Life's Essential 8 and the risk of cardiovascular disease: a systematic review and meta-analysis

European Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract Aims The benefits of achieving optimal cardiovascular health (CVH) through Life's Simple 7 (LS7) are well-documented across diverse populations. In this study, we assess the updated metrics, Essential 8 (LE8), and its association with long-term disease (CVD) outcomes mortality. Methods results We conducted a comprehensive systematic review, searching PubMed, Google Scholar, Cochrane Library, ScienceDirect from January 2022 until June 2024, focusing on studies that specifically assessed impact LE8 CVH. statistical analysis used RevMan 5.4 applied random effects model to synthesize hazard ratios (HRs) for primary secondary outcomes. This study is registered in PROSPERO (CRD42024558493). Our final comprised 34 observational studies, encompassing 1 786 664 participants aged 18–80 years, an average follow-up approximately 11.6 years. Pooled revealed statistically significant decrease risk CVD among individuals higher scores compared those lower scores, HR 0.47 (95% CI: 0.39–0.56, P < 0.00001). Higher were also associated reductions both all-cause mortality (HR: 0.54, 95% 0.43–0.69, 0.00001) CVD-related 0.37, 0.26–0.52, 0.00001. Moreover, high have 56% coronary heart 48% stroke. Conclusion has strong inverse mortality, corresponding significantly levels.

Language: Английский

Association between life’s crucial 9 and severe abdominal aortic calcification in U.S. Adults: the mediating role of the systemic inflammatory response index

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Life’s Crucial 9 (LC9) is an emerging cardiovascular health scoring system that incorporates Essential 8 (LE8) alongside mental factors. However, its relationship with severe abdominal aortic calcification (SAAC) remains poorly understood. Objectives The objective of this study to investigate the between LC9 scores and incidence SAAC in US population. Methods Data from 2,323 participants were analyzed, originating 2013-2014 National Health Nutrition Examination Survey (NHANES) cycle. In exploring dynamics LC9, constituents, their SAAC, we employed advanced statistical methodologies, specifically multivariable logistic regression weighted quantile sum regression. Subgroup interaction analyses conducted reinforce conclusions, mediation analysis was how systemic inflammatory response index (SIRI) influences connection SAAC. Results fully adjusted models, increase 10 points associated a 26% reduction prevalence achieving significance ( P < 0.001). As increased, significant decline noted 0.05). WQS pinpointed strong links occurrence variables including exposure tobacco, blood pressure levels, glucose concentrations, status, odds ratio stood at 0.244, 95% CI extending 0.119 0.495. SIRI positively correlated 0.05) decreased rising (β = -0.09, Mediation revealed significantly influenced linkage accounting for 5.8% effect, statistically p-value Conclusion This research highlights robust inverse elevated reduced incidence, suggesting role as key factor diminishing frequency Furthermore, mediates relationship.

Language: Английский

Evaluating the Incremental Value of an Expanded Cardiovascular Health Score for the Prevalence of Abdominal Aortic Calcification Among Middle-aged and Elderly Individuals

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: unknown, P. 200389 - 200389

Published: March 1, 2025

Language: Английский