Published: Jan. 1, 2024
Language: Английский
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 29, 2025
Background Asthma poses a significant public health burden in China, affecting millions with substantial incidence and mortality. Understanding the trends future projections of asthma mortality is crucial for healthcare planning. Methods We analyzed data sourced from Global Burden Disease (GBD) 2021 study 1990 to 2021, calculated age-standardized rates (ASIR ASMR) estimated annual percentage change (EAPC), meanwhile, employed Joinpoint regression model assess trends. The age-period-cohort was applied estimate effects age, period, cohort on Finally, next 25 years were predicted utilizing Bayesian (BAPC) model. Results Over past three decades, rate declined waves while steadily. ASIR decreased 524.81 364.17 ASMR 5.82 1.47. are consistently higher males than females during this period. effect attributable age younger group older. period ratio calendar year, corrections between birth risk negative. Our indicate that will continue decrease by 2046, expected 330 0.69, respectively. Instead, absolute number cases deaths may increase approximately 4.5 million 80,000, Conclusion Although have generally remains significant, especially among vulnerable groups, males. Continuous monitoring age-targeted interventions essential. Future strategies must address aging population manage projected deaths.
Language: Английский
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Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 15, 2025
Fine particulate matter 2.5 (PM2.5) is a prevalent atmospheric pollutant that closely associated with asthma. Elderly patients have high incidence of asthma long course illness. Our previous studies revealed exposure to PM2.5 diminishes lung function and exacerbates damage in elderly rats. In the present study, we investigated whether influences susceptibility allergic Brown-Norway rats were treated ovalbumin (OVA) for different durations before after exposure. The results from pulmonary tests histopathology indicated early allergens prior increased airway hyperresponsiveness led severe injury asthmatic Cytokine microarray analysis demonstrated majority cytokines chemokines upregulated OVA-treated Cytological examination showed no change eosinophil (EOS) counts, yet amounts neutrophils (NEU), white blood cells (WBC), lymphocytes (LYM), monocytes (MON) lavage fluid significantly higher than those control exposure, suggesting affects noneosinophilic ELISA plasma levels IgG1, IgE, IgG2a IgG2b elevated rats, whereas level was lower OVA compared afterward. A non-targeted metabolomic identified 202 metabolites, among which 31 metabolites differentially abundant. Ten 11 metabolic pathways uniquely detected Specifically, there positive or negative correlations between Th2-associated (IL-4, IL-5, IL-13) six group IL-4 IL-5 negatively correlated five findings suggest could influence response potentially through changes metabolites.
Language: Английский
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Journal of Asthma, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8
Published: March 7, 2025
To investigate risk factors associated with severe acute asthma attacks in children over six years of age. This retrospective study enrolled aged diagnosed exacerbation at the Department Pulmonology, Quanzhou Children's Hospital, from January 2012 to September 2024. Data on patients' clinical manifestations were compared between mild moderate and attack groups. The average age 261 patients was 8.03 ± 1.88 years. categorized into two groups based severity: (n = 209) 52). Univariate analysis revealed significant differences terms malnutrition, breastfeeding duration (over three months), eosinophil neutrophil percentages, human rhinovirus (HRV) infection, mediastinal emphysema, subcutaneous emphysema (p < 0.05). Logistic regression that hospitalized for more likely experience exacerbations if they had an elevated % (OR 1.040), HRV infection 5.655), malnutrition 5.051), or 9.205). ROC a percentage threshold 69.35 (the value count 6 old is 1.6-8.3 × 109/L) diagnostically useful asthma, sensitivity 0.750, specificity 0.617, area under curve 0.73. level neutrophils, history are all independent Management strategies should be expanded focus high-risk order avoid attacks.
Language: Английский
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0
Published: Jan. 1, 2024
Language: Английский
Citations
0