Cancer as an Individual Risk Factor for Heart Failure: A Review of Literature

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 19, 2024

The intricate relationship between cancer and cardiovascular diseases (CVD), notably heart failure (HF), is gaining attention in the medical field. This literature review explores interplay CVD, particularly HF, emphasizing their significant impact on global mortality comorbidity. While preventive measures have contributed to reducing incidence, challenges persist predicting managing cancer-related complications. article delves into various risk factors associated with both including lifestyle factors, genetic predispositions, immune system dysregulation. It highlights emerging evidence suggesting a direct interaction studies indicating an elevated of from patients HF vice versa. Pathological mechanisms such as inflammation, oxidative stress, tissue hypoxia are implicated cancer-induced cardiac dysfunction, underscoring need for comprehensive clinical investigations ethical considerations patient care. also discusses potential role biomarkers assessment, early detection cardiotoxicity, understanding common pathophysiological links paving way multifaceted therapeutic approaches.

Language: Английский

Cardiovascular Mortality in Patients with Gynecological Cancers: A Population-based Cohort Study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

ABSTRACT Objective The survival rate of gynecological cancers (GCs) has improved significantly in recent decades. Patients with GCs did not necessarily succumb to the primary cancer. Cardiovascular health might be a critical determinant long-term survival. This study aimed investigate mortality and risk factors associated cardiovascular disease (CVD) death patients GCs. Methods A total 399,399 cases diagnosed between 2000 2020 from Surveillance, Epidemiology, End Results (SEER) database were included this study. standardized ratio (SMR) for CVD was estimated. Prognostic assessed using cause-specific hazard ratios 95% confidence intervals within competing model, considering non-cardiovascular as risk. Of GCs, 117,551 (29%) died 16,371 (4.1%) CVD. deaths, 73.2% attributed heart disease. SMR highest survivors before age 45 years, remained elevated throughout follow-up period compared general United States (US) population. In SMRs increased steadily all subtypes except vulvar Older age, black race, localized stage, unmarried/single/divorced, vaginal cancers, radiation therapy higher mortality. nomogram developed validated these variables predict Conclusions US constructed forecast individuals More attention should paid during diagnosis improve rates. HIGHLIGHTS ⇒ 29% cancer, while 4.1% CVD, deaths across GC subtypes, Higher linked older unmarried/single/divorced status, prior therapy, especially cancers. We patients, aiding personalized patient management.

Language: Английский

The Complex Connection Between Myocardial Dysfunction and Cancer Beyond Cardiotoxicity: Shared Risk Factors and Common Molecular Pathways

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13185 - 13185

Published: Dec. 8, 2024

Cardiovascular diseases and cancer represent the largest disease burden worldwide. Previously, these two conditions were considered independent, except in terms of cardiotoxicity, which links treatment to subsequent cardiovascular issues. However, recent studies suggest that there are further connections between heart beyond cardiotoxicity. It has been revealed myocardial dysfunction may promote carcinogenesis, indicating additional common pathophysiological mechanisms might be involved relationship cardiology oncology, rather than simply a connection through cardiotoxic effects. These include shared risk factors molecular pathways, such as persistent inflammation neurohormonal activation. This review explores cancer, emphasizing their factors, similar biological mechanisms, causative like along with clinical implications.

Language: Английский