Application of Mendelian randomization in thyroid diseases: a review DOI Creative Commons
Zhonghui Li,

Ruohan Wang,

Lili Liu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Thyroid diseases are increasingly prevalent, posing significant challenges to patients' quality of life and placing substantial financial burdens on families society. Despite these impacts, the underlying pathophysiology many thyroid conditions remains poorly understood, complicating efforts in treatment, management, prevention. Observational studies can identify associations between exposure variables disease; however, they often struggle account for confounding factors reverse causation. Understanding disease occurrence, epidemiological trends, clinical diagnosis, prevention, treatment relies heavily robust etiological research. Mendelian randomization, a method grounded genetics epidemiology, has been widely employed studying etiology diseases, offering solution some challenges. This paper categorizes into dysfunction cancer, reviewing related randomization studies. It further provides novel perspectives approaches investigating mechanisms designing intervention strategies.

Language: Английский

The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach DOI Creative Commons
Jianqing Qiu, Ting Zhu,

Ke Qin

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 28, 2025

The current DSM-oriented diagnostic paradigm has introduced the issue of heterogeneity, as it fails to account for identification neurological processes underlying mental illnesses, which affects precision treatment. Research Domain Criteria (RDoC) framework serves a recognized approach addressing this and several assessment translation techniques have been proposed. Among these methods, transforming RDoC scores from electronic medical records (EMR) using Natural Language Processing (NLP) emerged suitable technique, demonstrating clinical effectiveness. Numerous studies sought use understand Diagnostic Statistical Manual Mental Disorders (DSM) categories qualified perspective, but few examined distribution variations interaction characteristics within various DSM through retrospective analyses. Therefore, we employed unsupervised learning translate five domains eRDoC derived patients diagnosed with Major Depressive Disorder (MDD), Schizophrenia (SCZ), Bipolar (BD) at West China Hospital between 2008 2021. characteristics, networks, potential effectiveness were analyzed. Using non-parametric statistical tests, found that MDD had highest score in Negative Valence System (NVS) (4.1, p < 0.001), while BD exhibited Positive (PVS) (4.9, 0.001) Arousal (AS) (4.4, 0.001). SCZ demonstrated Cognitive Systems (CS) (5.8, Social Processes (SPS) (4.6, Through Bayesian network (BN) analysis, identified relatively consistent relationships among (NVS → AS, NVS CS, PVS, well CS SPS; parameter range = 0.156 0.635, Lastly, logistic regression Cox proportional hazards models, AS was significantly associated length hospital stay (-0.21, 0.05) 30-day readmission risk (adjusted odds ratio [aOR] 0.91, 95% confidence interval [CI] 0.91–0.99) some extent. In conclusion, suggest varied different DSM. By Network, might be source interacting other system. Furthermore, SPS 30-days readmission, making them effective predicting prognosis psychiatric disorders.

Language: Английский

Citations

0
Endocrinologia e Imunologia: O caminho para compreender as doenças metabólicas, hormonais e autoimunes - Edição IX DOI Creative Commons
Guilherme Barroso L. De Freitas,

Arthur De Vasconcelos Eigenheer,

Caio Henrique Carneiro da Cunha Guimarães

et al.

Published: June 25, 2024

Quem disse que Imunologia e Endocrinologia não são ciências afins integradas? Cada vez mais as pesquisas demonstram diversas doenças hormonais metabólicas frutos de processos autoimunes (ex: diabetes tipo 1, síndrome Hashimoto, doen

Citations

1
THYROID CANCER AND ITS ASSOCIATION WITH PSYCHIATRIC DISORDERS DOI Creative Commons
Jakub Kuśmierski, Martyna Kuśmierska

Health Problems of Civilization, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

AMA Kuśmierski J, Kuśmierska M. THYROID CANCER AND ITS ASSOCIATION WITH PSYCHIATRIC DISORDERS. Health Problems of Civilization. 2024. doi:10.5114/hpc.2024.139519. APA Kuśmierski, J., & Kuśmierska, (2024). https://doi.org/10.5114/hpc.2024.139519 Chicago Jakub, and Martyna Kuśmierska. "THYROID DISORDERS". Harvard MLA Jakub et al. DISORDERS." Civilization, Vancouver

Language: Английский

Citations

0
Thyroid Nodules and Sleep Disorders DOI

YuRen Zhang,

Qing Ni, Jie Li

et al.

Published: July 15, 2024

Abstract The aim of this study was to explore the association between thyroid nodules and sleep disorders among adult patients diagnosed with nodules. Demographic data were obtained, baseline nodule characteristics evaluated using ultrasonography. Symptoms Scale Pittsburgh Sleep used measure status patients. Overall, 180 participants a mean age 50 ± 12.7 years included in study. majority had TI-RADS grade 3 (80.14%), 4 (18.82%), multiple (70%). Quality Index score (PSQI) revealed that 88.89% PSQI scores > 5, indicating disorders, 10.7 3.6. Analysis based on length grades showed no significant differences. In conclusion, experienced greatly, difficulty falling asleep, poor subjective quality, daytime fatigue, short time having more impact nodules, especially high-risk small Our findings emphasize importance addressing disturbances improve their quality life potentially mitigate diseases.

Language: Английский

Citations

0
Hospital admissions for anxiety disorder, depression, and bipolar disorder and venous thromboembolism: A UK biobank prospective cohort study DOI Creative Commons
Shinya Nakada, Carlos Celis‐Morales, Jill P. Pell

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Few studies have investigated whether and which anxiety affective disorders are associated with the risk of venous thromboembolism. We aimed to examine disorder, depression, bipolar disorder increase thromboembolism, independent socioeconomic confounders each other, in a UK general population.

Language: Английский

Citations

0
Application of Mendelian randomization in thyroid diseases: a review DOI Creative Commons
Zhonghui Li,

Ruohan Wang,

Lili Liu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Thyroid diseases are increasingly prevalent, posing significant challenges to patients' quality of life and placing substantial financial burdens on families society. Despite these impacts, the underlying pathophysiology many thyroid conditions remains poorly understood, complicating efforts in treatment, management, prevention. Observational studies can identify associations between exposure variables disease; however, they often struggle account for confounding factors reverse causation. Understanding disease occurrence, epidemiological trends, clinical diagnosis, prevention, treatment relies heavily robust etiological research. Mendelian randomization, a method grounded genetics epidemiology, has been widely employed studying etiology diseases, offering solution some challenges. This paper categorizes into dysfunction cancer, reviewing related randomization studies. It further provides novel perspectives approaches investigating mechanisms designing intervention strategies.

Language: Английский

Citations

0