Potential Regulation of the Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript1 by Estrogen in Parkinson’s Disease DOI Creative Commons

Eman Adel,

Maya Nicolas

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1662 - 1662

Published: Dec. 16, 2024

Parkinson’s disease (PD) is the second-leading cause of death among neurodegenerative after Alzheimer’s (AD), affecting around 2% population. It expected that incidence PD will exceed 12 million by 2040. Meanwhile, there a recognized difference in phenotypical expression and response to treatment between men women. Men have twice compared women, who late onset worse prognosis usually associated with menopause. In addition, women cumulative estrogen levels their bodies. These differences are suggested be due protective effect on brain, which cannot given clinical practice improve symptoms because its peripheral side effects, causing cancer both males females addition feminizing it has males. As pathophysiology involves alteration multiple LncRNAs, including metastatic-associated lung adenocarcinoma transcript 1 (MALAT1), as been illustrated control MALAT1 conditions, worth investigating estrogen–MALAT1 interaction mimic brain while avoiding effects. The following literature review suggests potential regulation PD, would enhance our understanding disease, improving development more tailored effective treatments.

Language: Английский

Does Parkinson’s disease affect sleep quality? DOI
Hussein A. Hammadi,

Woruod Ahmed Hameed,

Mohammed A. Fakhri

et al.

Irish Journal of Medical Science (1971 -), Journal Year: 2024, Volume and Issue: 193(4), P. 2035 - 2039

Published: April 16, 2024

Language: Английский

Citations

0
The p.Gly2019Ser is the commonest pathogenic mutation in the LRRK2 gene among Egyptians with familial and sporadic Parkinson's disease DOI
Mohamed Salama,

Martina B. William,

Sherifa A. Hamed

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract The impact of LRRK2 variants on the risk Parkinson's disease (PD) in Egyptians remains unknown. We examined 1,210 (611 PD patients and 599 controls) for 12 mutations. p.Gly2019Ser was only variant detected across Egypt, with a prevalence 4.1% sporadic cases, 6.5% familial 0.68% controls. Among carriers, all were heterozygous bar one homozygous patient, shared common haplotype 1. Demographics UPDRS scores did not differ between carriers non-carriers, most being males developed their fifties. Early-onset 33% 25% non-carriers. Familial cases 16% 11% This study affirms that like other North Africans Mediterranean populations, have notably high p.Gly2019Ser. inhibitors could be promising therapeutic options further exploration this population.

Language: Английский

Citations

0
The burden of neurological diseases in conflict settings: Narrative review Gaza situation DOI
Jaber H. Jaradat, Basil Hussam Altah, Seif Jankhout

et al.

Qatar journal of public health., Journal Year: 2024, Volume and Issue: 2024(1)

Published: Sept. 4, 2024

Neurological disorders present formidable challenges, particularly in conflict zones, where access to healthcare is severely restricted. This review examines the profound impact of neurological diseases, including traumatic brain injury (TBI), Alzheimer’s disease, epilepsy, Parkinson’s and post-traumatic stress disorder, on individuals with a focus situation Gaza. Amidst ongoing conflict, Gaza faces significant health crises exacerbated by limited medication, rehabilitation, services due infrastructure destruction resource constraints. Traumatic head injuries, hallmark impose immense strain system, blast-related TBIs are prevalent. underscores critical need for immediate action address crisis Gaza, prioritizing ceasefires, strengthening facilities, providing specialized training professionals, ensuring continued international aid support. Failure act promptly exacerbates suffering increases likelihood permanent disabilities psychological damage, emphasizing urgency situation.

Language: Английский

Citations

0
Emerging roles of the G-protein-coupled receptor 37 in neurological diseases and pain DOI
Xinxin Wang,

Jiajun Ju,

Yafei Xie

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 559, P. 199 - 208

Published: Sept. 6, 2024

Language: Английский

Citations

0
Potential Regulation of the Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript1 by Estrogen in Parkinson’s Disease DOI Creative Commons

Eman Adel,

Maya Nicolas

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1662 - 1662

Published: Dec. 16, 2024

Parkinson’s disease (PD) is the second-leading cause of death among neurodegenerative after Alzheimer’s (AD), affecting around 2% population. It expected that incidence PD will exceed 12 million by 2040. Meanwhile, there a recognized difference in phenotypical expression and response to treatment between men women. Men have twice compared women, who late onset worse prognosis usually associated with menopause. In addition, women cumulative estrogen levels their bodies. These differences are suggested be due protective effect on brain, which cannot given clinical practice improve symptoms because its peripheral side effects, causing cancer both males females addition feminizing it has males. As pathophysiology involves alteration multiple LncRNAs, including metastatic-associated lung adenocarcinoma transcript 1 (MALAT1), as been illustrated control MALAT1 conditions, worth investigating estrogen–MALAT1 interaction mimic brain while avoiding effects. The following literature review suggests potential regulation PD, would enhance our understanding disease, improving development more tailored effective treatments.

Language: Английский

Citations

0