularly in the context COVID-19 pandemic, with these conditions often co-occurring being exacerbated by lingering effects long COVID. Traditional interventions, such as mindfulness-based stress reduction (MBSR) yoga, have demonstrated effectiveness alleviating symptoms. However, limitations in-person sessions, especially pandemic-related restrictions, highlight need for accessible, innovative approaches. Integrating Virtual Reality (VR) technology traditional practices presents a novel solution, offering immersive, customizable environments that may enhance engagement therapeutic outcomes. This study evaluates VR-enhanced mindfulness yoga intervention treating anxiety women affected COVID, additional examination underlying physiological markers cognitive control mechanisms. In this randomized controlled trial, 111 were randomly assigned to experimental (VR-enhanced intervention), (traditional sessions), or blank groups using computer-generated randomization. 8-week involved thrice-weekly 60-minute sessions. Outcomes assessed at baseline, post-intervention, 4-week follow-up Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder-7 (GAD-7) scale, salivary cortisol measurements, an emotional Stroop task. group significant improvements both (EPDS: P < 0.001, ηp2 = 0.18) symptoms (GAD-7: 0.17), significantly greater than those observed (P 0.001 comparisons). These strongly correlated (r 0.68, 0.001). Supporting primary outcomes, levels showed decrease 0.13), improved evidenced reduced task conflict effect 0.37). Correlation analysis revealed robust associations between changes short-term long-term demonstrates integrating VR effectively reduces post-COVID era. parallel provide insight into potential mechanisms effects. findings underscore value immersive enhancing approaches addressing post-pandemic context.

Language: Английский

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Major depression among pregnant women attending a tertiary teaching hospital in Northern Uganda assessed using DSM-V criteria

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 26, 2025

Abstract Background Major depression (MD) during pregnancy complicates maternal and neonatal outcomes. Despite its significant impact, there is a lack of evidence on the prevalence associated factors MD among pregnant women in Uganda. We assessed magnitude with attending antenatal care (ANC) at large teaching hospital Northern Methods Between June August 2023, we enrolled aged 18 years or older ANC clinic Gulu Regional Referral Hospital Data were collected using validated semi-structured questionnaire. was evaluated DSM-V criteria defined as having (1) least two weeks either persistent low mood excessive sadness, (2) plus additional symptoms from diagnostic criterion A, for total five symptoms, (3) caused distress problem significantly altered behaviour functionality. Modified Poisson regression analyses robust standard errors constructed to evaluate independently major depression. Adjusted ratio (aPR) whose 95% confidence interval (CI) did not include null value (0) p < 0.05 considered statistically significant. Results 329 participants, mean age 26.1± 5.5 years. Overall, 29.8% ( n = 98) had MD; 37 (11.2%) mild, 49 (14.9%) moderate, 12 (3.6%) severe MD. Having co-wife (aPR: 1.64, CI:1.09–2.45, 0.016), an arranged marriage 1.56, CI: 1.02–2.42, 0.042), partner’s income second quartile 2.14, 1.29–3.54, 0.003), experiencing physical violence 1.75, 1.09–3.81, 0.019), controlling behaviours partner 3.60, 1.79–7.26, 0.001), planned 0.53%, 955 0.35–0.81, 0.003) Conclusion Depression affects nearly one-third more prevalent co-wives, marriages, unplanned pregnancies, partners income, who experienced partner. These findings highlight urgent need targeted interventions, including prevention, screening, treatment services within Antenatal Care clinics. Implementing such measures crucial improving maternal, foetal, health outcomes region.

Language: Английский

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Suicidal ideation in Chinese adolescents: prevalence, risk factors, and partial mediation by family support, a cross-sectional study

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Suicidal ideation is a pressing public health concern, particularly among adolescents. The objective of this study was to examine the prevalence and factors associated with suicidal in Chinese adolescents, addressing an important gap current research.

Language: Английский

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Development and application of a machine learning-based antenatal depression prediction model

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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