Sex differences in the association between metabolic disorder and inflammatory cytokines in Han Chinese patients with chronic schizophrenia

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Previous evidence suggests that immune-inflammatory dysfunction plays an important role in metabolic disorder (MD) of patients with schizophrenia, yet studies on sex differences the association between both are limited. The current study aimed to investigate MD and inflammatory cytokines Han Chinese chronic schizophrenia (CS). This multicentre cross-sectional was conducted one general hospital two psychiatric hospitals Anhui Province, China. General information, parameters cytokine indicators were collected from all participants, severity their symptoms assessed using Positive Negative Syndrome Scale (PANSS). A total 324 completed assessment included this study. had higher age duration illness, lower chlorpromazine equivalents negative symptom score than those without MD. Binary logistic regression showed significantly associated a IL-1β level male patients, while not significant females. Further multiple linear revealed negatively correlated polypharmacy only patients. Sex CS, is there correlation level. Sex-specific prevention intervention strategies may contribute reducing CS.

Language: Английский

Biomarkers of endogenous mental disorders: the role of cortisol, extracellular DNA, BDNF, and cytokines in relation to disease stage and therapy

Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery), Journal Year: 2025, Volume and Issue: 2, P. 245 - 258

Published: Feb. 15, 2025

Background. With the growing number of publications on search for biological markers mental disorders, it is important to analyze studies role extracellular DNA, cortisol, cytokines, and BDNF as severity endogenous depending disease stage antipsychotic treatment. Purpose: available data relationship between biomarkers disorders (cortisol, BDNF) stage, well therapy. Materials method. Publications accessible authors were selected from MEDLINE/PubMed, Scopus, Crossref, eLibrary, RSCI databases using key words “biomarkers disorders”, “stress cortisol”, “cytokines “BDNF”, “extracellular DNA”. A total 428 sources identified, 71 selected, primarily 2020 2024, focusing impact marker levels progression their changes under Priority was given meta-analyses systematic reviews, which reflect recent discoveries can significantly influence future research directions. Conclusion. The review analyzes in patients with associations stress, autoimmune disturbances, (first episode, long-term course, relapse, or remission), therapy, biomarker clinical manifestations illness. Correlations identified specific cognitive impairments, positive symptoms, negative symptoms. Research aims enable early diagnosis, develop new therapeutic targets, stratify optimal protocols, providing opportunities address clinical, diagnostic, therapeutic, rehabilitative challenges.

Language: Английский